Comparison of Immature Platelet Fraction (IPF) in Patients with Central Thrombocytopenia and Peripheral Thrombocytopenia

Abstract

Objective: To determine immature platelet fraction (IPF) in patients with thrombocytopenia and correlation with their bone marrow findings and to determine its predictive value in differentiating peripheral (hyper destructive) thrombocytopenia from central (hypo-productive) thrombocytopenia.

Reticulated Platelet Count as a Diagnostic Tool in Immune Thrombocytopenia (ITP)

“…Ashraf et al in their study found that patients with central thrombocytopenia had a median IPF of 8.2 (IQR=4.6-16.7), which was substantially lower than patients with peripheral thrombocytopenia, who had a median IPF of 25.5 (IQR=15.2-39.3) with a p-value of 0.001. IPF can thus be used to distinguish between central and peripheral thrombocytopenia, according to this study [ 7 ]. Additionally, Li et al discovered that the IPF% was significantly lower in the group with reduced platelet production compared to the control group.…”

“…These platelets reflect the bone marrow's ability to generate platelets and may be used as a surrogate marker for megakaryocytic activity [ 5 ]. According to studies, IPF is raised in patients with peripheral platelet destruction and decreased or normal in people who have central thrombocytopenia [ 2 , 6 , 7 ].…”