Comparison of iohexol-240 versus iohexol-300 in abdominal CT

Singer, Anne A.; Tagliabue, James R.; Paushter, David M.; Borkowski, Gregory P.; Einstein, David M.

doi:10.1007/bf01888525

Cited by 11 publications

(3 citation statements)

References 13 publications

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“…Therefore, results from studies with other solid organs cannot be directly applied to the kidney. In addition, most previous reports did not perform studies in the same patient (3-7, 9), and only a few reports have described CT imaging in the same patient (10-12). Considering radiation and contrast media exposure, an intra-individual comparison study has many limitations.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Use of Contrast Media with Different Iodine Concentrations for Multidetector CT of the Kidney

2011

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ObjectiveTo determine the optimal iodine concentration of contrast media for kidney multidetector computed tomography (MDCT) by comparing the degree of renal parenchymal enhancement and the severity of the renal streak artifact with contrast media of different iodine concentrations.Materials and MethodsA 16-row MDCT was performed in 15 sedated rabbits by injection of 2 mL contrast media/kg body weight at a rate of 0.3 mL/sec. Monomeric nonionic contrast media of 250, 300, and 370 mg iodine/mL were injected at 1-week intervals. Mean attenuation values were measured in each renal structure with attenuation differences among the structures. The artifact was evaluated by CT window width/level and three grading methods. The values were compared with iodine concentrations.ResultsThe 370 mg iodine/mL concentration showed significantly higher cortical enhancement than 250 mg iodine/mL in all phases (p < 0.05). There was however no significant difference in the degree of enhancement between the 300 mg iodine/mL and 370 mg iodine/mL concentrations in all phases. There is a significant difference in attenuation for the cortex-outer medulla between 250 mg iodine/mL and 300 mg iodine/mL (p < 0.05). The artifact was more severe with a medium of 370 mg iodine/mL than with 250 mg iodine/mL by all grading methods (p < 0.05).ConclusionThe 300 mg iodine/mL is considered to be the most appropriate iodine concentration in an aspect of the enhancement and artifact on a kidney MDCT scan.

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Section: Introductionmentioning

confidence: 99%

A Comparison of the Use of Contrast Media with Different Iodine Concentrations for Multidetector CT of the Kidney

2011

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“…Regarding the detectability of lesions in the liver (which is dependent on the contrast enhancement within the parenchyma) controversial results have been published with different contrast media. Some studies have shown that there is no difference between non-ionic media compared with ionic media (7,12,14,15,17,18). DEAN et al (7) showed that there were different concentrations of iodine in the tissues of the spleen and liver following metrizamide, iopamidol and iohexol injections.…”

Section: Discussionmentioning

confidence: 99%

Contrast Enhancement of the Upper Abdomen Evaluated BY CT

1995

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The non-ionic monomeric contrast media iopamidol and iohexol were compared concerning enhancement in the organs of the upper abdomen in CT. The average peak enhancement above the base line for the 2 contrast media in the liver, vena cava, aorta and spleen was calculated. No difference between the contrast media was found with regard to increase in contrast enhancement. No correlation between the peak enhancement and body weight and body surface was found with either of the 2 contrast media.

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“…Iopentol300 solution (320 mgI/ml vs 300 mgI/ml), with results comparable to the less concentrated iohexol 300 and iopentol 300. Different authors (15, 16) have suggested that the use of a reduced amount of contrast media (i.e., 32 gI vs 45 gI) or use of contrast media with a lower iodine concentration (i.e., 240 mgI/ml vs 300 mgI/ml) is preferable due to cost savings and lower iodine load, without impairing the diagnostic quality of the examination (15, 16). Figure 3 shows the liver AUC values corrected for the amount of iodine administered and the cost per gram of iodine for all four contrast agents.…”

Section: Ct Examinations Were Performed On a Philipsmentioning

confidence: 99%

Assessing the effectiveness of X–ray contrast media for abdominal computed tomographic examinations: comparison of four low–osmolality agents

et al. 1995

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The objective of this investigation was to assess the effectiveness of four iodinated X-ray contrast media for abdominal computed tomographic (CT) examinations. Fifty-three patients were prospectively randomized to receive iohexol 300 mgI/ml (100 ml, n = 17), ioversol 320 mgI/ml (100 ml, n = 13), iopromide 300 mgI/ml (75 ml, n = 12), or iopentol 300 mgI/ml (100 ml, n = 11) to perform a dynamic contrast-enhanced abdominal CT. Image-enhancement profiles for the liver, aorta, and vena cava were studied. The maximum liver enhancement, the time to maximum liver enhancement, and the area under the hepatic enhancement-time curve (AUC) were determined for each examination. Liver-enhancement profile showed significant differences between the four contrast agents, with lower values for iopromide towards the final part of the CT examination (P < 0.05). Hepatic peak values were attained earlier for iopromide, although these were lower than those produced by any other of the agents evaluated in this study. Iopentol produced fast and intense hepatic peaks. Consequently, high AUC values were obtained with iopentol, low values were obtained with iopromide (P < 0.05), although this can be explained by the lower amount of contrast medium contained in the commercial vial and administered to the patient (75 ml vs 100 ml). When normalized to a 100 ml dose, the AUC value for iopromide becomes even higher than the average of the other three agents (P = 0.05). Ioversol, although available and administered as a more concentrated solution (320 mg/ml), was comparable to the less concentrated iohexol and iopentol (300 mgI/ml).(ABSTRACT TRUNCATED AT 250 WORDS)

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Comparison of iohexol-240 versus iohexol-300 in abdominal CT

Cited by 11 publications

References 13 publications

A Comparison of the Use of Contrast Media with Different Iodine Concentrations for Multidetector CT of the Kidney

A Comparison of the Use of Contrast Media with Different Iodine Concentrations for Multidetector CT of the Kidney

Contrast Enhancement of the Upper Abdomen Evaluated BY CT

Assessing the effectiveness of X–ray contrast media for abdominal computed tomographic examinations: comparison of four low–osmolality agents

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