Comparison of Hydroxyzine and Doxepin in Treatment of Pruritus Due to Sulfur Mustard

Shohrati, Majid; Tajik, Ali; Harandi, Ali Amini; Davoodi, Seyed Masoud; Akmasi, Mahmood

doi:10.1111/j.1540-9740.2007.05880.x

Cited by 28 publications

(22 citation statements)

References 29 publications

(24 reference statements)

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“…In addition, studies have shown the relief of uremic pruritus following the use of granisetron (33), gabapentin (21), cromolyn sodium, and pimecrolimus cream (32).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Afrasiabifar¹,

Mehri²,

Hosseini³

2016

Iran Red Crescent Med J

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“…In addition, studies have shown the relief of uremic pruritus following the use of granisetron (33), gabapentin (21), cromolyn sodium, and pimecrolimus cream (32).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Afrasiabifar¹,

Mehri²,

Hosseini³

2016

Iran Red Crescent Med J

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“…To control of the itching, systemic antihistamines, and topical corticosteroids were used regularly. With regards to side effects of corticosteroids some alternatives were recommended such as cetirizine, curcumin, capsaicin, doxepin, aloe vera/olive oil combination, hydroxyzine, phenol/menthol combination, Unna's Boot, and pimecrolimus …”

Section: Treatment Protocols In Sm Exposed Victimsmentioning

confidence: 99%

A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard‐exposed victims

Panahi

Abdolghaffari

Sahebkar

2017

J of Cellular Biochemistry

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Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apoptosis, and inflammation. Sulfur mustard penetrated body organs and induces long term eye, skin, lung, gastrointestinal, urogenital damages and can cause carcinogenic and mutagenic consequences. Currently there is no definitive treatment protocol for SM exposed patients. The goal of treatment is relieving the symptoms with fast healing rate and retrieval of damaged tissues to normal function and appearance in short period of time. Evaluation of proteomics profile in SM-exposed victims has been performed in animal model and human patients. These studies revealed that different protein were involved in the patients with SM damages to skin and lungs. Apolipoprotein A1, type I cytokeratins K14, K16 and K17, S100 calcium-binding protein A8, α1 haptoglobin isoforms, Amyloid A1, albumin, haptoglobin, and keratin isoforms, immunoglobulin kappa chain are defined expressed proteins in the damaged tissues.

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“…The tricyclic antidepressant doxepin is used topically and systemically for its additive antihistaminic and anticholinergic effects in pruritus. In a study on mustard gas‐induced pruritus, doxepin and the sedating antihistamine hydroxyzine were about equally effective in three‐fourths of patients 60 …”

Section: Therapy Of Pruritusmentioning

confidence: 99%

Chronic pruritus – pathogenesis, clinical aspects and treatment

Metz

Ständer

2010

Acad Dermatol Venereol

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Chronic pruritus is a major symptom in numerous dermatological and systemic diseases. Similar to chronic pain, chronic pruritus can have a dramatic impact on the quality of life and can worsen the general condition of the patient considerably. The pathogenesis of itch is diverse and involves a complex network of cutaneous and neuronal cells. In recent years, more and more itch-specific mediators and receptors, such as interleukin-31, gastrin-releasing peptide receptor or histamine H4 receptor have been identified and the concept of itch-specific neurons has been further characterized. Understanding of the basic principles is important for development of target-specific treatment of patients with chronic pruritus. In this review, we summarize the current knowledge about the pathophysiological principles of itch and provide an overview about current and future treatment options.

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Comparison of Hydroxyzine and Doxepin in Treatment of Pruritus Due to Sulfur Mustard

Abstract: Both hydroxyzine and doxepin are effective and have equivalent results in controlling the symptoms of patients with chronic pruritus due to exposure to sulfur mustard.

Cited by 28 publications

References 29 publications

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

Efficacy of Topical Application of Sweet Almond Oil on Reducing Uremic Pruritus in Hemodialysis Patients: A Randomized Clinical Trial Study

A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard‐exposed victims

Chronic pruritus – pathogenesis, clinical aspects and treatment

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