Comparison of in vivo bioactivity and compressive strength of a novel superporous hydroxyapatite with beta-tricalcium phosphates

Okanoue, Yusuke; Ikeuchi, Masahiko; Takemasa, Ryuichi; Tani, Tohru; Matsumoto, Takuya; Sakamoto, Michiko; Nakasu, Masanori

doi:10.1007/s00402-012-1578-4

Cited by 22 publications

(14 citation statements)

References 30 publications

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“…Okanoue et al . reported that resorption of β-TCP granules was not necessarily accompanied by bone ingrowth in a rabbit bone defect model [13]. Generally, rodents have higher bone metabolic activity than other mammals, which can induce rapid granule degradation and new bone formation [17].…”

Section: Discussionmentioning

confidence: 99%

Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model

Choi

Liu

Honnami

et al. 2014

The Journal of Veterinary Medical Science

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We investigated biodegradability and new bone formation after implantation of tetrapod-shaped granular artificial bone (Tetrabone®) or β-tricalcium phosphate granules (β-TCP) in experimental critical-size defects in dogs, which were created through medial and lateral femoral condyles. The defect was packed with Tetrabone® (Tetrabone group) or β-TCP (β-TCP group) or received no implant (control group). Computed tomography (CT) was performed at 0, 4 and 8 weeks after implantation. Micro-CT and histological analysis were conducted to measure the non-osseous tissue rate and the area and distribution of new bone tissue in the defect at 8 weeks after implantation. On CT, β-TCP was gradually resorbed, while Tetrabone® showed minimal resorption at 8 weeks after implantation. On micro-CT, non-osseous tissue rate of the control group was significantly higher compared with the β-TCP and Tetrabone groups (P<0.01), and that of the β-TCP group was significantly higher compared with the Tetrabone group (P<0.05). On histology, area of new bone tissue of the β-TCP group was significantly greater than those of the Tetrabone and control groups (P<0.05), and new bone distribution of the Tetrabone group was significantly greater than those of the β-TCP and control groups (P<0.05). These results indicate differences in biodegradability and connectivity of intergranule pore structure between study samples. In conclusion, Tetrabone® may be superior for the repair of large bone defects in dogs.

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Section: Discussionmentioning

confidence: 99%

Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model

Choi

Liu

Honnami

et al. 2014

The Journal of Veterinary Medical Science

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“…Briefly, when compared to both α- and β-TCP, HA is a more stable phase under the physiological conditions, as it has a lower solubility (Table 1) and, thus, a slower resorption kinetics [137,138,139,140]. Therefore, the BCP concept is determined by the optimum balance of a more stable phase of HA and a more soluble TCP.…”

Section: Bioceramics Of Calcium Orthophosphatesmentioning

confidence: 99%

“…Thus, porous calcium orthophosphate implants cannot be loaded and are used to fill only small bone defects. However, their strength increases gradually when bones ingrow into the porous network of calcium orthophosphate implants [139,585,586,587,588]. For example, Martin et al reported bending strengths of 40–60 MPa for a porous HA implant filled with 50%–60% of cortical bone [585], while in another study an ingrown bone increased strength of porous HA bioceramics by a factor of 3 to 4 [587].…”

Section: The Major Propertiesmentioning

confidence: 99%

Calcium Orthophosphate-Based Bioceramics

Dorozhkin¹

2013

Materials

228

153

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Various types of grafts have been traditionally used to restore damaged bones. In the late 1960s, a strong interest was raised in studying ceramics as potential bone grafts due to their biomechanical properties. A bit later, such synthetic biomaterials were called bioceramics. In principle, bioceramics can be prepared from diverse materials but this review is limited to calcium orthophosphate-based formulations only, which possess the specific advantages due to the chemical similarity to mammalian bones and teeth. During the past 40 years, there have been a number of important achievements in this field. Namely, after the initial development of bioceramics that was just tolerated in the physiological environment, an emphasis was shifted towards the formulations able to form direct chemical bonds with the adjacent bones. Afterwards, by the structural and compositional controls, it became possible to choose whether the calcium orthophosphate-based implants remain biologically stable once incorporated into the skeletal structure or whether they were resorbed over time. At the turn of the millennium, a new concept of regenerative bioceramics was developed and such formulations became an integrated part of the tissue engineering approach. Now calcium orthophosphate scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous and harbor different biomolecules and/or cells. Therefore, current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery. Perspective future applications comprise drug delivery and tissue engineering purposes because calcium orthophosphates appear to be promising carriers of growth factors, bioactive peptides and various types of cells.

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“…Hydroxyapatite (HAP), the chemically pure version of the mineral component of bone, however, is typified by impractically low resorption rates [1–3]. Reduction of the particle size [4], an increase in porosity [5] and introduction of ionic substitutions, such as magnesium [6], sodium [7], fluorine [8] and/or carbonate [9], so as to mimic the composition and microstructure of biological apatite, have presented approaches to resolving this issue, though with limited success. Namely, even the least sparingly soluble calcium-deficient apatites usually resorb slower than the new bone tissue formation rate [10], whereas HAP with high porosity is weak even to compression and not suitable for load-bearing applications [11].…”

Section: Introductionmentioning

confidence: 99%

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

Uskoković

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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BACKGROUND Does chemistry govern biology or it is the other way around - that is a broad connotation of the question that this study attempted to answer. METHOD Comparison was made between the solubility and osteoclastic resorbability of four fundamentally different monophasic CP powders with monodisperse particle size distributions: alkaline hydroxyapatite (HAP), acidic monetite (DCP), β-calcium pyrophosphate (CPP), and amorphous CP (ACP). RESULTS With the exception of CPP, the difference in solubility between different calcium phosphate (CP) phases became neither mitigated nor reversed, but augmented in the resorptive osteoclastic milieu. Thus, DCP, a phase with the highest solubility, was also resorbed more intensely than any other CP phase, whereas HAP, a phase with the lowest solubility, was resorbed least. CPP becomes retained inside the cells for the longest period of time, indicating hindered digestion of only this particular type of CP. Osteoclastogenesis was mildly hindered in the presence of HAP, ACP and DCP, but not in the presence of CPP. The most viable CP powder with respect to the mitochondrial succinic dehydrogenase activity was the one present in natural biological bone tissues: HAP. CONCLUSION Chemistry in this case does have a direct effect on biology. Biology neither overrides nor reverses the chemical propensities of inorganics with which it interacts, but rather augments and takes a direct advantage of them. SIGNIFICANCE These findings set the fundamental basis for designing the chemical makeup of CP and other biosoluble components of tissue engineering constructs for their most optimal resorption and tissue regeneration response.

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Comparison of in vivo bioactivity and compressive strength of a novel superporous hydroxyapatite with beta-tricalcium phosphates

Abstract: These findings should be kept in mind when choosing the highly porous ceramics.

Cited by 22 publications

References 30 publications

Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model

Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model

Calcium Orthophosphate-Based Bioceramics

Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro ?

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