Comparison of IFN-γ Levels in Children with Tuberculosis Disease (TB) and Latent Tuberculosis Infection (LTBI)

Boskovska, Katerina; Naceva-Fustic, Stojka; Simonovska, Liljana; Dilberovska, Mirjana; Dacevski, D; Popova, G N; Arnaudova, Ivana; Cakalarovska, Irena

doi:10.3889/oamjms.2018.467

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…However, latent infection can become active at any time, hence identifying and treating these latent TB infections (LTBIs) can reduce the risk of development of active disease by up to 90%, thereby decreasing the major burden to the prevalence of the disease and thereby reducing potential sources in future. [4]…”

Section: Introductionmentioning

confidence: 99%

Validation and clinical application of interferon-gamma release assay for diagnosis of latent tuberculosis infection in children

Benachinmardi

Sangeetha

Rao

et al. 2019

Int J App Basic Med Res

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Background:India has the highest tuberculosis (TB) burden, accounting for one-fifth of the global incidence and two-third of the cases in Southeast Asia with an estimated 1.9 million new cases every year. Identifying and treating latent TB infection (LTBI) can reduce the risk of development of active disease by up to 90%, thereby decreasing a major burden to the prevalence of the disease, and thus reducing potential sources in future.Aim:Early diagnosis of LTBI by tuberculin skin test (TST) and a newer interferon-gamma release assay (IGRA).Materials and Methods:Seventy-seven clinically asymptomatic household contacts (≤18 years) of confirmed pulmonary TB patients were enrolled to compare the performance of TST and IGRA to diagnose LTBI. At baseline, all participants underwent testing for IGRA and TST.Results:TST showed positivity of 22%, while IGRA demonstrated positivity of 40% in the diagnosis of latent TB. Kappa value at 95% confidence interval was 0.4753, indicates a moderate agreement between the two tests. This indicates that IGRA is a better predictor of latent TB. Maximum positive percentage was in the age group of 16–18 years in both the tests followed by 1–5 years.Aim:Early diagnosis of LTBI by tuberculin skin test (TST) and a newer interferon-gamma release assay (IGRA).

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Section: Introductionmentioning

confidence: 99%

Validation and clinical application of interferon-gamma release assay for diagnosis of latent tuberculosis infection in children

Benachinmardi

Sangeetha

Rao

et al. 2019

Int J App Basic Med Res

View full text Add to dashboard Cite

show abstract

“…Till now, tuberculin skin test (TST) is mostly used for diagnosing LTBI. TST test is based on a "delayed hypersensitivity response" of infected patient to MTb [6]. However, there are several limitations for the TST that affect on findings of the test and cause false-positive results, including "Bacille Calmette-Guerin (BCG)" vaccine, and also corticosteroid therapy causes false-negative results [6].…”

Section: Introductionmentioning

confidence: 99%

“…TST test is based on a "delayed hypersensitivity response" of infected patient to MTb [6]. However, there are several limitations for the TST that affect on findings of the test and cause false-positive results, including "Bacille Calmette-Guerin (BCG)" vaccine, and also corticosteroid therapy causes false-negative results [6]. Todays, "interferon-γ release assays (IGRAs)" have introduced as an alternative for TST [7].…”

Section: Introductionmentioning

confidence: 99%

An updated systematic review on the applied TST and IGRA Test for diagnosing LTBI in patients treated with TNF-α inhibitor drugs

2019

Biointerface Res Appl Chem

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Present systematic review was designed to compare the efficacy of interferon-γ release assays (IGRAs) and tuberculin skin test (TST) for diagnosing latent tuberculosis infection (LTBI) in patients subjected to the anti-TNF-α therapy. The MEDLINE (Ovid), PubMed, Embase, Scopus, Cochrane library, and Web of Science ISI databases were searched for selecting studies to compare the efficiency of IGRAs [QuantiFERONTB Gold (QFT-GT), QuantiFERON-TB Gold In-Tube (QFT-GIT)and T-SPOT.TB] and TST in patients under the anti-TNF-α therapy. After evaluating all studies, we systemically reviewed the results of 37 studies with a total sample size of 8584 patients. The agreement between IGRASs and TST was poor to moderate, however, the anti-TNF-α therapy mostly decreased the percentage of this agreement. BCG vaccination could cause false results of TST assay. The developed active TB in patients with IGRAs positive results during follow-up showed lower than TST positive patients. In conclusion, in the treated patients with anti-TNF-α with previous BCG vaccination, IGRAs might be the better assay to diagnosis LTBI by reducing the false results rate in comparison with the TST. However, more investigations should be done to compare the advantage of IGRAs with conventional test in the treated patients with TNF-α antagonists.

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“…In children, TB usually develops as a result of close family contact with smear-positive TB patient. [1] Global incidence of tuberculosis (TB) is approximately 9.6 million cases. Of these, more than one third are in Asian countries: India, Indonesia, Myanmar, Thailand, Bangladesh, Pakistan, Sri Lanka, and Korea.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Clinico- Laboratory Profile of Tuberculosis in Children in Nobel Medical College, Biratnagar

Sah¹,

Giri²,

Niraula³

2019

J. Nepalgunj Med. College

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Introduction: Tuberculosis infection is very common, and it continues to be the major public health problem in Nepal. Published data about the epidemiology of TB in children is scarce in Nepal, though it is considered one of the most common causes of childhood morbidity in the country. Aims and objectives: To calculate the prevalence of tuberculosis in children aged 0-15 years and to study their clinico-laboratory profile. Methodology: This is a hospital based study conducted in Nobel Medical College Teaching Hospital, Biratnagar over a period of one year. We analyzed 289 children aged 0-15 years suspected of having tuberculosis on clinical grounds and subjected to further screening tests. Results: Majority of the children were males and most of the children were 5-15 years of age. 15 of the cases were diagnosed as tuberculosis out of which one case was bacteriologically confirmed pulmonary tuberculosis and be 5.2 %. Fever and cough were the most common clinical presentations and mantoux test and chest X-ray were most suggestive in majority of the cases. Conclusions: This study supports the use of history and thorough clinical examination and high index of clinical suspicion for diagnosis of childhood tuberculosis.

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Comparison of IFN-γ Levels in Children with Tuberculosis Disease (TB) and Latent Tuberculosis Infection (LTBI)

Cited by 3 publications

References 26 publications

Validation and clinical application of interferon-gamma release assay for diagnosis of latent tuberculosis infection in children

Validation and clinical application of interferon-gamma release assay for diagnosis of latent tuberculosis infection in children

An updated systematic review on the applied TST and IGRA Test for diagnosing LTBI in patients treated with TNF-α inhibitor drugs

Prevalence and Clinico- Laboratory Profile of Tuberculosis in Children in Nobel Medical College, Biratnagar

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