Comparison of Intravenous Nitroglycerin and Sodium Nitroprusside for Treatment of Acute Hypertension Developing after Coronary Artery Bypass Surgery

Flaherty, John T.; Magee, Patrick; Gardner, Timothy; Potter, A.; MacAllister, N. P.

doi:10.1097/00132586-198304000-00044

Cited by 5 publications

(6 citation statements)

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“…Многие сосудорасширяющие препараты, в том числе нитропруссид натрия и нитроглицерин, подавляют гипоксическую легочную вазоконстрикцию, увеличивая фракцию шунтирования крови в легких и, тем самым, ухудшая артериальную оксигенацию [20][21]. После введения урапидила существенного увеличения шунтирования или снижения напряжения кислорода в артериальной крови не наблюдалось, так как урапидил не подавляет гипоксическую легочную вазоконстрикцию [18].…”

Section: применение урапидила при гипертонических кризахunclassified

“…При недостаточном терапевтическом эффекте возможно повторное введение препарата до максимально допустимой дозы 100 мг. Пациентам, у которых антигипертензивный эффект урапидила оказывается недостаточно стойким, целесообразно проводить капельную инфузию препарата со скоростью введения от 5 до 40 мг/ч, в среднем 15 мг/ч [21][22][23].…”

Section: применение урапидила у пациентов с гипертоническими кризамиunclassified

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Use of Urapidil - Antihypertensive Drug With Double Action - New Direction in Treatment of Hypertensive Crises

Абдрахманов

Гапонова

Плавунов

2014

Racionalʹnaâ farmakoterapiâ v kardiologii

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Обсуждаются результаты клинических исследований, посвященных антигипертензивному действию препарата урапидил, обладающего центральным и периферическим действием. Выделены группы пациентов, которым показано применение урапидила. Подробно изложен режим дозирования и способы применения урапидила при различных клинических ситуациях, сопровождающихся острым повышением артериального давления. Ключевые слова: артериальная гипертензия, гипертонический криз, антигипертензивная терапия, урапидил. Рациональная фармакотерапия в кардиологии 2014;10(5):559-564 Use of urapidil-antihypertensive drug with double action-new direction in treatment of hypertensive crises

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Section: применение урапидила при гипертонических кризахunclassified

Section: применение урапидила у пациентов с гипертоническими кризамиunclassified

Use of Urapidil - Antihypertensive Drug With Double Action - New Direction in Treatment of Hypertensive Crises

Абдрахманов

Гапонова

Плавунов

2014

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…Previous studies have shown that ketanserin tends to reduce or have minimal effect on heart rate, whereas SNP tends to produce tachycardia [5,13,14]. Mean heart rate for each patient was analysed for 10 min before ketanserin was administered, and for the 10 min after the bolus dose was given.…”

Section: Ketanserin and Heart Ratementioning

confidence: 99%

Effect of Ketanserin on Sodium Nitroprusside Requirements, Arterial Pressure Control and Heart Rate Following Coronary Artery Bypass Surgery

Hodsman

Colvin

1989

British Journal of Anaesthesia

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In a double-blind, placebo controlled study ketanserin, a serotonin S2 antagonist, was administered to hypertensive patients who had undergone coronary artery bypass surgery. Patients were allocated randomly to receive placebo or ketanserin at an infusion rate of 0.05, 1 or 2 mg kg-1 h-1. Sodium nitroprusside was used as escape medication. Ketanserin reduced the nitroprusside requirements and improved the quality of arterial pressure control in all groups, and this was significant in the low- and high-dose groups. There was a significant decrease in heart rate in the low- and high-dose groups compared with placebo, and no effect in patients who received the medium dose of ketanserin. Ketanserin may be a useful treatment for hypertension following coronary artery surgery as it reduced arterial pressure without reflex tachycardia.

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“…hypertension and concomitant coronary artery disease [38]. Nitroglycerin predominantly dilates the venous capacitance vessels, but higher infusion rates cause arterial dilatation.…”

Section: Hypertensive Crisis Arising From Systemicmentioning

confidence: 99%

Hypertensive Crises

Ram

Hyman

1987

J Intensive Care Med

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Hypertensive crises are a group of medical conditions in which a rapid decrease in blood pressure is necessary to prevent serious complications. Although uncommon in clinical practice, a hypertensive crisis should be recognized and treated promptly. Any form of hypertension may be associated with hypertensive crisis, the main determinant being the level of blood pressure rather than the cause of hypertension. In certain clinical situations the abruptness with which the blood pressure increases seems to be more important than the absolute level of blood pressure in causing the hypertensive crisis (e.g., toxemia of pregnancy in women and acute onset of hypertension in children with acute glomerulonephritis). In other clinical situations the absolute level of blood pressure does not affect the seriousness of hypertension so much as coexisting complications that may make even moderate hypertension dangerous (e.g., acute aortic dissection and acute left ventricular failure ).

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Comparison of Intravenous Nitroglycerin and Sodium Nitroprusside for Treatment of Acute Hypertension Developing after Coronary Artery Bypass Surgery

Cited by 5 publications

References 0 publications

Use of Urapidil - Antihypertensive Drug With Double Action - New Direction in Treatment of Hypertensive Crises

Use of Urapidil - Antihypertensive Drug With Double Action - New Direction in Treatment of Hypertensive Crises

Effect of Ketanserin on Sodium Nitroprusside Requirements, Arterial Pressure Control and Heart Rate Following Coronary Artery Bypass Surgery

Hypertensive Crises

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