Comparison of intraosseous, intramuscular, and intravenous administration of succinylcholine

Moore, Gregory P.; Pace, Steven; Busby, W. Darrell

doi:10.1097/00006565-198912000-00001

Cited by 15 publications

(6 citation statements)

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“…No studies currently exist describing the pharmacokinetic profile of atracurium when routes of administration other than iv are used, but alternative neuromuscular blocking drugs (succinylcholine, pancuronium and alcuronium) can result in systemic effects when administered extravascularly (Moore et al . 1989, Iwasaki et al . 1992, Mikaelian et al .…”

Section: Discussionmentioning

confidence: 99%

Generalised neuromuscular blockade after intraurethral administration of atracurium besilate in a male cat with urethral obstruction

Casoria¹,

Felisberto²,

Auckburally³

et al. 2023

J of Small Animal Practice

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A 4‐year‐old, entire, male, domestic long‐haired cat was presented with an acute history of stranguria and dysuria and diagnosed with urolithiasis causing urethral obstruction. The patient was induced to general anaesthesia and several unsuccessful attempts to flush the uroliths retrogradely towards the bladder were made. An intraurethral administration of the neuromuscular blocking agent atracurium was performed as it has been reported to facilitate urethral catheterisation without any side effects. Respiratory arrest developed after 15 minutes from atracurium administration, which was promptly recognized and treated with mechanical ventilation. The absence of muscle contraction in response to a nerve stimulation confirmed a generalised muscle blockade. Approximately 35 minutes after, a muscle response to nerve stimulation appeared. Neostigmine combined with glycopyrrolate was administered resulting in complete recovery from neuromuscular blockade. In conclusion, the use of intraurethral atracurium can result in systemic absorption of the drug with subsequent generalised neuromuscular blockade.

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Section: Discussionmentioning

confidence: 99%

Generalised neuromuscular blockade after intraurethral administration of atracurium besilate in a male cat with urethral obstruction

Casoria¹,

Felisberto²,

Auckburally³

et al. 2023

J of Small Animal Practice

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show abstract

“…Moore et al [16] evaluated the time to respiratory arrest and loss of forefoot twitch in sheep after administration of succinylcholine (one mg/kg) via the IO, IV, and intramuscular (IM) routes. The time to respiratory arrest was 30.8 ± 7.3 seconds with IV administration, 57.5 ± 10.3 seconds with IO administration, and 230 ± 106 seconds with IM administration.…”

Section: Discussionmentioning

confidence: 99%

The use of intraosseous infusions in the operating room

Joseph¹,

Tobias²

2008

Journal of Clinical Anesthesia

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“…Animal studies [19] have verified the similarity between intravenous and intra‐osseous suxamethonium. Six sheep were anaesthetised on three separate occasions, each time receiving intra‐osseous, intravenous or intramuscular suxamethonium.…”

Section: The Intra‐osseous Routementioning

confidence: 97%

Which port in a storm? Use of suxamethonium without intravenous access for severe laryngospasm

Walker¹,

Sutton²

2007

Anaesthesia

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Comparison of intraosseous, intramuscular, and intravenous administration of succinylcholine

Cited by 15 publications

References 0 publications

Generalised neuromuscular blockade after intraurethral administration of atracurium besilate in a male cat with urethral obstruction

Generalised neuromuscular blockade after intraurethral administration of atracurium besilate in a male cat with urethral obstruction

The use of intraosseous infusions in the operating room

Which port in a storm? Use of suxamethonium without intravenous access for severe laryngospasm

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