COMPARISON OF INFLUENCE OF VARIOUS REGIMENS OF DRUG INTAKE ON 24 HOUR bLOOD  PRESSURE, CENTRAL AORTIC PRESSURE AND VASCULAR WALL STIFFNESS IN SYSTEMIC  HYPERTENSION PATIENTS WITH ISCHEMIC STROKE

Скибицкий, В. В.; Фендрикова, А. В.; Опольская, С. В.

doi:10.15829/1560-4071-2018-4-56-66

Cited by 5 publications

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References 14 publications

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“…11 (10)(11)(12)(13)(14) 10 (9 (11,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)2) 18 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) 0,04 Значение показателей жесткости сосудистой стенки PWVao, м / с 10 (9,7-10,4) 10,4 (9,(8)(9)(10)8) нд 12,4 (11,3-13,2) 12,5 (11,(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)3) нд PWVao пр., м / ...…”

Section: результатыunclassified

“…11 (10)(11)(12)(13)(14) 9 (6-11) -10,0* 10 (9-12) 9 (5 10 (9,7-10,4) 9,2 (9-10) -4,5* 10,4 (9,(8)(9)(10)8) 9 (8,6-9,7) -12,2* 0,01 PWVao пр., м / с 9,7 (9,2-10,2) 9,5 (9-9,8) -2,1* 9,9 (9,1-10,2) 12 (11)(12)(13)(14)(15) 11 (10)(11)(12)(13) -9,1* 15 (13)(14)(15)(16)(17) 10 7-11-36,4* <0,001 ВарДАДао, мм рт. ст.…”

Section: результатыunclassified

“…14 (10)(11)(12)(13)(14)(15)(16) 11 (9)(10)(11)(12)(13)(14) -10* 12 (10)(11)(12)(13)(14)(15)(16) 9 (5)(6)(7)(8)(9)(10)(11) -28,6* 0,001 Δ% -разница (в %) между показателями до и через 12 месяцев лечения; p Δ1-2 -достоверность различий степени изменения показателей СМАД через 12 месяцев терапии между группой 1и группой 2, * -p<0,05 -достоверность различий степени изменения показателей до и через 12 месяцев лечения. § ОРИГИНАЛЬНЫЕ СТАТЬИ в 4-й -у 2 человек и после 12 месяцев хронофармакотерапии не определялся.…”

Section: результатыunclassified

“…Однако концентрация лекарственных веществ в перерывах между приемами снижается, что может привести к повышению АД и неблагоприятным исходам [7]. Для решения данной задачи может быть использован хронофармакотерапевтический подход в лечении АГ, который подразумевает оценку изменения фармакокинетики и фармакодинамики препаратов в течение суток, учитывает колебания суточной активности регуляторных систем, тем самым повышая эффективность и безопасность АГТ в целом [8][9][10].…”

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Antihypertensive and vasoprotective effectiveness of the chronopharmacotherapy in patients with arterial hypertension after acute cerebrovascular accident

2019

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Aim. To evaluate the eﬀectiveness of combined antihypertensive chronopharmacotherapy and estimate the daily blood pressure profle (BP) parameters, such as: stiﬀness of the vascular wall and central aortic pressure in patients with arterial hypertension (AH) who underwent transient ischemic atack (TIA) or ischemic stroke (IS).Materials and methods. 235 patients with hypertension who underwent acute cerebrovascular accident were examined. Tere were 116 patients with TIA and 119 with IS. All patients were randomized in 4 groups according to regimen of antihypertensive drugs combination. Te 1st group (n = 59) included patients with AH, who underwent TIA and received indapamide retard 1.5 mg and valsartan 160 mg in the morning regiment of drug therapy. Te 2nd group (n = 57) included patients with AH, who underwent TIA and received indapamide retard 1.5 mg in the morning and valsartan 80 mg twice a day (morning and evening). Te 3rd group (n = 47) included patients with AH, who underwent IS and received indapamide retard 1.5 mg and valsartan at a dose of 160 mg in the morning. Te 4th group (n = 56) included patients with AH, who underwent IS and received indapamide retard 1.5 mg in the morning and valsartan 80 mg twice a day (morning and evening). Ambulatory blood pressure monitoring (ABPM), central aortic pressure (CAP) measurement and vessel wall stiﬀness values were evaluated before treatment and afer 12 months of therapy.Results.Before the start of combined antihypertensive chronopharmacotherapy, most of the parameters for ABPM, vessel wall stiﬀness values and CAP in groups 1 and 2, 3 and 4 were comparable. Achievement of the target level of BP afer 8 weeks of treatment, was signifcantly more ofen in groups with a double sartan therapy (group 2 and group 4) in compare with its single time application only in the morning hours (group 1 and group 3) (p<0.05). Statistically signifcant positive dynamics of the main values of the daily profle of blood pressure, stiﬀness of the vascular wall and central aortic pressure (p <0,05) were registered in all groups. However, more pronounced decline of main parameters of ABPM, stiﬀness of the vascular wall and central aortic pressure values were noted in group with double use sartan therapy in compare with single time sartan therapy in the morning time. (p <0.05). Signifcant positive dynamics of the main values of the ABPM, stiﬀness of the vascular wall and CAP were registered in patients who underwent IS and received double application sartan therapy (4th group) in compare with patients with TIA (2nd group) (p = 0.02).Conclusion.Double use sartan therapy, combined with a thiazide diuretics in patients, who underwent IS or TIA more ofen promotes to get target values of blood pressure, improve the main values of the ABPM, stiﬀness of the vascular wall and CAP in compare with single time sartan therapy in the morning time

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