Comparison of intraperitoneal ropivacaine and bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy

Lambertini, Carlotta; Kluge, Katharina; Lanza-Perea, Marta; Bruhl-Day, R.; Guerrero, Karin S Kalchofner

doi:10.1016/j.vaa.2018.06.012

Cited by 25 publications

(45 citation statements)

References 12 publications

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“…However, as previously observed with incisional anaesthesia (Fitzpatrick et al 2010), the results were likely confounded by the concurrent use of other analgesics such as morphine and carprofen (Kalchofner Guerrero et al 2016). In a follow-up study, the IP administration of ropivacaine 0.75% (3 mg/kg) or bupivacaine 0.5% (3 mg/kg) without incisional anaesthesia provided similar postoperative analgesia when administered in combination with morphine and carprofen (Lambertini et al 2018) but 15 out 44 dogs required the administration of rescue analgesia. So-called incisional "splash block" techniques have, as described above, been incorporated into several studies.…”

Section: Canine Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

Steagall

Benito

Monteiro

et al. 2019

J of Small Animal Practice

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The World Small Animal Veterinary Association Global Pain Council (WSAVA‐GPC) has recently published its first “capsule review” by Monteiro et al. These are short articles that present a brief assessment of the scientific evidence and practical recommendations on important, and sometimes controversial, subjects in pain management. The capsules will be published regularly in the Journal of Small Animal Practice, the official journal of the WSAVA. This second article discusses the use of intraperitoneal and incisional analgesia in small animal practice, including their limitations and recommendations by the authors.

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Section: Canine Studiesmentioning

confidence: 99%

“…In a follow‐up study, the IP administration of ropivacaine 0.75% (3 mg/kg) or bupivacaine 0.5% (3 mg/kg) without incisional anaesthesia provided similar postoperative analgesia when administered in combination with morphine and carprofen (Lambertini et al . ) but 15 out 44 dogs required the administration of rescue analgesia.…”

Section: Canine Studiesmentioning

confidence: 99%

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

Steagall

Benito

Monteiro

et al. 2019

J of Small Animal Practice

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“…▪ Epidural catheters can be placed in larger dogs and maintained for several days to allow continuous or intermittent delivery of analgesic drugs (Swalander, Crowe, Hittenmiller, & Jahn, 2000). Barnes, & Hauptman, 2004;Benito et al 2016;Lambertini, Kluge, Lanza-Perea, Bruhl-Day, & Kalchofner Guerrero, 2018;Figure 8 and Box 17 and 18) or direct infiltration of the mesovarium ligament (Box 16). For both techniques, the skin and subcutaneous tissues at the incision site should also be blocked.…”

Section: Box 18 (Continued)mentioning

confidence: 99%

Local and regional anaesthesia in dogs and cats: Descriptions of specific local and regional techniques (Part 2)

Grubb

Lobprise

2020

Veterinary Medicine & Sci

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Pain management in veterinary patients is a crucial component of appropriate patient care. Local anaesthetic drugs used in local and regional blockade can completely block the transmission of nociceptive impulses, decreasing both intra-operative nociception and postoperative pain, while decreasing the potential incidence of adverse effects that can be associated with systemic boluses of drugs. For efficacy and safety, this class of drugs is recommended as part of the analgesic protocol in the majority of surgical procedures and traumatic injuries. Numerous local and regional blocks are proven effective in dogs and cats, thus providing the clinician with ample opportunity to include these blocks in practice. This manuscript, Part 2 of a two-part instalment, focuses on brief descriptions of select commonly used local/regional anaesthesia techniques for dogs and cats that cover a multitude of painful surgeries/injuries and that can be implemented in any practice. In Part 1 of this topic, detailed information on local anaesthetic drugs commonly used in small animal practice was reviewed . K E Y W O R D Sanalgesia, bupivacaine, liposome-encapsulated, local anaesthetics, local block This article is linked to "Local and regio nal anaes thesi a in dogs and cats: Overv iew of conce pts and drugs (Part 1)."

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“…In a prospective, randomized, blinded, positive-controlled clinical study, cats were randomly assigned using an online software program 11 to receive one of the three treatments (n = 15): S group, local infiltration of physiological saline (0.4 mL/kg); R group, local infiltration of ropivacaine 12 (1 mg/kg); RM group, local infiltration of ropivacaine (1 mg/kg) combined with meloxicam 13 (0.2 mg/kg). Meloxicam (0.2 mg/kg) was administered subcutaneously to cats of the S and R groups after orotracheal intubation.…”

Section: Study Design and Treatment Administrationmentioning

confidence: 99%

“…The lower toxicity of ropivacaine represents an advantage, especially for cats, because this species appears more susceptible than dogs to the toxic effects of local anesthetics [10]. In isoflurane-anesthetized dogs undergoing ovariohysterectomy, the analgesic effects of intraperitoneal instillation of ropivacaine were considered similar to those provided by an equivalent dose of bupivacaine [11]. Intratesticular and incisional ropivacaine decreased intraoperative isoflurane requirements in dogs undergoing orchiectomy [12].…”

Section: Introductionmentioning

confidence: 99%

Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy

et al. 2020

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Background: Infiltration of the surgical site with local anesthetics combined with nonsteroidal anti-inflammatory drugs may play an important role in improving perioperative pain control. This prospective, randomized, blinded, controlled clinical trial aimed to evaluate intraoperative isoflurane requirements, postoperative analgesia, and adverse events of infiltration of the surgical site with ropivacaine alone and combined with meloxicam in cats undergoing ovariohysterectomy. Forty-five cats premedicated with acepromazine/meperidine and anesthetized with propofol/isoflurane were randomly distributed into three treatments (n = 15 per group): physiological saline (group S), ropivacaine alone (1 mg/kg, group R) or combined with meloxicam (0.2 mg/kg, group RM) infiltrated at the surgical site (incision line, ovarian pedicles and uterus). End-tidal isoflurane concentration (FE'ISO), recorded at specific time points during surgery, was adjusted to inhibit autonomic responses to surgical stimulation. Pain was assessed using an Interactive Visual Analog Scale (IVAS), UNESP-Botucatu Multidimensional Composite Pain Scale (MCPS), and mechanical nociceptive thresholds (MNT) up to 24 h post-extubation. Rescue analgesia was provided with intramuscular morphine (0.1 mg/kg) when MCPS was ≥6.Results: Area under the curve (AUC) of FE'ISO was significantly lower (P < 0.0001) in the RM (17.8 ± 3.1) compared to S (23.1 ± 2.2) and R groups (22.8 ± 1.1). Hypertension (systolic arterial pressure > 160 mmHg) coinciding with surgical manipulation was observed only in cats treated with S and R (4/15 cats, P = 0.08). The number of cats receiving rescue analgesia (4 cats in the S group and 1 cat in the R and RM groups) did not differ among groups (P = 0.17). The AUC of IVAS, MCPS and MNT did not differ among groups (P = 0.56, 0.64, and 0.18, respectively). Significantly lower IVAS pain scores were recorded at 1 h in the RM compared to the R and S groups (P = 0.021-0.018). There were no significant adverse effects during the study period. Conclusions: Local infiltration with RM decreased intraoperative isoflurane requirements and resulted in some evidence of improved analgesia during the early postoperative period. Neither R nor RM infiltration appeared to result in long term analgesia in cats undergoing ovariohysterectomy.

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Comparison of intraperitoneal ropivacaine and bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy

Cited by 25 publications

References 12 publications

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

Local and regional anaesthesia in dogs and cats: Descriptions of specific local and regional techniques (Part 2)

Comparison of perioperative analgesia using the infiltration of the surgical site with ropivacaine alone and in combination with meloxicam in cats undergoing ovariohysterectomy

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