Comparison of intraocular pressure and pupil diameter after sedation with either acepromazine or dexmedetomidine in healthy dogs

Micieli, Fabiana; Chiavaccini, Ludovica; Lamagna, Barbara; Vesce, Giancarlo; Santangelo, Bruna

doi:10.1016/j.vaa.2018.05.003

Cited by 11 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, the use of medetomidine‐methadone resulted in a significant reduction in PS. The results match those of previous studies 7 10 17. To date, there are no reports that fully explain the miosis mechanism caused by α 2 adrenergic agonists in dogs.…”

Section: Discussionsupporting

confidence: 91%

“…16 In the same way, it has been shown that a lower dose of dexmedetomidine (2 µg/kg) intravenously did not change IOP over time, which is similar to the results of the present study. 17 As the protocol in this study combined medetomidine and methadone, these drugs could not be evaluated separately nor could the findings be directly compared with previously published studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of fentanyl on intraocular pressure and pupil size in medetomidine‐methadone premedicated dogs: a pilot study

Gomez-Martinez

Varela

Fontalba-Navas

et al. 2020

Veterinary Record Open

View full text Add to dashboard Cite

BackgroundThis is a pilot study to evaluate the effects of fentanyl on intraocular pressure (IOP) and pupil size (PS) in dogs premedicated with medetomidine and methadone.MethodsSixteen dogs with a median (first quartile–third quartile) age of 3.5 (1.25–6) years and a mean (sd) weight of 18.6 (9.2) kg were included. Baseline readings of IOP and PS were recorded before all dogs were premedicated intramuscularly with medetomidine (10 µg/kg) and methadone (0.5 mg/kg). Both measurements were repeated 15 and 30 minutes later. Following this, the dogs were randomly assigned into two groups. The fentanyl group received intravenous fentanyl (10 µg/kg), while the control group received the same volume of saline solution intravenously. IOP and PS measurements were measured and recorded in both groups at one, five and ten minutes after intravenous injection. Data were analysed with one-way and two-way repeated-measures analysis of variance or their non-parametric equivalents.ResultsPS was significantly decreased 15 and 30 minutes following intramuscular premedication and IOP was significantly increased in the fentanyl group at all time points following intravenous administration.ConclusionsMedetomidine, methadone and fentanyl combinations are not recommended for use in patients where an increase in IOP or decrease in PS is undesirable.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of fentanyl on intraocular pressure and pupil size in medetomidine‐methadone premedicated dogs: a pilot study

Gomez-Martinez

Varela

Fontalba-Navas

et al. 2020

Veterinary Record Open

View full text Add to dashboard Cite

show abstract

“…In a study by Micieli et al. (2018), which separately examined the visual effects of intravenous injection of 0.015 mg/kg of Acepromazine and 0.002 mg/kg of Dexmedetomidine, there was a significant reduction in pupil diameters in both groups. Similar results were obtained in a study by Artigas et al.…”

Section: Discussionmentioning

confidence: 99%

“…Artigas et al (2012) mentioned similar reasons for the reduction in intraocular pressure after the administration of alpha-2 agonists. Micieli et al (2018) examined the separate eye effects of intravenous injection of two drugs, Dexmedetomidine and Acepromazine, on dogs at 2 µg/kg and 0.015 µg/kg during 25 min. In their study, the intramuscular injection of Dexmedetomidine compared with Acepromazine significantly reduced intraocular pressure at 10 and 15 hr after injection.…”

Section: Ta B L Ementioning

confidence: 99%

“…In this study, a decrease was seen in pupil diameters in all four groups, but the reduction was only significant in DA and MA groups. In a study by Micieli et al (2018), which separately examined the visual effects of intravenous injection of 0.015 mg/kg of Acepromazine and 0.002 mg/kg of Dexmedetomidine, there was a significant reduction in pupil diameters in both groups. Similar results were obtained in a study by Artigas et al (2012) in 2012, after the intravenous injection of 0.005 mg/kg of Dexmedetomidine, and a study by Mrazova et al (2018), after the separate intravenous injection of 0.01 mg/kg of Medetomidine and 0.02 mg/kg of Acepromazine.…”

Section: Ta B L Ementioning

confidence: 99%

See 1 more Smart Citation

Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs

Aghababaei

Ronagh

Mosallanejad

et al. 2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

Premedicants in cats and dogs: which one should you choose and when?

Murrell¹

2022

In Practice

View full text Add to dashboard Cite

Background: Premedication is an integral part of any anaesthetic protocol and the drugs chosen for premedication will determine the characteristics of the ensuing anaesthetic. Choosing appropriate premedicant drugs for the individual patient is vital to ensure a smooth and stress‐free anaesthetic. Normally, a balanced premedication protocol involving both a sedative and a hypnotic is advocated. This allows the two key aims of premedication – sedation and analgesia – to be met. Synergistic sedation between most sedatives and opioids also means that combining these drugs allows lower doses of each individual agent to be used.Aim of the article: This article discusses how it is important to know the clinical pharmacology of the different drugs used for premedication in order to make a rational decision about premedicant selection. One way to think about premedicant selection is based on the American Society of Anaesthesiologists (ASA) physical status classification system of the cat or dog, whereby the health status of the individual is used to inform about suitable premedication protocols.

show abstract

Comparison of intraocular pressure and pupil diameter after sedation with either acepromazine or dexmedetomidine in healthy dogs

Cited by 11 publications

References 5 publications

Effects of fentanyl on intraocular pressure and pupil size in medetomidine‐methadone premedicated dogs: a pilot study

Effects of fentanyl on intraocular pressure and pupil size in medetomidine‐methadone premedicated dogs: a pilot study

Effects of Medetomidine, Dexmedetomidine and their combination with Acepromazine on the intraocular pressure (IOP), tear secretion and pupil diameter in dogs

Premedicants in cats and dogs: which one should you choose and when?

Contact Info

Product

Resources

About