Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation

Kürkçüoğlu, Bekir Suat; DÖNMEZ, Melehat; Altınel, Seher; Akıncı, Seda Banu; Saricaoglu, Fatma; Aypar, Ülkü

doi:10.3906/sag-1302-32

Cited by 9 publications

(7 citation statements)

References 21 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, synovitis promotes the production of pain neurotransmitters, such as nerve growth factor and bradykinin (19). At the same time, synovitis promotes synovial angiogenesis, which in turn accelerates inflammation and leads to SF directly (20).…”

Section: Synovial Fibrosis and Synovitismentioning

confidence: 99%

“…Usually, SF appears in the later stages of OA, which is different from synovitis. But in a study examining the effects of the intra-articular application of bupivacaine and levobupivacaine, inflammation and late fibrosis were found shortly after injection, suggesting that synovitis promotes fibrosis ( 21 ). On the other hand, as an aseptic chronic inflammatory disease, SF may be the inevitable outcome of “damage-repair,” and thus it can be emphasized that synovial inflammation drives the development of fibrosis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synovial Fibrosis Involvement in Osteoarthritis

et al. 2021

View full text Add to dashboard Cite

Bone changes have always been the focus of research on osteoarthritis, but the number of studies on synovitis has increased only over the last 10 years. Our current understanding is that the mechanism of osteoarthritis involves all the tissues that make up the joints, including nerve sprouting, pannus formation, and extracellular matrix environmental changes in the synovium. These factors together determine synovial fibrosis and may be closely associated with the clinical symptoms of pain, hyperalgesia, and stiffness in osteoarthritis. In this review, we summarize the consensus of clinical work, the potential pathological mechanisms, the possible therapeutic targets, and the available therapeutic strategies for synovial fibrosis in osteoarthritis to gain insight and provide a foundation for further study.

show abstract

Section: Synovial Fibrosis and Synovitismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synovial Fibrosis Involvement in Osteoarthritis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Owing to the design of the present study, we were unable to assess whether sevoflurane could cause any type of transient acute toxicity to the joint. Previously, neutrophil infiltration has been observed the day after single intra-articular injections of conventional local anesthetics such as levobupivacaine, 29,41 bupivacaine, or procaine 30 ; however, neutrophils were not observed beyond day 7. Nevertheless, we aimed to simulate the clinical conditions associated with the treatment of septic arthritis.…”

Section: Discussionmentioning

confidence: 96%

Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats

et al. 2022

View full text Add to dashboard Cite

Objectives We investigated the effects of repeated intra-articular injections of liquid sevoflurane to articular structures, as this inhalational anesthetic is being repurposed as an antimicrobial agent, which would make sevoflurane a novel alternative for the treatment of septic arthritis. Methods The left knees of nine Sprague-Dawley rats were injected with 150 μL of liquid sevoflurane for five consecutive days, whereas the right knees were injected with the same volume of saline to serve as controls. Animals were examined daily for clinical signs of local and systemic toxic effects attributable to sevoflurane. Rats were euthanized in groups of three at days 7, 14, and 35 after the first injection, and left and right knees were sent for histological assessment. Results Local signs on knees consisted of transient bilateral scabs, and an unexpected subcutaneous emphysema affecting only left knees, which was attributed to sevoflurane. No rat presented with limp, and animal welfare was good during the study period. Two out of the three left knees from rats sacrificed at day 7 showed mild histological changes, specifically a mild infiltration of lymphocytes. All other seven left knees as well as all nine right knees were completely normal at histological examination. Conclusion We concluded that repeated intra-articular injections of sevoflurane seemed safe for articular structures in noninfected knees. Further studies focused on the safety of intra-articular sevoflurane in infected knees, as well as on its effectiveness for the treatment of septic arthritis are warranted.

show abstract

“…On the other hand, there are studies reporting histological alterations in cartilage or synovium after intra-articular anesthetic administration in vivo. The most common finding is neutrophil infiltration on the first day after the injection [ 14 , 22 ]. Inflammatory responses may be observed during the fifth and tenth days after the injection [ 8 , 22 - 23 ].…”

Section: Discussionmentioning

confidence: 99%

The In Vivo Chondrotoxicity of Single Intra-articular Injection of Local Anesthetic in Rat Cartilage

Vrachnis,

Gliatis,

Papachristou

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction A constant infusion of local anesthetics through pain pumps has been shown to cause chondrolysis. However, there is no general consensus regarding the safety of a single intra-articular injection of local anesthetics. In this experimental study, we examined the rat cartilage for possible histological effects after a single intra-articular administration of lidocaine or ropivacaine. Material and methods Thirty-two male Sprague-Dawley rats, weighing 250-300 grams, were divided into two groups of 16 each. We injected 0.1 ml of either lidocaine 2% (20 mg/ml) or ropivacaine 0.75% (7.5 mg/ml) into the left knee of the rats. The right knee in both groups was used as a control, and an equal amount of normal saline was injected. Each group was further divided into subgroups of four, which were euthanized after one, seven, 21, and 60 days after the initial injection. Knees were excised and prepared for histopathological analysis. A modified version of the Mankin score was used for cartilage damage evaluation. Results No difference regarding cartilage damage was detected after the examination under light microscopy between lidocaine, ropivacaine, and placebo in all specimens. Time elapsed since the initial injection did not affect the results at any time point. Conclusion A single intra-articular injection of local anesthetic did not induce any histological changes in the rat cartilage. Further research is needed to demonstrate the safety of humans.

show abstract

Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation

Cited by 9 publications

References 21 publications

Synovial Fibrosis Involvement in Osteoarthritis

Synovial Fibrosis Involvement in Osteoarthritis

Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats

The In Vivo Chondrotoxicity of Single Intra-articular Injection of Local Anesthetic in Rat Cartilage

Contact Info

Product

Resources

About