Comparison of in-phase and opposed-phase T1W gradient echo and T2W fast spin echo dixon chemical shift imaging for the assessment of non-neoplastic, benign neoplastic and malignant marrow lesions

Saifuddin, Asif; Shafiq, Hassan; Malhotra, Karan; Santiago, Rodney; Pressney, Ian

doi:10.1007/s00256-020-03663-x

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…These can be explained by the fact that benign lesions included in this study are lesions with residual bone marrow fat. The results showed that the sequence used in this study can differentiate marrow-replacing malignant lesions from marrow non-replacing variable benign lesions, including nodular hematopoietic marrows, which are sometimes difficult to distinguish from metastases [16] , [17] , [18] .…”

Section: Discussionmentioning

confidence: 81%

Quantitative biomarkers for distinguishing bone metastasis and benign bone marrow lesions using turbo spin echo T1- and T2-weighted Dixon imaging at 3.0 T

Ogiwara,

Fukuda,

Yonenaga

et al. 2023

European Journal of Radiology Open

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Section: Discussionmentioning

confidence: 81%

Quantitative biomarkers for distinguishing bone metastasis and benign bone marrow lesions using turbo spin echo T1- and T2-weighted Dixon imaging at 3.0 T

Ogiwara,

Fukuda,

Yonenaga

et al. 2023

European Journal of Radiology Open

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“…Furthermore, we showed that the same FSE T2w Dixon sequence provided high diagnostic performance in the differentiation of benign and malignant VCFs through quantitative analysis. While very few reports of quantitative analysis of spin echo-based Dixon sequences exist for the characterization of bone marrow lesions, quantitative chemical shift imaging has been previously validated with gradient echo-based sequences, including for the characterization of VCFs [22,23]. In a meta-analysis, Thawait et al found one study showing a sensitivity and specificity of 95% (95% CI: 81, 99) and 89% (95% CI: 81, 93), respectively, with a malignancy threshold of signal drop < 20% [2].…”

Section: Discussionmentioning

confidence: 99%

Differentiation between benign and malignant vertebral compression fractures using qualitative and quantitative analysis of a single fast spin echo T2-weighted Dixon sequence

et al. 2021

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Objectives To determine and compare the qualitative and quantitative diagnostic performance of a single sagittal fast spin echo (FSE) T2-weighted Dixon sequence in differentiating benign and malignant vertebral compression fractures (VCF), using multiple readers and different quantitative methods. Methods From July 2014 to June 2020, 95 consecutive patients with spine MRI performed prior to cementoplasty for acute VCFs were retrospectively included. VCFs were categorized as benign (n = 63, mean age = 76 ± 12 years) or malignant (n = 32, mean age = 63 ± 12 years) with a best valuable comparator as a reference. Qualitative analysis was independently performed by four radiologists by categorizing each VCF as either benign or malignant using only the image sets provided by FSE T2-weighted Dixon sequences. Quantitative analysis was performed using two different regions of interest (ROI1-2) and three methods (signal drop, fat fraction (FF) from ROIs, FF maps). Diagnostic performance was compared using ROC curves analyses. Interobserver agreement was assessed using kappa statistics and intraclass correlation coefficients (ICC). Results The qualitative diagnostic performance ranged from area under the curve (AUC) = 0.97 (95% CI: 0.91–1.00) to AUC = 0.99 (95% CI: 0.95–1.0). The quantitative diagnostic performance ranged from AUC = 0.82 (95% CI: 0.73–0.89) to AUC = 0.97 (95% CI: 0.91–0.99). Pairwise comparisons showed no statistical difference in diagnostic performance (all p > 0.0013, Bonferroni-corrected p < 0.0011). All five cases with disagreement among the readers were correctly diagnosed at quantitative analysis using ROI2. Interobserver agreement was excellent for both qualitative and quantitative analyses. Conclusions A single FSE T2-weighted Dixon sequence can be used to differentiate benign and malignant VCF with high diagnostic performance using both qualitative and quantitative analyses, which can provide complementary information. Key Points • Qualitative analysis of a single FSE T2-weighted Dixon sequence yields high diagnostic performance and excellent observer agreement for differentiating benign and malignant compression fractures. • The same FSE T2-weighted Dixon sequence allows quantitative assessment with high diagnostic performance. • Quantitative data can readily be extracted from the FSE T2-weighted Dixon sequence and may provide complementary information to the qualitative analysis, which may be useful in doubtful cases.

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“…The Dixon technique uses CSI to combat this, able to quantify the amount of fat within a lesion by highlighting the degree of SI drop between IP and OP images. 19 It is generally accepted that a SI drop > 20% at 1.5 T is a reliable cut-off value indicating microscopic fat content, and therefore excluding marrow replacement by a neoplastic process (►Fig. 6).…”

Section: Focal Nodular Marrow Hyperplasiamentioning

confidence: 99%

“…The Dixon sequence, particularly the T2W FSE Dixon sequence that is less susceptible to the presence of medullary sclerosis, should be considered to investigate these cases further, often saving the patient an unnecessary needle biopsy. 19 The described appearances on standard TSE sequences, CSI, and CT (if required) should be sufficient to make a confident imaging diagnosis and avoid unnecessary biopsy. However, in the setting of underlying malignancy, a repeat MRI after 6 months can be performed to confirm a lack of progression or even partial/complete resolution, further supporting FNMH.…”

Section: Focal Nodular Marrow Hyperplasiamentioning

confidence: 99%

Normal Bone Marrow and Non-neoplastic Systemic Hematopoietic Disorders in the Adult

Tyler

Rajakulasingam

Saifuddin

2023

Semin Musculoskelet Radiol

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This article provides an overview of the imaging appearances of normal adult bone marrow with an emphasis on magnetic resonance imaging. We also review the cellular processes and imaging features of normal developmental yellow-to-red marrow conversion and compensatory physiologic or pathologic red marrow reconversion. Key imaging features that differentiate between normal adult marrow, normal variants, non-neoplastic hematopoietic disorders, and malignant marrow disease are discussed, as well as posttreatment changes.

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Comparison of in-phase and opposed-phase T1W gradient echo and T2W fast spin echo dixon chemical shift imaging for the assessment of non-neoplastic, benign neoplastic and malignant marrow lesions

Cited by 11 publications

References 17 publications

Quantitative biomarkers for distinguishing bone metastasis and benign bone marrow lesions using turbo spin echo T1- and T2-weighted Dixon imaging at 3.0 T

Quantitative biomarkers for distinguishing bone metastasis and benign bone marrow lesions using turbo spin echo T1- and T2-weighted Dixon imaging at 3.0 T

Differentiation between benign and malignant vertebral compression fractures using qualitative and quantitative analysis of a single fast spin echo T2-weighted Dixon sequence

Normal Bone Marrow and Non-neoplastic Systemic Hematopoietic Disorders in the Adult

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