Comparison of intravenous famotidine and ranitidine in suppressing gastric acid secretion in critically ill patients

Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection

“…Al‐Quorain et al . investigated the pH of gastric juice during continuous intravenous administration of H2RA to critically ill patients and found that, whereas ranitidine‐treated patients exhibited marked tolerance, no such phenomenon occurred during famotidine treatment 18 . Conversely, Nwokolo et al .…”

“…Famotidine is a more recently developed H2RA that is reported to have stronger acid‐suppressing activity than ranitidine 14–17 . There have been conflicting results concerning the development of tolerance to famotidine treatment 18 . Therefore, in the present study, we investigated changes in 24‐h pH‐monitoring values, together with serum gastrin and drug concentrations, during administration of famotidine for 14 days, and compared these parameters with those obtained with ranitidine.…”