Comparison of hyperbaric and plain ropivacaine 15 mg in spinal anaesthesia for lower limb surgery

Kallio, H.; Snäll, E.-V. T.; Tuomas, Carl A.; Rosenberg, P. H.

doi:10.1093/bja/aeh257

Cited by 54 publications

(60 citation statements)

References 10 publications

(10 reference statements)

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“…Difference in the onset of motor blockade in both groups was also found to be statistically significant (P <0.05). These findings of present study are similar with the findings stated by Van [17][18][19][20][21][22] The duration of sensory blockade was defined as time elapsed between injection of study drug and return of the pin prick sensation whereas duration of motor blockade was defined as time between drug injections to complete return of motor power with movement of all lower limb joints. It was found that longer duration of sensory and motor blockade in bupivacaine group as against in ropivacaine group and difference was statistically significant (P <0.05).…”

Section: Discussionsupporting

confidence: 91%

A double blind prospective study of effect of intrathecal ropivacaine 0.75% and bupivacaine 0.5% for lower limb orthopedic surgery in young patients

Sule¹,

Basantwani²

2016

Int J Basic Clin Pharmacol

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Section: Discussionsupporting

confidence: 91%

A double blind prospective study of effect of intrathecal ropivacaine 0.75% and bupivacaine 0.5% for lower limb orthopedic surgery in young patients

Sule¹,

Basantwani²

2016

Int J Basic Clin Pharmacol

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“…Usually, glucose-free solutions are marginally hypobaric and have been found previously to be 'unpredictably' (Logan et al, 1986) spread. Many studies (Fettes et al, 2005;Whiteside et al, 2001;Kallio et al, 2004) showed that hyperbaric solutions of local anesthetics for spinal anesthesia produce a more rapid spread to a higher median level and less variation in maximum sensory and motor block and might enable a smaller dose to be used compared with plain solutions. Especially in pregnant women, the width of the hips is usually larger than the shoulders which result in a head-down tilt when lying in the lateral position (Khaw et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Dose-response study of spinal hyperbaric ropivacaine for cesarean section

Chen

Lou

et al. 2006

J. Zhejiang Univ. - Sci. B

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Abstract:Background: Spinal hyperbaric ropivacaine may produce more predictable and reliable anesthesia than plain ropivacaine for cesarean section. The dose-response relation for spinal hyperbaric ropivacaine is undetermined. This double-blind, randomized, dose-response study determined the ED50 (50% effective dose) and ED95 (95% effective dose) of spinal hyperbaric ropivacaine for cesarean section anesthesia. Methods: Sixty parturients undergoing elective cesarean section delivery with use of combined spinal-epidural anesthesia were enrolled in this study. An epidural catheter was placed at the L1~L2 vertebral interspace, then lumbar puncture was performed at the L3~L4 vertebral interspace, and parturients were randomized to receive spinal hyperbaric ropivacaine in doses of 10.5 mg, 12 mg, 13.5 mg, or 15 mg in equal volumes of 3 ml. Sensory levels (pinprick) were assessed every 2.5 min until a T7 level was achieved and motor changes were assessed by modified Bromage Score. A dose was considered effective if an upper sensory level to pin prick of T7 or above was achieved and no intraoperative epidural supplement was required. ED50 and ED95 were determined with use of a logistic regression model. Results: ED50 (95% confidence interval) of spinal hyperbaric ropivacaine was determined to be 10.37 (5.23~11.59) mg and ED95 (95% confidence interval) to be 15.39 (13.81~23.59) mg. The maximum sensory block levels and the duration of motor block and the rate of hypotension, but not onset of anesthesia, were significantly related to the ropivacaine dose. Conclusion: The ED50 and ED95 of spinal hyperbaric ropivacaine for cesarean delivery under the conditions of this study were 10.37 mg and 15.39 mg, respectively. Ropivacaine is suitable for spinal anesthesia in cesarean delivery.

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“…Khaw KS et al, [2]; Gupta R et al, [8]; Kallio H et al, [10]; Fettes PD et al, [11] observed that median time taken for complete regression of sensory and motor blockade were significantly shorter in hyperbaric group than in isobaric group.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study between Intrathecal Hyperbaric and Isobaric Ropivacaine in Geriatric Patients, Undergoing Lower Limb Plastic Surgical Procedures

S¹,

Jan²,

Ahmad³

2017

IJAR

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Comparison of hyperbaric and plain ropivacaine 15 mg in spinal anaesthesia for lower limb surgery

Abstract: In comparison with the plain solution, 15 mg of intrathecal hyperbaric ropivacaine produced a faster onset, greater success rate of analgesia at the level of T(10) dermatome, and faster recovery of the block.

Cited by 54 publications

References 10 publications

A double blind prospective study of effect of intrathecal ropivacaine 0.75% and bupivacaine 0.5% for lower limb orthopedic surgery in young patients

A double blind prospective study of effect of intrathecal ropivacaine 0.75% and bupivacaine 0.5% for lower limb orthopedic surgery in young patients

Dose-response study of spinal hyperbaric ropivacaine for cesarean section

Comparative Study between Intrathecal Hyperbaric and Isobaric Ropivacaine in Geriatric Patients, Undergoing Lower Limb Plastic Surgical Procedures

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