Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells

Ji, Lujun; Bao, Liuliu; Gu, Zhifeng; Zhou, Qiao; Lv, Yi; Zheng, Ya; Xu, Yingbin; Zhang, Xiang; Feng, Xingmei

doi:10.1007/s12026-019-09088-6

Cited by 72 publications

(85 citation statements)

References 44 publications

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“…An in vitro study revealed that DPSCs-derived exosomes (DPSCs-Exos) inhibited the differentiation of CD4 + T cells into T helper 17 cells (Th17) and reduced the secretion of the pro-inflammatory factors IL-17 and TNF-α. [38] DPSCs-Exos effectively promoted the polarization of CD4 + T cells into Treg cells and increased the release of the anti-inflammatory factors IL-10 and TGF-β. [38] These capabilities of DPSCs-Exos were stronger than BMSCs-Exos, except in the inhibition of the proliferation of the CD4 + T cells, which suggests DPSCs-Exos as a new therapeutic tool for the treatment of immunological diseases.…”

Section: Immunomodulatory Effectsmentioning

confidence: 98%

“…[38] DPSCs-Exos effectively promoted the polarization of CD4 + T cells into Treg cells and increased the release of the anti-inflammatory factors IL-10 and TGF-β. [38] These capabilities of DPSCs-Exos were stronger than BMSCs-Exos, except in the inhibition of the proliferation of the CD4 + T cells, which suggests DPSCs-Exos as a new therapeutic tool for the treatment of immunological diseases. MiR-100-5p was enriched in exosomes derived from SHEDs and suppressed the temporomandibular joint (TMJ) chondrocyte expression of interleukin-6 (IL-6), IL-8, matrix metalloproteinase 1 (MMP1), MMP3, MMP9, MMP13, disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) [39].…”

Section: Immunomodulatory Effectsmentioning

confidence: 98%

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Exosomes from oral tissue stem cells: biological effects and applications

et al. 2020

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As natural nanoparticles, exosomes are a type of extracellular vesicles that are enclosed by a lipid bilayer and contain various cargos, including miRNA, mRNA, DNA and proteins. Exosomes have rapidly gained attention as a highly promising cell-free therapy. Because the cargo of exosomes changes with the changes in parent cells and status, exosomes from different types of cells may exhibit different biological effects. Considering the particularity of oral tissue stem cells, their exosomes were isolated and used to examine their related biological functions and the possibility of replacing stem cells. A variety of exosomes of oral tissue stem cells were studied, and the results revealed many special biological characteristics of these exosomes and their parent cells, especially immunomodulation, osteogenesis, odontogenesis, neuroprotection, nerve regeneration, wound healing, skin regeneration and vascularization. The oral tissue stem cell exosomes may be loaded with drugs or genes and act as tools for tumor treatment. The relevant results showed that exosomes from oral tissue stem cells were potent therapeutic tools. The present review focuses on the biological function and application of oral tissue stem cell-derived exosomes.

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Section: Immunomodulatory Effectsmentioning

confidence: 98%

Section: Immunomodulatory Effectsmentioning

confidence: 98%

Exosomes from oral tissue stem cells: biological effects and applications

et al. 2020

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“…EVs regulate dendritic cell functions with impairment of antigen uptake by immature cells and reductions in cell maturation and activation [46]. Although there are differences depending on the parent cells, MSC EVs may inhibit the proliferation of CD4 + and CD8 + T cells and the promotion of apoptosis in CD4 + T cells [47,48]. EVs may also promote the conversion of T helper type 1 (Th1) into T helper type 2 (Th2) cells whereas differentiation into Th17 cells was decreased [44].…”

Section: Immune Regulation and Rheumatoid Arthritismentioning

confidence: 99%

“…EVs may also promote the conversion of T helper type 1 (Th1) into T helper type 2 (Th2) cells whereas differentiation into Th17 cells was decreased [44]. In addition, EVs polarize activated CD4 + T cells to CD4 + CD25 + FOXP3 + regulatory T cells (Tregs) which requires activation of T cells by antigen presenting cells [47,49,50]. As MSC EVs polarize immune cells toward an immunosuppressive phenotype only in the presence of an activated immune system [50], homeostatic immune activity would not be affected by EVs treatment thus avoiding the increased risk of infection or cancer observed with immunosuppressive drugs [51].…”

Section: Immune Regulation and Rheumatoid Arthritismentioning

confidence: 99%

Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases

Alcaraz

Compañ

Guillén

2019

Cells

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Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC effects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair. In this review, we summarize the current understanding of MSC EVs actions in preclinical studies of (1) immune regulation and rheumatoid arthritis, (2) bone repair and bone diseases, (3) cartilage repair and osteoarthritis, (4) intervertebral disk degeneration and (5) skeletal muscle and tendon repair. We also discuss the mechanisms underlying these actions and the perspectives of MSC EVs-based strategies for future treatments of musculoskeletal disorders.

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“…This characteristic of DPSC-derived exosomes can play a significant role in cell-free therapy for various autoimmune diseases. [ 12 ]…”

Section: T Herapeutic a Pplications Of mentioning

confidence: 99%

Exosomes in the oral and maxillofacial region

Lakshmi¹,

Nallusamy

Manivasagam

et al. 2020

J Pharm Bioall Sci

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A BSTRACT Exosomes are a type of extracellular vesicles, released from different tissues in a living individual. By virtue of their ability to be released from both the normal and diseased individual, they play an inevitable role in the diagnosis, prognosis, and therapeutic aspect of a disease. With this background, the untapped role of exosomes in the field of oral and maxillofacial region is unveiled.

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Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells

Cited by 72 publications

References 44 publications

Exosomes from oral tissue stem cells: biological effects and applications

Exosomes from oral tissue stem cells: biological effects and applications

Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases

Exosomes in the oral and maxillofacial region

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