Comparison of inpatients with major mental illness who do and do not consent to low-risk research

Issues with recruitment to randomised controlled trials in the drug and alcohol field: a literature review and Australian case study

“…Poor recruitment rates result in increased financial burdens, extended duration of recruitment, a reduction in statistical power and, in some cases, studies may be discontinued [16,17]. The characteristics of subjects recruited have also been found to influence the generalisability of findings [18]. On review of the literature, problems with recruitment to RCTs can be categorised largely into two distinct groups: barriers for patients and barriers for staff [19].…”

Reviews: Emerging Empirical Evidence on the Ethics of Schizophrenia Research

“…165 Although limited data exist regarding the differences between individuals who do and do not agree to participate in research-in part, because it is difficult to conduct these kinds of studies-the data that do exist tend to support the notion that patients with schizophrenia are fundamentally similar to patients with medical illnesses. 172,198,199,201,202 For example, Candilis and colleagues' novel work on this issue indicates that patients with schizophrenia and schizoaffective disorder provide a combination of socially directed and personally motivated reasons for research participation. Because this hypothetical study related to an antibiotic trial, rather than a trial of antipsychotic medication, it would be interesting to learn more about motivations for participation decisions related specifically to psychiatric trials, particularly as risks escalate.…”

Sample bias from different recruitment strategies in a randomised controlled trial for alcohol dependence

“…However, an important condition of sound empirical research is that the results are generalisable from the study sample to the larger population of concern [1]. Selection bias may significantly limit generalisability if the study is based on a limited population with differing socio‐demographic and/or clinical factors [2]. The recruitment method is one of the most important aspects that determines the probability of attaining generalisable results [1].…”