Comparison of in Vitro Potency of Corticosteroids with Ability to Raise Intraocular Pressure

Cantrill, Herbert L.; Palmberg, Paul; Zink, Harry A.; Waltman, Stephen R.; Podos, Steven M.; Becker, Bernard

doi:10.1016/0002-9394(75)90687-x

Cited by 105 publications

(50 citation statements)

References 18 publications

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“…This corresponds to the timing of steroidinduced pressure rise, which can occur as early as week 2, although typically it occurs at week 4. 10 Topical steroids have been shown to produce a pressure response over a period of weeks in both normal 11,16 and glaucomatous eyes 17,18 although patients with glaucoma are much more susceptible to steroid-induced pressure rise. 10 Our study supports the hypothesis that steroids are at least partially responsible for this HP after AGV surgery.…”

Section: Discussionmentioning

confidence: 99%

Corticosteroids Versus NSAIDs on Intraocular Pressure and the Hypertensive Phase After Ahmed Glaucoma Valve Surgery

Yuen

Buys

Jin

et al. 2011

Journal of Glaucoma

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Section: Discussionmentioning

confidence: 99%

Corticosteroids Versus NSAIDs on Intraocular Pressure and the Hypertensive Phase After Ahmed Glaucoma Valve Surgery

Yuen

Buys

Jin

et al. 2011

Journal of Glaucoma

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“…Topical steroids have been shown to produce a steroid response over a period of weeks in both normal 7 and glaucomatous eyes 8,27 and Armaly showed this with provocation testing administering dexamethasone eye drops three times a day to the right eye for 4 weeks, using the left eye as a control. 7,8 Weinreb et al 29 have reported that, although rare, a more acute onset rise can occur within hours of starting intensive topical dexamethasone.…”

Section: Timing Of Responsementioning

confidence: 99%

“…Alternative corticosteroid formulations Topical treatments can be changed to preparations such as fluoromethalone 0.1% or rimexolone 1%, which are claimed to have less effect on IOP, 27 or in certain situations to nonsteroidal anti-inflammatory drugs (NSAIDs). For patients prescribed systemic corticosteroids, introducing or increasing steroid-sparing agents such as cyclophosphamide or methotrexate may allow the corticosteroid dosage to be reduced.…”

Section: Poagmentioning

confidence: 99%

Corticosteroid-induced glaucoma: a review of the literature

Kersey

Broadway

2005

Eye

375

228

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The intraocular pressure rise that can complicate the use of topical or systemic corticosteroid has been recognised for 50 years. More recently, following isolation of the myocilin gene (previously known as the trabecular meshwork inducible glucocorticoid response or TIGR gene), there has been renewed interest in this steroid-responsive phenomenon. Furthermore, the currently fashionable use of injectable intraocular steroids in the management of clinically significant subretinal fluid and macular oedema has resulted in an increased incidence. Animal studies, cell biology, molecular biology, and an improved knowledge of genetics have provided a better understanding of the mechanisms behind the response. The purpose of this review is to describe the risk factors for developing corticosteroid-induced glaucoma, to discuss the underlying mechanisms and genetics of the condition and to present management options.

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“…Grades von Patienten mit POWG " junges oder höheres Lebensalter " Bindegewebserkrankungen " Art des Steroids " Applikationsform " Applikationsdauer Tab. 2 Ungefähre IOD-steigernde Wirkung unterschiedlicher Steroide bei Steroidrespondern nach topischer Applikation [15,16]. einem Anstieg des IOD.…”

Section: Art Der Applikationunclassified

Klinik und Therapie des Steroidglaukoms

Rüfer¹,

Uthoff²

2013

Klin Monatsbl Augenheilkd

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In steroid responders, topical or systemic application of steroids leads to extracellular deposits in the trabecular meshwork which increase trabecular meshwork outflow resistance. 30-40 % of the normal population are steroid responders. About 5 % develop an intraocular pressure (IOP) rise of > 15 mmHg. These patients are termed "high responders". In patients with primary open angle glaucoma (POAG), the proportion of steroid responders sums up to 90 %. The extent of steroid response depends on the kind of steroid used and on the duration of its administration. Dexamethasone has the highest IOP increasing potency. Differential diagnoses are POAG, ocular hypertension, normal tension glaucoma, pseudoexfoliation glaucoma and secondary glaucoma due to different reasons. To make the diagnosis, a detailed anamnesis is crucial. A recompensated IOP after the end of steroid use proves the diagnosis. The treatment of steroid glaucoma includes topical antiglaucoma medications, glaucoma filtration surgery, trabeculotomy, and laser surgery. So far, only few comparative studies on different treatment options have been published on steroid glaucoma. In some cases of therapy-resistant IOP increases following intravitreal or subconjunctival steroid administration, operative removal of the steroids can be considered. A gene therapy treatment of steroid glaucoma is still a topic of research.

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Comparison of in Vitro Potency of Corticosteroids with Ability to Raise Intraocular Pressure

Cited by 105 publications

References 18 publications

Corticosteroids Versus NSAIDs on Intraocular Pressure and the Hypertensive Phase After Ahmed Glaucoma Valve Surgery

Corticosteroids Versus NSAIDs on Intraocular Pressure and the Hypertensive Phase After Ahmed Glaucoma Valve Surgery

Corticosteroid-induced glaucoma: a review of the literature

Klinik und Therapie des Steroidglaukoms

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