Comparison of Immunologic Responses Following Intranasal and Oral Administration of a USDA-Approved, Live-Attenuated Streptococcus equi Vaccine

Delph, K. M.; Davis, Elizabeth G.; Bello, Nora M.; Hankins, Kevin; Wilkerson, Melinda J.; Ewen, Catherine

doi:10.1016/j.jevs.2016.08.015

Cited by 2 publications

(2 citation statements)

References 46 publications

(96 reference statements)

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“…On the other hand, presented in the form of a spray for nasal administration, there are the influenza vaccines against type A and B viruses (FluMist ® Quadrivalent and Nasovac-S™) [ 23 , 24 ]. Mucosal vaccines induce diverse immune responses in strength, efficiency, and long-term protection [ 25 , 26 , 27 ]. Most of these formulations contain live attenuated or inactivated whole-cell organisms or viruses [ 28 , 29 ]; consequently, the limitations and challenges are many, especially those related to safety.…”

Section: Mucosal Vaccinationmentioning

confidence: 99%

The Role of Mucoadhesion and Mucopenetration in the Immune Response Induced by Polymer-Based Mucosal Adjuvants

et al. 2023

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Mucus is a viscoelastic gel that acts as a protective barrier for epithelial surfaces. The mucosal vehicles and adjuvants need to pass through the mucus layer to make drugs and vaccine delivery by mucosal routes possible. The mucoadhesion of polymer particle adjuvants significantly increases the contact time between vaccine formulations and the mucosa; then, the particles can penetrate the mucus layer and epithelium to reach mucosa-associated lymphoid tissues. This review presents the key findings that have aided in understanding mucoadhesion and mucopenetration while exploring the influence of physicochemical characteristics on mucus–polymer interactions. We describe polymer-based particles designed with mucoadhesive or mucopenetrating properties and discuss the impact of mucoadhesive polymers on local and systemic immune responses after mucosal immunization. In future research, more attention paid to the design and development of mucosal adjuvants could lead to more effective vaccines.

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Section: Mucosal Vaccinationmentioning

confidence: 99%

The Role of Mucoadhesion and Mucopenetration in the Immune Response Induced by Polymer-Based Mucosal Adjuvants

et al. 2023

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“…Some pathogens such as Streptococcus equi, cause severe upper respiratory infections in horses since they attach to the equine tonsils (Sweeney et al, 2005). Nasal secretions of horses infected with S. equi or intranasally vaccinated with the USDA-approved S. equi live attenuated vaccine had specific IgA and IgG antibodies as well as systemic IgA titers (Galan and Timoney, 1985;Delph et al, 2018).…”

Section: Horses As Models Of Nasal Immunitymentioning

confidence: 99%

Comparative models for human nasal infections and immunity

Casadei

Salinas

2019

Developmental & Comparative Immunology

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Comparison of Immunologic Responses Following Intranasal and Oral Administration of a USDA-Approved, Live-Attenuated Streptococcus equi Vaccine

Abstract: Background: While there is a commercially-available vaccine for Streptococcus equi subsp. equi

Cited by 2 publications

References 46 publications

The Role of Mucoadhesion and Mucopenetration in the Immune Response Induced by Polymer-Based Mucosal Adjuvants

The Role of Mucoadhesion and Mucopenetration in the Immune Response Induced by Polymer-Based Mucosal Adjuvants

Comparative models for human nasal infections and immunity

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