Comparison of induction chemotherapy plus concurrent chemoradiotherapy and induction chemotherapy plus radiotherapy in locally advanced nasopharyngeal carcinoma

Comparison of TPF and TP Induction Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma Based on TNM Stage and Pretreatment Systemic Immune-Inflammation Index

“…A phase III trial [3] showed that compared with CCRT, IC combined with CCRT could improve overall survival (OS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) in LA-NPC. A recent study [4] showed that IC plus CCRT could increase OS (P < 0.001), PFS (P < 0.001), DMFS (P < 0.001) and LRFS (P < 0.001) in LA-NPC. Similarly, the survival bene ts brought by IC followed by CCRT have been con rmed in many other studies [5].…”

Sequential induction chemotherapy plus intensity‐modulated radiotherapy versus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: the three‐year report of a phase II, single center, randomized, non‐inferiority trial

“…The addition of induction chemotherapy (IC) to CCRT has achieved encouraging outcomes for patients with LA-NPC. [16][17][18][19] Previous studies showed that IC followed by IMRT alone provided comparable efficacy to IC plus CCRT, [20][21][22] as well as CCRT with or without adjuvant chemotherapy (AC). 21,23,24 Moreover, the toxicities of IC plus IMRT are significantly lower.…”

“…21,23,24 Moreover, the toxicities of IC plus IMRT are significantly lower. 20,22,24 Docetaxel plus cisplatin (TP) as an IC regimen for LA-NPC has been shown by a phase 2 study. 25 However, when given two cycles of TP concurrently with IMRT we observed a high incidence of severe toxicities and poor compliance in our practice.…”

Nomogram Predicting the Benefits of Adding Concurrent Chemotherapy to Intensity-Modulated Radiotherapy After Induction Chemotherapy in Stages II–IVb Nasopharyngeal Carcinoma

“…Nasopharyngeal carcinoma (NPC), a malignant head and neck cancer arising from nasopharynx epithelia, is ethnically specific and endemic to southern China, Southeast Asia, North Africa, the Middle East, and Alaska (1)(2)(3). Due to the specific anatomical location and sensitive biological characteristics, radiotherapy (RT) is the backbone of NPC treatment (4). Patients in early tumor stage can be cured by RT alone.…”

“…However, due to the toxicity of CC, a high incidence of grade 3-4 adverse events is often observed, which reduces patients' compliance and lead to the failure of completing subsequent radiotherapy plan (15). Moreover, Wang et al (4). demonstrated that IC+RT and IC+CCRT had similar survival outcomes in stage II-IVb patients, while IC+RT had lower treatment-related grade 3/4 acute hematological toxicity than IC+CCRT group during radiation.…”