Comparison of Intratympanic Steroid Injection, Hyperbaric Oxygen and Combination Therapy in Refractory Sudden Sensorineural Hearing Loss

Yang, Chao‐Hui; Wu, Re‐Wen; Hwang, Chung‐Feng

doi:10.1097/mao.0b013e3182a1eb83

Cited by 37 publications

(44 citation statements)

References 32 publications

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“…Our study showed that HBO therapy as salvage therapy significantly improves the outcome in patients with a hearing loss of >61 dB, while some previous studies have found the benefit of HBO therapy only among patients presenting with profound hearing loss (>80 or >90 dB) [19,21,22] . In the group of patients with a hearing loss of ≤60 dB, improvement was noticed only at low frequencies (0.25 and 0.5 kHz), which is consistent with a previous study on SSNHL that showed that the apical part of the cochlea recover better than the basal parts [24] . Spontaneous recovery of hearing has been described in the first few weeks form the onset of SSNHL, but hearing recovery after the failure of primary therapy is very low.…”

Section: Discussionsupporting

confidence: 78%

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Ajduk¹,

Ries²,

Trotić³

et al. 2017

Int Adv Otol

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OBJECTIVE:To measure the effect of hyperbaric oxygen (HBO) therapy as salvage therapy after the failure of steroid therapy for sudden sensorineural hearing loss (SSNHL). MATERIALS and METHODS:Ninety-three patients with SSNHL were unsuccessfully treated with systemic steroid therapy. Following steroid therapy, 43 patients received additional HBO therapy while 50 did not. Hearing levels at 0.25, 0.5, 1, 2, 4, and 8 kHz before and after therapy were measured. RESULTS:A significant difference in hearing thresholds after HBO therapy was found at all frequencies in patients with a hearing loss of >61 dB. The group of patients with a hearing threshold of ≤60 dB had a significant improvement only at 250 and 500 Hz, while group of patients without additional therapy control group showed no hearing improvement. CONCLUSION:Hyperbaric oxygen therapy therapy as salvage therapy for SSNHL showed some benefits in hearing improvement. Better results could be expected in patients with severe hearing loss, while in patients with mild-or-moderate hearing loss, recovery should be expected only at low frequencies.

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Section: Discussionsupporting

confidence: 78%

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Ajduk¹,

Ries²,

Trotić³

et al. 2017

Int Adv Otol

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“…Steroids, vasodilators, plasma expanders, and antiviral and diuretic agents are preferred for these purposes in different combinations [10] . Low-molecular-weight heparin (LMWH) and hyperbaric oxygen (HBO) therapies have also been reported to have some treatment advantages [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Recovery of Idiopathic Sudden Sensorineural Hearing Loss

Edızer¹,

Çelebi²,

Hamit³

et al. 2015

Int Adv Otol

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OBJECTIVE:The objective was to identify and evaluate factors that may influence the recovery rate in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). MATERIALS and METHODS:A retrospective analysis was performed for patients with sudden sensorineural hearing loss between 2009 and 2013. Those with an identified etiology were excluded. The patients were divided into four treatment groups: (i) systemic corticosteroids (SC) only, (ii) SC+low-molecular-weight heparin (LMWH), (iii) SC+hyperbaric oxygen (HBO), and (iv) SC+LMWH+HBO. Recovery was evaluated according to Siegel's criteria. Age, initial hearing level, onset, treatment and audiogram types, comorbidities, and associated tinnitus and vestibular symptoms were investigated for their impact on prognosis. RESULTS:Two hundred five patients with ISSNHL were included. Recovery was seen in 59% of the patients. The complete recovery rate was significantly lower in patients older than 60 years and in patients presenting with profound hearing loss. Different audiogram curves had no significant effect on recovery. Sudden hearing loss was accompanied by tinnitus in 107 (52.1%) patients and vestibular symptoms in 55 (26.8%); however, neither was noted to affect prognosis. Different treatment combinations did not significantly affect prognosis. However, hypertension and a delay in treatment by more than 10 days from the onset of hearing loss were associated with a worse prognosis. CONCLUSION:Profound hearing loss, older than 60 years, a delay in treatment by more than 10 days, and hypertension were negative prognostic factors in this study, whereas, the type of audiogram curve and addition of HBO to SC did not affect prognosis.

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“…Furthermore, to the best of our knowledge, there is very limited data regarding the efficacy of HBO therapy following combined steroid (systemic+ITS) treatment. [10] In our study, we found that the addition of HBO therapy after failure of combined steroid treatment led to statistically significant hearing improvement in patients with severe (≥70 dB) hearing loss. HBO therapy showed significant improvement in mean hearing thresholds at all frequencies.…”

Section: Discussionmentioning

confidence: 71%

“…[12] Although prospective clinical trials of salvage HBO therapy with a control group are limited, result of these studies showed some benefits in hearing improvement. [10,13,14] The results of salvage HBO therapy in previous studies are demonstrated in Table 4. [9,[14][15][16][17][18] To date, no reports have been published about the hearing outcomes of salvage HBO therapy after combined steroid treatment.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic efficacy of salvage hyperbaric oxygen therapy in sudden sensorineural hearing loss after failure of steroids

İmre¹,

Aladağ²,

Pınar³

et al. 2017

ENT Updates

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Comparison of Intratympanic Steroid Injection, Hyperbaric Oxygen and Combination Therapy in Refractory Sudden Sensorineural Hearing Loss

Abstract: ITS, HBO, and combined therapy offered some benefits in hearing improvement. Combined ITS/HBO may result in a larger WRS improvement and recovery of hearing, especially in lower frequencies. Further randomized prospective studies are needed for confirmation.

Cited by 37 publications

References 32 publications

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Hyperbaric Oxygen Therapy as Salvage Therapy for Sudden Sensorineural Hearing Loss

Recovery of Idiopathic Sudden Sensorineural Hearing Loss

Therapeutic efficacy of salvage hyperbaric oxygen therapy in sudden sensorineural hearing loss after failure of steroids

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