Comparison of Intraoperative Indocyanine Green Angiography and Digital Subtraction Angiography for Clipping of Intracranial Aneurysms

Doss, Vinodh T; Goyal, Nitin; Humphries, William; Hoit, D; Arthur, Adam S; Elijovich, Lucas

doi:10.1159/000381148

Cited by 17 publications

(15 citation statements)

References 24 publications

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“…For optical tumor imaging, Near infrared (NIR) dyes are favorable due to their deep penetration in tissues. Indocyanine green (ICG) is the only FDA approved NIR dye and has been used for full antibody labeling [ 33 , 34 ]. But its hydrophobic property limits its application in scFv labeling because scFv is not well tolerant to organic solvents.…”

Section: Discussionmentioning

confidence: 99%

A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer

Han

Han³

et al. 2016

Oncotarget

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Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer related death in men. The early diagnosis and treatment of PCa are still challenging due to the lack of efficient tumor targeting agents in traditional managements. Prostate specific membrane antigen (PSMA) is highly expressed in PCa, while only has limited expression in other organs, providing an ideal target for the diagnosis and therapy of PCa. The antibody library technique has opened the avenue for the discovery of novel antibodies to be used in the diagnosis and therapy of cancer. In this paper, by screening a large yeast display naive human single chain antibody fragment (scFv) library, we obtained a high affinity scFv targeting PSMA, called gy1. The gy1 scFv was expressed in E.coli and purified via a C terminal 6His tag. The binding affinity of gy1 was shown to be at the nanomolar level and gy1 can specifically bind with PSMA positive cancer cells, and binding triggers its rapid internalization through the endosome-lysosome pathway. The specific targeting of gy1 to PSMA positive tumor tissues was also evaluated in vivo. We showed that the IRDye800CW labeled gy1 can efficiently target and specifically distribute in PSMA positive tumor tissues after being injected into xenograft nude mice. This study indicated that the novel antibody gy1 could be used as a great tool for the development of PSMA targeted imaging and therapy agents for PCa.

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Section: Discussionmentioning

confidence: 99%

A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer

Han

Han³

et al. 2016

Oncotarget

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“…[4,[7][8][9][10] The discordance between ICG-VA and intraoperative DSA reported by Caplan et al [11] was 10.8%, whereas Washington et al [12] reported this to be 14.3%. The incidence of discordance between ICG-VA and postoperative DSA reported by Doss et al [13] was 21.07%. In our study, the discordance between ICG-VA and postoperative DSA was 6.7% and is statistically significant (P <0.0001).…”

Section: Discussionmentioning

confidence: 80%

“…The incidence of discordance between ICG-VA and postoperative DSA reported by Doss et al . [ 13 ] was 21.07%. In our study, the discordance between ICG-VA and postoperative DSA was 6.7% and is statistically significant ( P < 0.0001).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Efficacy of Intraoperative Indocyanine Green Videoangiography in Clipping of Anterior Circulation Aneurysms with Postoperative Digital Subtraction Angiography

Kumar

Jagetia

Singh

et al. 2017

Journal of Neurosciences in Rural Practice

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Introduction:The aim of this study is to assess the efficacy of intraoperative indocyanine green videoangiography (ICG-VA) using postoperative digital subtraction angiography (DSA) in clipped anterior circulation aneurysms.Materials and Methods:A prospective study was conducted for 1 year which included thirty patients of anterior circulation aneurysm treated by clipping of aneurysm. Intraoperative ICG-VA was performed on all the patients. Postoperative DSA was performed to assess the efficacy of ICG-VA.Results:Intraoperative ICG-VA revealed the occlusion of aneurysm in all the thirty patients. Postoperative DSA revealed aneurysm neck remnant in two patients and demonstrated no branch occlusion.Conclusions:Intraoperative ICG-VA is useful in assessing the completeness of clipping of cerebral aneurysms and ensures patency of branch vessels, thus providing a better postoperative outcome. It replaces the need for invasive postoperative angiographic imaging in a selected group of patients and is also cost effective.

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“…ICG angiography has complication rate of less than 0.1% 28 , 29 . The discordance between ICG and intraoperative digital subtraction angiography (DSA) in previous series were reported to be in the range of 10–20% 30 – 32 . A recent study has shown to be correlating with post-operative DSA findings in almost 97% of cases 23 .…”

Section: Discussionmentioning

confidence: 97%

A pilot study on assessing the role of intra-operative Flow 800 vascular map model in predicting onset of vasospasm following micro vascular clipping of ruptured intracranial aneurysms

Munakomi

Poudel

2018

F1000Res

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Objective To ascertain the predictive value of intra-operative FLOW 800 vascular map model in predicting onset of post-operative clinical vasospasm and delayed cerebral ischemia among patients undergoing micro-vascular clipping of ruptured intracranial aneurysms. Material and methods A total of 40 patients were enrolled in the study and their variables such as age, World Federation of Neurological Surgeons (WFNS) grade at presentation, Computerized Tomography (CT) Fisher grading, location of the aneurysms, and Indocyanine Green (ICG) flow status were compared and statistically analyzed along with differences in Absorption Intensities (AI) and difference in time lag values obtained from the FLOW 800 vascular map studies for predicting onset of vasospasm. Results The Receiver Operating curve (ROC) of the model for predicting post-operative vasospasm was highest (.892) for difference in the AI followed by CT Fisher grading (.778), difference in time lag (.700) and WFNS grading (.699).Analysis of variance for different variables studied in our model for predicting vasospasm was significant for all except for age (.991) and the ICG flow through the parent vessel (.079).Multivariate analysis done for predicting the vasospasm was significant for all variables except for age (.869) and ICG main flow (.196) Conclusion Our study confirmed the role of FLOW 800 study model in predicting clinical vasospasm. Inclusion of this entity would therefore help in taking timely and correct therapeutics measures to ensure better patient outcomes.

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Comparison of Intraoperative Indocyanine Green Angiography and Digital Subtraction Angiography for Clipping of Intracranial Aneurysms

Cited by 17 publications

References 24 publications

A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer

A novel anti-PSMA human scFv has the potential to be used as a diagnostic tool in prostate cancer

Comparison of Efficacy of Intraoperative Indocyanine Green Videoangiography in Clipping of Anterior Circulation Aneurysms with Postoperative Digital Subtraction Angiography

A pilot study on assessing the role of intra-operative Flow 800 vascular map model in predicting onset of vasospasm following micro vascular clipping of ruptured intracranial aneurysms

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