Comparison of intravenous ibuprofen and paracetamol in the treatment of fever: A randomized double-blind study

Can, Özge; Kiyan, Güçlü Selahattin; Yalçınlı, Sercan

doi:10.1016/j.ajem.2021.02.057

Cited by 3 publications

(11 citation statements)

References 18 publications

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“…The assessment of the risk of bias was summarized in Figure 2, Figure 3, and Supplementary Table 3. 56.3% of trials (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) had an unclear risk of bias owing to insufficient information about random sequences, allocation concealment, and the blinding of participants, personnel, and outcome assessors. 28.1% of trials (40)(41)(42)(43)(44)(45)(46)(47)(48) showed a low risk of bias and 15.6% of trials (49-53) had a high risk of blinding of participants and personnel, selective reporting, or other bias.…”

Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

“…Five RCTs (22,24,36,40,41) discussed the antipyretic efficacy of IVIB in adult patients with severe (malaria and burns) or non-severe illnesses (tonsillopharyngitis and emergency fever). Three of the studies (22,24,40) compared the efficacy and safety of IVIB with placebo, and we conducted descriptive analysis only.…”

Section: Antipyretic Managementmentioning

confidence: 99%

Section: Antipyretic Managementmentioning

confidence: 99%

“…Two studies (36,41) compared the antipyretic effect of a single dose of IVIB (400 mg) with that of acetaminophen (1000 mg), both of which showed a better antipyretic effect and a significant reduction in temperature from baseline (Can et al, P = 0.001; Oncel et al, P < 0.001). However, Can et al (36) found that there was no difference in the antipyretic effect between IVIB and intravenous acetaminophen 30 minutes after administration (P = 0.980). Additionally, Oncel et al (41) found that IVIB was more effective in reducing temperature than intravenous acetaminophen at 15 minutes after administration (median: 0.60 vs 0.40, P = 0.036), whereas there was no difference in the changes of the fever at 60 minutes (median: 1.5 vs 1.5, P = 0.350).…”

Section: Antipyretic Managementmentioning

confidence: 99%

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Intravenous Ibuprofen in Postoperative Pain and Fever Management in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Zhou¹,

Chen²,

Wang

et al. 2023

Preprint

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Aims: Intravenous ibuprofen (IVIB) has been approved in the treatment of postoperative pain and fever in adults, but the application of multiple- or single- dosage IVIB remains divergent in clinical practice. This study aims to evaluate the efficacy and safety of IVIB in the management of postoperative pain and fever in adults who were unable to take oral medicine. Methods: A systematic review and meta-analysis was conducted based on randomized controlled trials (RCTs) regarding postoperative pain and fever management comparing IVIB with placebo, or other analgesic and antipyretic agents from 8 databases. Risk of bias and quality of evidence assessment were performed. The primary outcomes mainly included visual analogue scale (VAS) score within postoperative 24h and the reduction of temperature. Results: Twenty-three RCTs with 3716 participants were included. For postoperative pain, moderate-to-low certainty evidence indicated that IVIB was associated with lower postoperative VAS scores than placebo, with MD ranging between -3.53 (95% CI, -4.32 to -2.75) at 0 minute to -0.96 (95% CI, -1.35 to -0.57) at 24 hours. Compared to intravenous acetaminophen, IVIB appeared lower VAS scores (MD, -1.54 at 0min; -0.36 at 24h). For fever, IVIB appeared satisfactory antipyretic efficiency in a short period of time, but there was no difference between IVIB and intravenous acetaminophen. Moderate-to-low certainty evidence indicated that IVIB was well tolerated in both pain and fever management. Conclusions: Moderate-to-low certainty evidence supported that adults with postoperative pain and fever who were unable to take oral medicine would benefit from IVIB.

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Section: Quality Assessment Of Included Studiesmentioning

confidence: 99%

Section: Antipyretic Managementmentioning

confidence: 99%

Section: Antipyretic Managementmentioning

confidence: 99%

Section: Antipyretic Managementmentioning

confidence: 99%

See 2 more Smart Citations

Intravenous Ibuprofen in Postoperative Pain and Fever Management in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Zhou¹,

Chen²,

Wang

et al. 2023

Preprint

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“…Two studies 52,53 compared the antipyretic effect of a single dose of IVIB (400 mg) with IA (1000 mg). Both studies showed a F I G U R E 6 Forest plot for the incidence of AEs (IVIB vs. placebo).…”

Section: Antipyretic Managementmentioning

confidence: 99%

Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials

Zhou,

Chen,

Wang

et al. 2023

Pharmacology Res & Perspec

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This study aims to evaluate the efficacy and safety of multiple or single‐dosage intravenous ibuprofen (IVIB) in managing postoperative pain and fever in adults who are unable to take oral medications. A systematic review and meta‐analysis was conducted based on randomized controlled trials (RCTs) comparing IVIB with placebo or other analgesic and antipyretic medications for postoperative pain and fever management. Data were collected from 8 main databases from the inception to June 2022. Risk of bias assessment was performed, and the GRADE methodology was used to assess the certainty of pooled evidence. Primary outcomes included visual analogue scale (VAS) scores within 24 h postoperative and reduction of temperature. Meta‐analyses were conducted to calculate the mean difference (MD) or risk ratios (RR) and 95% CIs. As a result, a total of twenty‐three RCTs with 3716 participants were included. For postoperative pain, with moderate‐to‐low certainty evidence, IVIB was associated with lower postoperative VAS scores than placebo, with MD ranging from −3.53 (95% CI, −4.32 to −2.75) at 0 min to −0.96 (95% CI, −1.35 to −0.57) at 24 h. Compared with intravenous acetaminophen, IVIB demonstrated lower VAS scores (MD, −1.54 at 0 min; −0.36 at 24 h). For fever, IVIB showed satisfactory antipyretic efficiency in a short period of time, but no difference was observed between IVIB and intravenous acetaminophen. IVIB was well‐tolerated for both pain and fever management. In conclusion, moderate‐to‐low certainty evidence supports the use of IVIB for adults with postoperative pain and fever who are unable to take oral medications.

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Kombinasi Analgesik Non-opioid Intravena untuk Tata Laksana Nyeri Akut

Lukito

2023

Cermin Dunia Kedokteran

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Konsep analgesia multimodal dianjurkan untuk pengobatan nyeri. Paracetamol dan nonsteroidal antiinflammatory drugs (NSAID) umumnya menjadi analgesik dasar, serta dikombinasikan dengan opioid sesuai kebutuhan. Analgesik intravena (IV) dapat menjadi solusi bagi pasien yang tidak dapat menerima analgesik per oral. Kombinasi paracetamol dan ibuprofen IV menunjukkan efek analgesik yang signifikan, dengan manfaat opioid sparing, antipiretik, serta dengan profil keamanan yang relatif baik pada pasien nyeri akut. The concept of multimodal analgesia is recommended for the treatment of pain. Paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) are generally the basic analgesics, and are combined with opioids as needed. Intravenous (IV) analgesics may serve as an alternative for patients who cannot tolerate oral analgesics. The IV combination of paracetamol and ibuprofen for acute pain shows a significant analgesic effect with the benefits of opioid sparing, also with antipyretic effect, and with a relatively good safety profile.

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Comparison of intravenous ibuprofen and paracetamol in the treatment of fever: A randomized double-blind study

Cited by 3 publications

References 18 publications

Intravenous Ibuprofen in Postoperative Pain and Fever Management in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Intravenous Ibuprofen in Postoperative Pain and Fever Management in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta‐analysis of randomized controlled trials

Kombinasi Analgesik Non-opioid Intravena untuk Tata Laksana Nyeri Akut

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