Comparison of in vitro hydrolysis, subcutaneous and intramedullary implantation to evaluate the strength retention of absorbable osteosynthesis implants

Vasenius, Jarkko; Vainionpää, S.; Vihtonen, Kimmo; Mäkelä, Antero; Rokkanen, P; Mero, M.; Törmälä, Pertti

doi:10.1016/0142-9612(90)90065-x

Cited by 44 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, PDLLA and PLGA are believed to be absorbed completely in vitro in two to three and one to two years, respectively [30]. Furthermore, PDLLA and PLGA are known to degrade faster in vivo in vascularized cancellous bone and subcutaneous tissue than in vitro [29]. Hasegawa et al [17] reported that a hydroxyapatite/PDLLA composite was resorbed completely and cancellous bone formation plateaued at 26 weeks in vivo.…”

Section: Discussionmentioning

confidence: 97%

Glenoid rim fracture through anchor points after arthroscopic Bankart repair for shoulder instability

Park¹,

Lee

Oh³

et al. 2014

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Glenoid rim fracture through anchor points after arthroscopic Bankart repair for shoulder instability

Park¹,

Lee

Oh³

et al. 2014

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

show abstract

“…1,22 Previously, some investigators have observed enhanced strength loss of PLA in vivo compared to in vitro, probably due to enzymatic action. 23 Some have reported no differences between rates of degradation of PLDLA 96/4 in vivo and in vitro. 5 Other studies have shown that hydroxyl free radicals ( .…”

Section: Discussionmentioning

confidence: 99%

Comparison of strength properties of poly-L/D-lactide (PLDLA) 96/4 and polyglyconate (Maxon�) sutures:In vitro, in the subcutis, and in the achilles tendon of rabbits

Kangas

Paasimaa

Mäkelä

et al. 2001

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Achilles tendon rupture is a common injury. Absorbable sutures are not commonly used because of their limited strength properties. Recently, sutures with prolonged strength retention properties have been developed. The aim of the study is to test the mechanical properties of recently developed poly-L/D-lactide (PLDLA) sutures in comparison with polyglyconate (Maxon) sutures. PLDLA (0.2 mm thick) and Maxon (4.0) sutures were studied in vitro by immersion in a buffered saline solution (pH 7.4). Tensile strength tests were done on sutures retrieved after 1-26 weeks. In vivo, they were implanted in the subcutis of 32 rabbits. Tensile strength tests were done on sutures retrieved after 1-6 weeks. The sutures were also used to repair the Achilles tendon in rabbits. Maximum force before breaking and percentage elongation of tendons were determined. Although PLDLA had a lower initial tensile strength than Maxon, PLDLA showed more prolonged tensile strength retention than Maxon. Tendons repaired with PLDLA, however, had a lower strength than Maxon-repaired tendons at six weeks (insignificant difference). PLDLA has more prolonged tensile strength properties compared with Maxon. Thus, PLDLA offers an alternative to Maxon in repair of the Achilles tendon.

show abstract

“…Attempts to do this, however, have not been successful due to rapid strength and modulus loss of the composite material following exposure to simulated body fluids. [7][8][9][10][11][12][13] This behavior has been attributed to rapid fiber/polymer interfacial bond hydrolysis following exposure to an aqueous environment.…”

Section: Introductionmentioning

confidence: 99%

Real‐time dissolution measurement of sized and unsized calcium phosphate glass fibers

Rinehart

Taylor

Tian

et al. 1999

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

The objective of this study was to develop an efficient "real time" measurement system able to directly measure, with microgram resolution, the dissolution rate of absorbable glass fibers, and utilize the system to evaluate the effectiveness of silane-based sizing as a means to delay the fiber dissolution process. The absorbable glass fiber used was calcium phosphate (CaP), with tetramethoxysilane selected as the sizing agent. E-glass fiber was used as a relatively nondegrading control. Both the unsized-CaP and sized-CaP degraded linearly at both the 37 degrees C and 60 degrees C test temperature levels used. No significant decrease in weight-loss rate was recorded when the CaP fiber tows were pretreated, using conventional application methods, with the tetramethoxysilane sizing for either temperature condition. The unsized-CaP and sized-CaP weight loss rates were each significantly higher at 60 than at 37 degrees C (both p < 0.02), as expected from dissolution kinetics. In terms of actual weight loss rate measured using our system for phosphate glass fiber, the unsized-CaP fiber we studied dissolved at a rate of 10.90 x 10(-09) and 41.20 x 10(-09) g/min-cm(2) at 37 degrees C and 60 degrees C, respectively. Considering performance validation of the developed system, the slope of the weight loss vs. time plot for the tested E-glass fiber was not significantly different compared to a slope equal to zero for both test temperatures.

show abstract

Comparison of in vitro hydrolysis, subcutaneous and intramedullary implantation to evaluate the strength retention of absorbable osteosynthesis implants

Cited by 44 publications

References 6 publications

Glenoid rim fracture through anchor points after arthroscopic Bankart repair for shoulder instability

Glenoid rim fracture through anchor points after arthroscopic Bankart repair for shoulder instability

Comparison of strength properties of poly-L/D-lactide (PLDLA) 96/4 and polyglyconate (Maxon�) sutures:In vitro, in the subcutis, and in the achilles tendon of rabbits

Real‐time dissolution measurement of sized and unsized calcium phosphate glass fibers

Contact Info

Product

Resources

About