Comparison of <i>Tripterygium wilfordii</i> Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial

Lv, Qun; Zhang, Wen; Shi, Qun; Zheng, Wenjie; Li, Xin; Chen, Hua; Wu, Qingjun; Jiang, Wanlan; Li, Hongbin; Gong, Ling; Wei, Wei; Liu, Hui; Liu, Aijing; Jin, Hongtao; Wang, Jun-Xiang; Liu, Xiumei; Li, Zhenbin; Liu, Bin; Shen, Min; Wang, Qian; Wu, Xingcheng; Liang, Di; Yin, Yufeng; Fei, Yun-yun; Jing-mei, SU; Zhao, Lu; Jiang, Ying; Li, Jing; Tang, Fu-lin; Zhang, Fengchun; Lipsky, Peter E.; Zhang, Xuan

doi:10.1136/annrheumdis-2013-204807

Cited by 180 publications

(163 citation statements)

References 23 publications

(21 reference statements)

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“…1 We completely agree with the readers that the study must be interpreted with caution because it was carried out in an open-label manner owing to cost considerations. We discussed this in detail in the section on Limitations in the Discussion of the paper.…”

supporting

confidence: 52%

The TRIFRA trial: efforts employed to minimise expectation bias

Zhang

Shi

et al. 2014

Ann Rheum Dis

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supporting

confidence: 52%

The TRIFRA trial: efforts employed to minimise expectation bias

Zhang

Shi

et al. 2014

Ann Rheum Dis

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“…The anti-inflammatory and immunosuppressive effect of TwHF is comparable with MTX. Moreover, TwHF combination with MTX may be better than TwHF or MTX monotherapy [17]. Although much work is still needed to be done, MTX combinations with TwHF or other DMARDs are effective in the management of patients with RA.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Methotrexate with Tripterygium wilfordii Hook F in the Management of Rheumatoid Arthritis

Ye¹,

Chen²

2015

J Bioanal Biomed

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“…There is an increasing interest in the role of complementary and alternative medicine (CAM) in rheumatoid arthritis (RA) [1][2][3]. However, their application in routine care needs careful consideration of safety and reliability.…”

Section: Abstract Traditional Chinese Medicine · Complementary and Almentioning

confidence: 99%

“…using accepted disease activity measures, such as the ACR response criteria [1,4]. Their safety profile in those trials was reassuring.…”

mentioning

confidence: 98%

Traditional Chinese medication for rheumatoid arthritis: more than what meets the eye

Santosa

Teng

2014

Rheumatol Int

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There is an increasing interest in the role of traditional Chinese medicine (TCM) in rheumatoid arthritis (RA), as evidenced by recent trials comparing their efficacy against established disease-modifying antirheumatic drugs. While the TCM in these trials seem to support a favorable cost-benefit ratio, many products are marketed under the guise of TCM, potentially exposing the user to unpredicted adverse events. We present the case of a patient with RA, who developed side effects from treatment with adulterated TCM. While TCM may be of value in the treatment of rheumatic diseases, their application in routine care continues to warrant careful consideration of safety and reliability.

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Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial

Abstract: NCT01613079.

Cited by 180 publications

References 23 publications

The TRIFRA trial: efforts employed to minimise expectation bias

The TRIFRA trial: efforts employed to minimise expectation bias

Comparison of Methotrexate with Tripterygium wilfordii Hook F in the Management of Rheumatoid Arthritis

Traditional Chinese medication for rheumatoid arthritis: more than what meets the eye

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