Comparison of Intralesional Corticosteroid and Propranolol Treatment of Periorbital Infantile Hemangiomas: An Outcome Study of 61 Cases

Hoornweg, Marije J.; Saeed, Peerooz; Tanck, Michael W.T.; Hage, J. Joris; Coumou, Adriaan D.; Horst, Chantal M.A.M. van der

doi:10.5301/ejo.5000467

Cited by 10 publications

(5 citation statements)

References 28 publications

(31 reference statements)

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“…In 2008 Léaute‐Labrèze et al published a series of 11 cases of infantile haemangioma cases managed with propranolol which has revolutionized treatment. Two systematic reviews show both intra‐lesional steroids and propranolol are effective, though less side effects occur with propranolol . Propranolol is now the mainstay of treatment for periorbital infantile haemangioma and intra‐lesional steroids are used as an adjunct in resistant cases.…”

Section: Uses Of Locally Administered Steroidsmentioning

confidence: 99%

Local delivery of corticosteroids in clinical ophthalmology: A review

Fung

Tran

Lim

et al. 2020

Clinical Exper Ophthalmology

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Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the

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Section: Uses Of Locally Administered Steroidsmentioning

confidence: 99%

Local delivery of corticosteroids in clinical ophthalmology: A review

Fung

Tran

Lim

et al. 2020

Clinical Exper Ophthalmology

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“…Glasman et al 19 reported wheezing in 23% of patients, and in 1 patient, wheezing was severe enough to require discontinuation of treatment. Hoornweg et al 20 reported cold extremities in 43% of patients. Painter and Hildebrand 21 reported mild wheezing in 1 patient.…”

Section: Safetymentioning

confidence: 97%

“…In 2014, Hoornweg et al 20 reported on a retrospective case series comparing oral propranolol in 14 patients (maximum dose, 3 mg/kg daily) with intralesional triamcinolone (40 mg/ ml) in 29 patients. The size of the lesion was not measured.…”

Section: Efficacy In Inducing Regression Of Hemangiomamentioning

confidence: 99%

“…Although a reduction in magnitude also was observed in the unaffected eye, that difference was not statistically significant. Hoornweg et al 20 reported that visual acuity was improved and astigmatism reduced, but data to confirm these findings were not reported and no control or comparison group was considered. Herlihy et al 22 reported a 43% reduction in astigmatism in patients treated with propranolol versus a 67% reduction in a historical comparison group that was treated using intralesional corticosteroids.…”

Section: Effect On Induced Astigmatism and Amblyopiamentioning

confidence: 99%

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The Use of β-Blockers for the Treatment of Periocular Hemangiomas in Infants

Hutchinson

Kraker

Pineles³

et al. 2019

Ophthalmology

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“…The overall rate for side effects, based on 48 studies and 3,352 patients, was 7.1% (12, 34-67, 70-72, 74-77, 79, 80, 83-87). Six studies mentioned the need for additional treatment (local or systemic) for adverse events (38,40,45,52,54,69). The aggregated mean and median follow-up lengths were 17.09 and 12 months, respectively.…”

Section: Patients Characteristics and Therapeutic Approachmentioning

confidence: 99%

The Safety of Intralesional Steroid Injections in Young Children and Their Effectiveness in Anastomotic Esophageal Strictures—A Meta-Analysis and Systematic Review

et al. 2022

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ObjectiveIntralesional steroid injections (ISI) are a widely used technique for various pediatric indications and represent a possible adjuvant treatment for anastomotic esophageal strictures. Yet, no consensus has been reached neither on their safety in the pediatric population or their effectiveness in esophageal atresia patients. This systematic review aimed to assess the safety of ISI in young children through a meta-analysis and to summarize the current knowledge on the effectiveness of ISI in anastomotic esophageal strictures.MethodsA systematic literature search was performed in Embase, Medline, Web of Science Core Collection, Cochrane Central Register of Controlled Trials and Google Scholar up to August 16 2021. Studies focusing on ISI and involving children up to 2 years were included in the meta-analysis for the safety assessment. All studies evaluating the use of ISI as adjuvant treatment in anastomotic esophageal strictures in children were included in the systematic review to assess the effectiveness of the intervention.ResultsThe literature search yielded 8,253 articles. A total of 57 studies were included, of which 55 for the safety and five for the effectiveness assessment. The overall complication rate was 7%, with a greater incidence of local complications compared to systemic complications. Six studies (with a total of 367 patients) evaluated adrenocorticotropic hormone and cortisol levels, of which four reported hypothalamic-pituitary axis suppression. Two children (0.6%) received replacement therapy and all patients recovered uneventfully. A mean number of 1.67 ISI were performed per esophageal atresia (EA) patient. A reduction of needed dilatations was seen after ISI, compared to the number of dilatations performed before the intervention (5.2 vs. 1.3).ConclusionThe insufficient data emphasized the need for further prospective and comparative studies. Results from this meta-analysis and systematic review address ISI as a safe and effective technique. Close clinical follow-up and growth curve evaluation are advisable in patients receiving ISI.Systematic Review RegistrationPROSPERO, identifier: CRD42021281584.

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Comparison of Intralesional Corticosteroid and Propranolol Treatment of Periorbital Infantile Hemangiomas: An Outcome Study of 61 Cases

Cited by 10 publications

References 28 publications

Local delivery of corticosteroids in clinical ophthalmology: A review

Local delivery of corticosteroids in clinical ophthalmology: A review

The Use of β-Blockers for the Treatment of Periocular Hemangiomas in Infants

The Safety of Intralesional Steroid Injections in Young Children and Their Effectiveness in Anastomotic Esophageal Strictures—A Meta-Analysis and Systematic Review

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