Comparison of Immunoglobulin G Subclass Concentrations in Severe Community-Acquired Pneumonia and Severe Pandemic 2009 Influenza A (H1N1) Infection

Gordon, Claire L.; Holmes, Natasha E; Grayson, M. L.; Torresi, Joseph; Johnson, Paul D R; Cheng, Allen; Charles, Patrick G P

doi:10.1128/cvi.05518-11

Cited by 16 publications

(12 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar results have been obtained in the studies of Gordon et al 21 22 in which a decrease in serum levels of total IgG, IgG1 and IgG2 in patients with CAP with severe influenza H1N1 virus pneumonia as well in the remaining patients with severe non-influenza CAP. Although Gordon et al 11 21 established an association between acute low values of IgG2 and severe infection by influenza H1N1 virus, they could not determine whether this was due to the virus itself or to other factors of severity.…”

Section: Discussionsupporting

confidence: 90%

Serum levels of immunoglobulins and severity of community-acquired pneumonia

et al. 2016

View full text Add to dashboard Cite

InstructionThere is evidence of a relationship between severity of infection and inflammatory response of the immune system. The objective is to assess serum levels of immunoglobulins and to establish its relationship with severity of community-acquired pneumonia (CAP) and clinical outcome.MethodsThis was an observational and cross-sectional study in which 3 groups of patients diagnosed with CAP were compared: patients treated in the outpatient setting (n=54), patients requiring in-patient care (hospital ward) (n=173), and patients requiring admission to the intensive care unit (ICU) (n=191).ResultsSerum total IgG (and IgG subclasses IgG1, IgG2, IgG3, IgG4), IgA and IgM were measured at the first clinical visit. Normal cutpoints were defined as the lowest value obtained in controls (≤680, ≤323, ≤154, ≤10, ≤5, ≤30 and ≤50 mg/dL for total IgG, IgG1, IgG2, IgG3, IgG4, IgM and IgA, respectively). Serum immunoglobulin levels decreased in relation to severity of CAP. Low serum levels of total IgG, IgG1 and IgG2 showed a relationship with ICU admission. Low serum level of total IgG was independently associated with ICU admission (OR=2.45, 95% CI 1.4 to 4.2, p=0.002), adjusted by the CURB-65 severity score and comorbidities (chronic respiratory and heart diseases). Low levels of total IgG, IgG1 and IgG2 were significantly associated with 30-day mortality.ConclusionsPatients with severe CAP admitted to the ICU showed lower levels of immunoglobulins than non-ICU patients and this increased mortality.

show abstract

Section: Discussionsupporting

confidence: 90%

Serum levels of immunoglobulins and severity of community-acquired pneumonia

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The antibodies against p1 were mainly isotype IgG2, which is the most abundant in human sera. IgG2 isotype is less efficient for complement activation and antibody dependent cell‐mediated cytotoxicity than other isotypes, such as IgG1 . We propose that the effect of IgG2 isotype against peptide 1 could be the neutralization of the free virus, producing antiviral activity through the binding of antibodies to the receptor binding site of the HA and preventing the infection by the influenza virus .…”

Section: Discussionmentioning

confidence: 99%

A continuous peptide epitope reacting with pandemic influenza AH1N1 predicted by bioinformatic approaches

et al. 2015

View full text Add to dashboard Cite

Computational identification of potential epitopes with an immunogenic capacity challenges immunological research. Several methods show considerable success, and together with experimental studies, the efficiency of the algorithms to identify potential peptides with biological activity has improved. Herein, an epitope was designed by combining bioinformatics, docking, and molecular dynamics simulations. The hemagglutinin protein of the H1N1 influenza pandemic strain served as a template, owing to the interest of obtaining a scheme of immunization. Afterward, we performed enzyme-linked immunosorbent assay (ELISA) using the epitope to analyze if any antibodies in human sera before and after the influenza outbreak in 2009 recognize this peptide. Also, a plaque reduction neutralization test induced by virus-neutralizing antibodies and the IgG determination showed the biological activity of this computationally designed peptide. The results of the ELISAs demonstrated that the serum of both prepandemic and pandemic recognized the epitope. Moreover, the plaque reduction neutralization test evidenced the capacity of the designed peptide to neutralize influenza virus in Madin-Darby canine cells.

show abstract

“…For example, low concentrations of both immunoglobulin G (IgG) 1 and IgG-2 were found in patients with noninfluenza severe CAP, and low concentrations of IgG-2 were found in those with pneumonia due to influenza virus A (H1N1/09). 44 Mannose-binding lectin function was lower in those with Legionnaires' disease than in age-matched and sexmatched uninfected controls. 45 Homozygosity for the FCGR2A-H131 receptor predisposes to severe bacteremic pneumococcal pneumonia.…”

Section: Host Factorsmentioning

confidence: 85%

Severe Community-Acquired Pneumonia

Sligl

Marrie

2013

Critical Care Clinics

View full text Add to dashboard Cite

Severe community-acquired pneumonia necessitating intensive care unit admission is associated with high morbidity, mortality, and health-care cost. This review article serves to summarize the epidemiology, diagnosis, treatment, and prognosis of this common life-threatening condition. Current practice guidelines as well as the role of several scoring systems (such as the PSI, CURB-65, and IDSA/ATS criteria) used to predict CAP severity, prognosis, and site of care are reviewed. In addition, common complications and prevention strategies are discussed.

show abstract

Comparison of Immunoglobulin G Subclass Concentrations in Severe Community-Acquired Pneumonia and Severe Pandemic 2009 Influenza A (H1N1) Infection

Cited by 16 publications

References 11 publications

Serum levels of immunoglobulins and severity of community-acquired pneumonia

Serum levels of immunoglobulins and severity of community-acquired pneumonia

A continuous peptide epitope reacting with pandemic influenza AH1N1 predicted by bioinformatic approaches

Severe Community-Acquired Pneumonia

Contact Info

Product

Resources

About