Comparison of Individual Tissue-Engineered Bones and Allogeneic Bone in Treating Bone Defects: A Long-Term Follow-Up Study

Peng, Yang; Zhou, Jiangling; Ai, Qiuchi; Yu, Bo; Deng, Min‐Zhi; Luo, Fei; Xie, Zhiyong; Xing, Junchao; Hou, Tianyong

doi:10.1177/0963689720940722

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…Bio-Oss, [ 147,148] Bio-Gide, Bioglass, [ 149] porous titanium granules, [ 150,151] decalcified freeze-dried bone allograft or allogenic demineralized bone matrix, [ 152] allogeneic bone granules, [ 153] Infuse bone graft, [ 154] OP-1 Implant, [ 155] OP-1 Putty, [ 156,157] Osigraft, [ 158,159] etc.…”

Section: Bonementioning

confidence: 99%

Advances in Microgravity Directed Tissue Engineering

Cui¹,

Liu

Zhao

et al. 2023

Adv Healthcare Materials

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Tissue engineering aims to generate functional biological substitutes to repair, sustain, improve, or replace tissue function affected by disease. With the rapid development of space science, the application of simulated microgravity has become an active topic in the field of tissue engineering. There is a growing body of evidence demonstrating that microgravity offers excellent advantages for tissue engineering by modulating cellular morphology, metabolism, secretion, proliferation, and stem cell differentiation. To date, there have been many achievements in constructing bioartificial spheroids, organoids, or tissue analogs with or without scaffolds in vitro under simulated microgravity conditions. Here, the current status, recent advances, challenges, and prospects of microgravity related to tissue engineering are reviewed. Current simulated‐microgravity devices and cutting‐edge advances of microgravity for biomaterials‐dependent or biomaterials‐independent tissue engineering to offer a reference for guiding further exploration of simulated microgravity strategies to produce engineered tissues are summarized and discussed.

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Section: Bonementioning

confidence: 99%

Advances in Microgravity Directed Tissue Engineering

Cui¹,

Liu

Zhao

et al. 2023

Adv Healthcare Materials

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“…The best course of action for treating more severe injuries is to use autologous human donor grafts. Because allogeneic implants are scarce, researchers have conducted experiments to find novel bone tissue engineering methods for bone healing . Because polymer-based scaffolding materials biomimicking the natural extracellular matrix (ECM) could be ideal scaffolds for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…Because allogeneic implants are scarce, researchers have conducted experiments to find novel bone tissue engineering methods for bone healing. 5 Because polymer-based scaffolding materials biomimicking the natural extracellular matrix (ECM) could be ideal scaffolds for bone tissue engineering. the polymeric network to promote bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Aslam Khan,

Aslam,

Bin Abdullah

et al. 2024

ACS Appl. Bio Mater.

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In view of their exceptional approach, excellent inherent biocompatibility and biodegradability properties, and interaction with the local extracellular matrix, protein-based polymers have received attention in bone tissue engineering, which is a multidisciplinary field that repairs and regenerates fractured bones. Bone is a multihierarchical complex structure, and it performs several essential biofunctions, including maintaining mineral balance and structural support and protecting soft organs. Protein-based polymers have gained interest in developing ideal scaffolds as emerging biomaterials for bone fractured healing and regeneration, and it is challenging to design ideal bone substitutes as perfect biomaterials. Several protein-based polymers, including collagen, keratin, gelatin, serum albumin, etc., are potential materials due to their inherent cytocompatibility, controlled biodegradability, high biofunctionalization, and tunable mechanical characteristics. While numerous studies have indicated the encouraging possibilities of proteins in BTE, there are still major challenges concerning their biodegradability, stability in physiological conditions, and continuous release of growth factors and bioactive molecules. Robust scaffolds derived from proteins can be used to replace broken or diseased bone with a biocompatible substitute; proteins, being biopolymers, provide excellent scaffolds for bone tissue engineering. Herein, recent developments in protein polymers for cutting-edge bone tissue engineering are addressed in this review within 3−5 years, with a focus on the significant challenges and future perspectives. The first section discusses the structural fundamentals of bone anatomy and ideal scaffolds, and the second section describes the fabrication techniques of scaffolds. The third section highlights the importance of proteins and their applications in BTE. Hence, the recent development of protein polymers for state-of-the-art bone tissue engineering has been discussed, highlighting the significant challenges and future perspectives.

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“…If the critical defect size is exceeded, the ability of bone to repair and regenerate itself is limited. [6][7][8][9]…”

Section: Introductionmentioning

confidence: 99%

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis

Zhu

Yang

Cheng

et al. 2023

Small

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Mesenchymal stem cells (MSCs) are easily isolated from tissues and have the ability to self-proliferate and to differentiate along different cell lineages, such that they are commonly used in tissue regeneration. [10][11][12][13][14] Several clinical studies have shown that MSCs are safe and effective when used in tissue repair and wound healing. [15][16][17][18][19][20][21] However, despite the therapeutic efficacy of MSCs, there are significant costs and challenges associated with their therapeutic use, because they require strict monitoring of manufacturing, processing, and storage to ensure optimal viability and potency following transplantation. [22,23] Some studies have shown that stem cells transplanted into the body initially undergo significant apoptosis [24][25][26][27][28][29] and that the direct transplantation of apoptotic stem cells can have lasting effects. [30] Apoptosis plays an important role in maintaining physiological homeostasis. [31][32][33] Apoptotic vesicles (apoVs) are extracellular vesicles rich in proteins, RNA, and lipids that are released during apoptosis. [34] Their role is to mediate the transfer of substances and signal exchange between cells and thus maintain homeostasis. In a previous study, we examined the characteristics and specific markers of MSC-derived apoVs and found that proteins on the surface of apoVs regulated platelet aggregation. [35] In another study, we demonstrated the therapeutic effect of MSC-derived apoVs, including in type 2 diabetes, through their interactions with hepatic macrophages. [36] We also found that apoVs activate the Fas pathway in multiple myeloma cells and thus induce apoptosis in these tumor cells. [37] Pluripotent stem cell (PSC)-derived apoVs (PSC-apoVs) can inherit pluripotent molecules from PSCs to stimulate adult stem cells and promote wound healing in mouse skin. [38] Exogenous apoVs (apoEVs) have been reported to promote wound healing and hair growth by activating the Wnt/β-catenin pathway. [39] The administration of apoVs can prevent Th17 differentiation and memory T cell formation to ameliorate inflammation and joint erosion in a mouse model of arthritis. [40] While mouse MSC-derived apoVs has been used to treat osteoporosis, [41] whether apoVs derived from human bone marrow mesenchymal stem cells (hBMMSCs) can impact bone metabolism is unknown. Thus, we investigated the regulatory role of apoVs in bone metabolism and therapeutic effects on bone defects and bone loss. Our results provide an important theoretical basis for novel clinical applications of hBMMSCs-derived apoVs. Mesenchymal stem cells (MSCs) are widely used in the treatment of diseases. After their in vivo application, MSCs undergo apoptosis and release apoptotic vesicles (apoVs). This study investigates the role of apoVs derived from human bone marrow mesenchymal stem cells (hBMMSCs) in bone metabolism and the molecular mechanism of the observed effects. The results show that apoVs can promote osteogenesis and inhibit osteoclast formation in vitro and in vivo. ApoVs may t...

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Comparison of Individual Tissue-Engineered Bones and Allogeneic Bone in Treating Bone Defects: A Long-Term Follow-Up Study

Cited by 5 publications

References 30 publications

Advances in Microgravity Directed Tissue Engineering

Advances in Microgravity Directed Tissue Engineering

Current Perspectives of Protein in Bone Tissue Engineering: Bone Structure, Ideal Scaffolds, Fabrication Techniques, Applications, Scopes, and Future Advances

Apoptotic Vesicles Regulate Bone Metabolism via the miR1324/SNX14/SMAD1/5 Signaling Axis

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