Comparison of incidence of insulin-dependent diabetes mellitus in children and young adults in the Province of Turin, Italy, 1984-91

Abstract

To document the incidence of IDDM in the Province of Turin (Italy) in the 8‐year period 1984–91 in children (0–14 years) and young adults (15–29 years), in relation to age, sex, monthly‐seasonal variability, calendar year and urban/rural area, (all newly diagnosed cases (502) were ascertained through primary and secondary data sources and completeness of ascertainment estimated with the two sample capture–recapture method (99 % in childhood and 95 % in young adults). The independent effect of age, sex, calendar year, and urban/rural area was estimated with a Poisson regression model. Age‐specific incidence rates were 8.42/100000 (95 % CI 7.37–9.62) and 6.72/100000 (95 % CI 5.96–7.58), respectively, in the age groups 0–14 and 15–29 years. Sex differences were evident in young adults, with an almost 1.5‐fold increased risk in men (8.37/100000, 95 % CI 7.21–9.71 vs 5.00/100000, CI 4.09–6.10). Seasonal trend was evident in childhood. Predictors of incidence rates were age, place of residence and interaction between sex and age; no temporal trend was detected. No significant differences were found in the two age‐groups with respect to glycaemia, glycosuria, ketonuria, and fasting C‐peptide levels. In conclusion, this study shows sex differences in IDDM risk in young adults; 55 % of incident cases occurring in young adults; an independent contribution of urban/rural differences to IDDM risk; no temporal trend in 1984–91; a seasonal pattern of incidence in children; no significant differences in clinical presentation between age groups. © 1997 John Wiley & Sons, Ltd.

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