Comparison of indapamide and hydrochlorothiazide plus amiloride as a third drug in the treatment of arterial hypertension

Poulsen, Lene; Friberg, Margrethe; Noer, Ivan; Krusell, Lars Romer; Pedersen, Ole Lederballe

doi:10.1007/bf01883857

Cited by 5 publications

(2 citation statements)

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“…The decrease in potassium attributable to the hydrochlorothiazide + amiloride treatments was non-trivial – equivalent to 0.46 bSD, while mean potassium levels were increased by 0.19 bSD in the atenolol group. The changes in serum potassium in hydrochlorothiazide + amiloride group were in line with findings from previous studies [33, 34]. Potassium-sparing diuretics, despite not fully - are known to correct the fall in serum potassium by increasing serum potassium concentrations [35].…”

Section: Discussionsupporting

confidence: 88%

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Damian

McNamee

Carr

2016

BMC Cardiovasc Disord

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BackgroundTreatment of hypertension reduces incidence of stroke, myocardial infarction and heart failure perhaps partly by controlling different metabolic parameters. There is limited information regarding the changes in potassium, sodium, weight, cholesterol and glucose levels in patients using anti-hypertensives. This study aimed to determine changes in potassium, sodium, glucose, cholesterol, weight, urea and urate levels in patients using anti-hypertensives. Furthermore, to describe these changes and differences between the atenolol, hydrochlorothiazide plus amiloride and placebo arms of the Medical Research Council (MRC) elderly randomised controlled trial.MethodsPatients were randomly allocated to one of the three treatment arms. Measurements were taken at baseline, end of year one and end of year two in 4396 subjects. Linear Mixed Models (LMM) were used to determine the longitudinal profiles of sodium, potassium, weight, cholesterol, glucose, urea and urate. Estimates of changes within groups and difference between groups were obtained.ResultsPatients randomised to receive hydrochlorothiazide + amiloride experienced a significantly greater mean reduction in potassium, sodium and weight compared to placebo at end of year one - mean differences in change −0.18 mmol/L, (95 % CI: −0.21, −0.15); −1.45 mmol/L, (95 % CI: −1.62, −1.29) and −0.46 kgs (95 % CI: −0.73, −0.20) respectively, and greater increases in cholesterol, urea and urate - mean differences in change 0.16 mmol/L, (95 % CI: 0.10,0.22); 0.77 mmol/L, (95 % CI: 0.68, 0.87) and 53.10 μmol/L, (95 % CI: 49.35, 56.85) respectively. Changes were in the same direction but smaller in the atenololarm except for potassium and weight (increases). No group differences in glucose were found.ConclusionResults were in line with expectation except for lack of change in glucose in the hydrochlorothiazide + amiloride arms.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0368-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 88%

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Damian

McNamee

Carr

2016

BMC Cardiovasc Disord

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“…Poulsen et al ve dvojitě zaslepené RCT porovnával indapamid (2,5 mg/den) a HCTZ (25 mg/den) v kombinaci s amiloridem (2,5 mg/den) u 13 hypertoniků. V případě indapamidu byl zaznamenán výraznější pokles kal emie; hyperurikemie byla v obou ramenech studie srovnatelně častá [17].…”

Section: Kombinovaná Léčba Hypertenzeunclassified

The current position of hydrochlorothiazide among thiazide and thiazide-like diuretics

Slíva¹

2018

Vnitr Lek

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Thiazidová a thiazidům podobná diuretika jsou významnou skupinou látek využívaných v léčbě esenciální arteriální hypertenze. Jakkoliv zřejmý je jejich příznivý terapeutický účinek v monoterapii, stále častěji se uplatňují ve fixních kombinacích, ponejvíce s inhibitory ACE nebo sartany. Cílem tohoto článku bylo shrnout především současné postavení hydrochlorothiazidu v léčbě hypertenze a porovnat jeho účinky s ostatními látkami dané skupiny diuretik. Klíčová slova: diuretika -HCTZ -hydrochlorothiazid -hypertenze -chlorthalidon -indapamid -thiazidThe current position of hydrochlorothiazide among thiazide and thiazide-like diuretics Summary Thiazide and thiazide-like diuretics are an important group of drugs used in the treatment of essential arterial hyper tension. While their beneficial therapeutic effect in monotherapy is evident, they are increasingly used in fixed combinations, particularly with ACE inhibitors or sartans. The aim of this article was to summarize the current status of hydrochlorothiazide and compare its effects with other substances in this subgroup of diuretics.

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Indapamide

2016

Meyler's Side Effects of Drugs

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Comparison of indapamide and hydrochlorothiazide plus amiloride as a third drug in the treatment of arterial hypertension

Cited by 5 publications

References 9 publications

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

Changes in selected metabolic parameters in patients over 65 receiving hydrochlorothiazide plus amiloride, atenolol or placebo in the MRC elderly trial

The current position of hydrochlorothiazide among thiazide and thiazide-like diuretics

Indapamide

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