Comparison of in vitro Surface Properties of Clove Oil–Phospholipid Suspensions with those of ALEC, Exosurf and Survanta

Banerjee, Rinti; Bellare, Jayesh

doi:10.1006/pupt.2000.0271

Pulmonary Pharmacology & Therapeutics

2001

DOI: 10.1006/pupt.2000.0271

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Comparison of in vitro Surface Properties of Clove Oil–Phospholipid Suspensions with those of ALEC, Exosurf and Survanta

Rinti Banerjee

Jayesh Bellare

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Cited by 5 publications

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“…The essential oil is also used as an anesthetic and analgesic, in addition to many other uses (Chaieb et al, 2007;Tyler et al, 1988;Zheng et al, 1992). In general, these activities were related to eugenol, which is one of the most abundant compounds present in essential oil extracted mainly from the floral buttons of the plant (Banerjee & Bellare, 2001;Fyfe et al, 1998). Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) is widely used in clinical dentistry, as sealers for root canals, and induces a high cytotoxicity in cells (Abraham, 2001;Huang et al, 2001;Rompelberg et al, 1996;Tai et al, 2002).…”

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confidence: 99%

Genotoxicity Induced byEugenia CaryophyllataInfusion

Santos

Egito

Medeiros

et al. 2008

Journal of Toxicology and Environmental Health, Part A

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Several therapeutic properties have been described for Eugenia caryophyllata (clove). In the present study the infusion of E. caryophyllata was evaluated in a series of bacterial and cell-free assays in order to determine genotoxic potential. Negative results were obtained in the SOS chromotest and in the Salmonella reversion assay using strains TA97a, TA98, TA100, and TA102. However, in a forward mutagenesis assay an increase in mutagenesis and high cytotoxicity was observed with the CC104 mutMmutY strain, suggesting that oxidative DNA damage occurred. The treatment of plasmid with clove infusion showed that DNA strand breaks and sites recognized by formamidopyrimidine-DNA-glycosylase (FPG/MutM) were generated. Data suggest that the occurrence of oxidative DNA damage, with low mutagenic potential, may also be involved in the cytotoxicity attributed to clove infusion.

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mentioning

confidence: 99%

Genotoxicity Induced byEugenia CaryophyllataInfusion

Santos

Egito

Medeiros

et al. 2008

Journal of Toxicology and Environmental Health, Part A

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Herbal Antitussives

Ziment¹

2002

Pulmonary Pharmacology & Therapeutics

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The mechanisms of actions of cough medicines are not always known. The problem is exacerbated for herbal medicines, where the effectiveness of the plant or its phytochemicals have rarely been carefully evaluated. Moreover, the most active phytomedicinal constituent is difficult to identify, and the expense and difficulty of such studies discourages sponsors who may not be able to benefit by subsequent exclusive marketing of the herbal remedy. Most popular herbs used as cough medicines appear to be demulcents whose action is confined to the oropharynx. It is probable that the vast majority of allegedly effective herbal cough medicines act as non-specific emetic-expectorants. The proof of activity of even marketed herbal derivatives such as guaifenesin and codeine is difficult to obtain. It is therefore likely that herbal cough medications will never be shown to be more active than placebos. Nevertheless, these plant products will continue to be popular remedies for patients and their health care advisors.

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Effect of Fluidizing Agents on Paclitaxel Penetration in Cervical Cancerous Monolayer Membranes

2007

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The aim of this study was to compare modulation of paclitaxel penetration in cancerous and normal cervical monolayers by four fluidizing agents: PCPG (9:1 DPPC:PG), PCPE (9:1 DPPC:DOPE), ALEC (7:3 DPPC:PG) and Exosurf (13.5:1.5:1.0 DPPC:hexadecanol:tyloxapol). Presence of the fluidizing agents improved drug penetration significantly. PCPG and PCPE were promising penetration enhancers. PCPG 0.1% caused 3.8- and 1.7-fold higher maximum increments in surface pressure due to drug penetration, (Delta pi)(max), than the control in cancerous and normal monolayers, respectively, at 20 mN/m. In cancerous monolayer at 20 mN/m, presence of 0.1%, 0.5%, 1%, 5% and 10% PCPE produced 3.4-, 5.7-, 7.4-, 9.6- and 9.8-fold higher drug penetration compared to the control monolayer without PCPE, respectively. In cancerous monolayer at 20 mN/m, PCPG and PCPE liposomes having 1 mg lipid gave 2.1 and 3.6 times higher (Delta pi)(max )compared to the control, respectively. Further, the liposomal drug penetration was found to be directly proportional to the liposomal lipid content. The effect of the fluidizing agents was confirmed by increased calcein release from model cervical cancer liposomes. These results may have implications in using the above biocompatible lipids and surfactants as penetration enhancers along with anticancer drugs or as carriers for liposomal formulations of anticancer drugs for improved membrane penetration.

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Comparison of in vitro Surface Properties of Clove Oil–Phospholipid Suspensions with those of ALEC, Exosurf and Survanta

Cited by 5 publications

References 24 publications

Genotoxicity Induced byEugenia CaryophyllataInfusion

Genotoxicity Induced byEugenia CaryophyllataInfusion

Herbal Antitussives

Effect of Fluidizing Agents on Paclitaxel Penetration in Cervical Cancerous Monolayer Membranes

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