Comparison of Inhibitory Effect of Curcumin Nanoparticles and Free Curcumin in Human Telomerase Reverse Transcriptase Gene Expression in Breast Cancer

Kazemi‐Lomedasht, Fatemeh; Rami, Abbas; Zarghami, Nosratollah

doi:10.5681/apb.2013.021

Cited by 16 publications

(5 citation statements)

References 10 publications

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“…Telomerase activity is usually detected in most cancer cells and is critical for cancer cell development [73]. However, deactivation of telomerase activity is one of the important strategies to inhibit cancer development.…”

Section: Telomerasementioning

confidence: 99%

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways

Almatroudi

Allemailem

Alwanian

et al. 2023

IJMS

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Cancer is the principal cause of death and its incidence is increasing continuously worldwide. Various treatment approaches are in practice to treat cancer, but these treatment strategies may be associated with severe side effects and also produce drug resistance. However, natural compounds have established their role in cancer management with minimal side effects. In this vista, kaempferol, a natural polyphenol, mainly found in vegetables and fruits, has been revealed to have many health-promoting effects. Besides its health-promoting potential, its anti-cancer potential has also been described in in vivo as well as in in vitro studies. The anti-cancer potential of kaempferol has been proven through modulation of cell signaling pathways in addition to the induction of apoptosis and cell cycle arrest in cancer cells. It leads to the activation of tumor suppressor genes, inhibition of angiogenesis, PI3K/AKT pathways, STAT3, transcription factor AP-1, Nrf2 and other cell signaling molecules. Poor bioavailability of this compound is one of the major limitations for its proper and effective disease management actions. Recently, some novel nanoparticle-based formulations have been used to overcome these limitations. The aim of this review is to provide a clear picture regarding the mechanism of action of kaempferol in different cancers through the modulation of cell signaling molecules. Besides this, strategies to improve the efficacy and synergistic effects of this compound have also been described. However, more studies are needed based on clinical trials to fully explore the therapeutic role of this compound, especially in cancer treatment.

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Section: Telomerasementioning

confidence: 99%

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways

Almatroudi

Allemailem

Alwanian

et al. 2023

IJMS

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“…Yallapu et al [ 55 ] found that the cellular uptake of curcumin-CD complexes improved in DU145 prostate cancer cell lines when compared to that of the free bioactive. Curcumin complexes decrease the size of tumors in a xenograft mouse model of lung cancer [ 56 ] and Kazemi-Lomedasht [ 57 ] have reported that the curcumin-β-inclusion complex shows improved curcumin uptake in T47D breast cancer cells and an important decrease in the level of telomerase gene expression in comparison to cells treated with the free compound. It was also reported that curcumin-CD complexes minimize the rates of cancer cell migration by 75.5% (a two-fold increase when compared with that of free curcumin) and enhance apoptosis rates by 26.3% (again, a two-fold increase compared to that of free curcumin) [ 58 ].…”

Section: Antioxidant-loaded Delivery Systems As Emerging Therapeutic ...mentioning

confidence: 99%

Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

et al. 2023

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Cancer is one of the major diseases leading to death worldwide, and the fight against the disease is still challenging. Cancer diseases are usually associated with increased oxidative stress and the accumulation of reactive oxygen and nitrogen species as a result of metabolic alterations or signaling aberrations. While numerous antioxidants exhibit potential therapeutic properties, their clinical efficiency against cancer is limited and even unproven. Conventional anticancer antioxidants and drugs have, among others, the great disadvantage of low bioavailability, poor targeting efficiency, and serious side effects, constraining their use in the fight against diseases. Here, we review the rationale for and recent advances in potential delivery systems that could eventually be employed in clinical research on antioxidant therapy in cancer. We also review some of the various strategies aimed at enhancing the solubility of poorly water-soluble active drugs, including engineered delivery systems such as lipid-based, polymeric, and inorganic formulations. The use of cyclodextrins, micro- and nanoemulsions, and thermosensitive smart liposomes as useful systems for the delivery and release of poorly aqueous-soluble drugs, improving their bioactivity and stability, is also addressed. We also provide some details on their formulation processes and their use in a variety of medical applications. Finally, we briefly cover a case study specifically focused on the use of delivery systems to minimize oral cancer and associated dental problems.

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“…Curcumin is the most important component of the rhizomes of Curcuma longa L. (turmeric) and has a great bioactive potential with antitumor, antioxidant, and anti-inflammatory properties [ 37 ]. The anticancer activity of this compound is associated with the mechanism of action that induces apoptosis and inhibits tumor proliferation and invasion by suppressing a variety of cell signaling pathways.…”

Section: Overview Of Polyphenols and Their Anticancer Propertiesmentioning

confidence: 99%

Section: Overview Of Polyphenols and Their Anticancer Propertiesmentioning

confidence: 99%

“…In a study by Kazemi-Lomedasht et al (2013) [ 37 ], curcumin showed anticancer effects against T47D breast cancer cells. The extract of curcumin prepared at the concentration of 22 μM increased the inhibition of the telomerase gene expression in the T47D cell line and decreased cell viability by 50% in 48 h [ 37 ]. On the other hand, testing for the cervical cancer cell line HeLa at a concentration of 34.23 μM/mL reduced cell proliferation and inhibited NF-kB and Wnt signaling pathways, resulting in cell death [ 16 ].…”

Section: Overview Of Polyphenols and Their Anticancer Propertiesmentioning

confidence: 99%

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Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Vieira,

Tessaro,

Lima

et al. 2023

Nutrients

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Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative nanotechnologies have been applied to encapsulate these compounds, aiming to improve their efficacy against cancer. In this comprehensive review, we evaluate the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer using in vitro studies and in vivo preclinical models, highlighting recent advancements in the field. It was found that polymeric nanomaterials, lipid-based nanomaterials, inorganic nanomaterials, and carbon-based nanomaterials are the most used classes of nanocarriers for encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity and pro-apoptotic effects, particularly against breast, lung, prostate, cervical, and colorectal cancer cells, surpassing the performance of free bioactive compounds. Preclinical trials in xenograft animal models have revealed decreased tumor growth after treatment with polyphenol-loaded delivery systems. Moreover, the interaction of polyphenol co-delivery systems and polyphenol–drug delivery systems is a promising approach to increase anticancer activity and decrease chemotherapy side effects. These innovative approaches hold significant implications for the advancement of clinical cancer research.

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Comparison of Inhibitory Effect of Curcumin Nanoparticles and Free Curcumin in Human Telomerase Reverse Transcriptase Gene Expression in Breast Cancer

Cited by 16 publications

References 10 publications

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways

Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

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