Comparison of inhaled albuterol powder and aerosol in asthma*1

Bronsky, Edwin A.; Bucholtz, Gerald A.; Busse, William W.; Chervinsky, Paul; Condemi, John J.; Ghafouri, Mo; Hudson, Leonard D.; Lakshminarayan, S.; Lockey, Richard F.; Reese, Marshall E.; Rennard, Stephen I.; Segal, Allen T.; Smolley, Laurence; Spector, Sheldon L.; Stablein, John J.; As, Andre van; Wilson, Archie F.

doi:10.1016/0091-6749(87)90205-3

Cited by 36 publications

(23 citation statements)

References 5 publications

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“…The increase in percentage of PEFR was significant in both the groups but inter group analysis showed that both devices were equally effective in delivering β 2 agonist in the management of acute exacerbation of asthma. This is in accordance with two previous studies 20,21 but a study done by Golish J 22 showed results contrary to this. More acceptability of DPI in paediatric population was shown by a study 23 even though clinical efficacy of both the devices was same.…”

Section: Discussioncontrasting

confidence: 54%

Comparative study of rotahaler with metered dose inhaler in administering salbutamol in children with bronchial asthma

Balaji

Kamalammal

2016

Int J Contemp Pediatr

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Section: Discussioncontrasting

confidence: 54%

Comparative study of rotahaler with metered dose inhaler in administering salbutamol in children with bronchial asthma

Balaji

Kamalammal

2016

Int J Contemp Pediatr

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“…An NEB system may require a much larger dose of medication to produce equivalent bronchodilation compared with other formulations [5]. Some pharmacodynamic and clinical studies have been undertaken to determine the comparative efficacy of an MDI with or without a large-volume spacer, DPI and NEB [6, 7, 8, 9, 10, 11, 12, 13], but there are few well-controlled studies simultaneously comparing the effects of these three devices using salbutamol.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Bronchodilator Effects of Salbutamol Delivered via a Metered-Dose Inhaler with Spacer, a Dry-Powder Inhaler, and a Jet Nebulizer in Patients with Chronic Obstructive Pulmonary Disease

Ikeda

Nishimura²,

Koyama³

et al. 1999

Respiration

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The aim of this study was to compare the bronchodilator effects of salbutamol delivered via three different devices: a dry-powder inhaler (DPI), a metered-dose inhaler (MDI) with a large-volume spacer and a jet nebulizer (NEB) in patients with stable chronic obstructive pulmonary disease (COPD). Ten male patients with stable COPD [age: 67.2 ± 3.8 years, forced expiratory volume in 1 s (FEV₁): 1.56 ± 0.32 liters] were studied in a randomized, double-blind and crossover manner. Each patient received 200 or 1,000 µg salbutamol via an MDI with an InspirEase^TM spacer, a Rotahaler^TM, or a DeVilbiss 646^TM nebulizer (NEB), or matching placebo on 7 separate days. Spirometry was performed before and 15, 30, 60, 90, 120, and 240 min after inhalation. With the 200-µg dose, only DPI produced a small but greater response in maximum FEV₁ and in area under the time-response curve (AUC-FEV₁) compared with placebo. With the 1,000-µg dose, DPI and MDI produced equally greater improvements in both maximum FEV₁ and AUC–FEV₁ than NEB. An equal bronchodilating effect can be obtained using either DPI or MDI with a spacer device, whereas the NEB was less effective when the same dose was administered.

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“…As these dry powder inhalers are breath-actuated and hence no propellants are needed, they are easier to handle by the elderly and children. Co-ordination of inhalation technique with opening pressure valve (press and breath manoeuvre) is not required [4, 5, 7, 8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Clinical Equivalence Trial on Budesonide Delivered either by the Novolizer<sup>®</sup> Multidose Dry Powder Inhaler or the Turbuhaler<sup>®</sup> in Asthmatic Patients

Ag¹,

Kremer

Metzenauer

et al. 2002

Respiration

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Background and Objectives: To investigate the therapeutic equivalence of the two formulations of the glucocorticosteroid budesonide delivered either by the budesonide Novolizer^®, i.e. a multidose dry powder inhaler, or by the Pulmicort^® Turbuhaler^® in asthmatic patients in terms of efficacy, safety and tolerability during a 12-week treatment. Methods: A total of 315 patients were randomised in this open, multicentre study. Inclusion criteria comprised previously diagnosed bronchial asthma of mild to moderate persistent intensity (ranging from 60% to a maximum of 90% predicted FEV₁), need for anti-inflammatory therapy, inhalation of β₂-sympathomimetics on an as needed to regular basis, reversibility of airway obstruction of >12% after inhalation of 2 actuations of 100 µg salbutamol. Primary variable was FEV₁, secondary were other pulmonary function test variables, PC₂₀FEV₁ for histamine challenge, morning and evening PEFR, salbutamol usage, asthma symptoms, reactions after inhalation, standard safety variables. Results: The comparison of the FEV₁ at study endpoint indicated that the Novolizer^® was at least as efficacious as the Turbuhaler^® (p < 0.001). All other variables of the pulmonary function tests as well as the asthma symptoms, nocturnal awakenings, PEFR measurements, or salbutamol usage indicated no relevant difference. Only 1 patient (Turbuhaler^®) discontinued prematurely due to lack of efficacy. None of the other safety variables (adverse events, laboratory variables, vital signs, etc.) indicated any difference between the groups. Conclusions: The budesonide Novolizer^® is therapeutically equivalent to the Pulmicort^® Turbuhaler^® for the long-term treatment of patients with mild to moderate persistent asthma.

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Comparison of inhaled albuterol powder and aerosol in asthma*1

Cited by 36 publications

References 5 publications

Comparative study of rotahaler with metered dose inhaler in administering salbutamol in children with bronchial asthma

Comparative study of rotahaler with metered dose inhaler in administering salbutamol in children with bronchial asthma

Comparison of the Bronchodilator Effects of Salbutamol Delivered via a Metered-Dose Inhaler with Spacer, a Dry-Powder Inhaler, and a Jet Nebulizer in Patients with Chronic Obstructive Pulmonary Disease

Clinical Equivalence Trial on Budesonide Delivered either by the Novolizer<sup>®</sup> Multidose Dry Powder Inhaler or the Turbuhaler<sup>®</sup> in Asthmatic Patients

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