Comparison of Hydrocolloid Dressings and Silver Nanoparticles in Treatment of Pressure Ulcers in Patients with Spinal Cord Injuries: A Randomized Clinical Trial

Asgari, Parvaneh; Zolfaghari, Mitra; Bit-Lian, Yee; Abdi, Amir Hossien; Mohammadi, Younes; Bahramnezhad, Fatemeh

doi:10.34172/jcs.2022.08

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…23,24 Another report mentioned the use of ultrasound jelly to seal the wound when applying NPWT to the foot, 25 but this was not appropriate in these moisture-prone areas in this study. Hydrocolloid dressings have been widely used in a variety of acute and chronic wounds, such as pressure injuries and post-operative incisions, [26][27][28] and have also shown good results in the treatment of severe diaper dermatitis, 29 demonstrating their moisture-defying, tightly adherent, skin friendly, and comfortable properties. The combined application of hydrocolloid dressings and NPWT was described and analysed in detail for the first time in this study, extending the range of applications for hydrocolloid dressings.…”

Section: Discussionmentioning

confidence: 99%

Effect of hydrocolloid dressings on preventing air leakage when applying negative pressure wound therapy to the perineum, buttocks, and sacrococcygeal region

Wang,

Li,

et al. 2024

Wound Repair Regeneration

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Maintaining a vacuum when applying NPWT is the key to its function, which is a challenge in the perineum, buttocks, and sacrococcygeal region. A retrospective cohort study was conducted to assess the effect of hydrocolloid dressings on preventing air leakage when applying NPWT in these regions. There were 61 patients in Group A (without the aid of hydrocolloid dressings) and 65 patients in Group B (with the aid of hydrocolloid dressings). The hydrocolloid dressing‐assisted NPWT significantly reduced the incidence of air leakage compared with conventional NPWT placement (24.6% vs 7.7%; risk ratio 3.20, 95% confidence interval 1.24 to 8.27; P = 0.009), while decreasing the number of open NPWT applications (2.2 vs 1.7; difference, 0.43; 95% confidence interval, 0.19 to 0.66; P < 0.001), shortening hospital stays (20.1 vs 16.1; difference, 4.07; 95% confidence interval, 1.68 to 6.46; P = 0.01), and reducing the incidence of adverse skin events (18.0% vs 4.6%; risk ratio 3.91, 95% confidence interval 1.14 to 13.34; P = 0.017). These findings support the routine use of hydrocolloid dressing‐assisted NPWT placement in the perineum, buttocks, and sacrococcygeal region.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Effect of hydrocolloid dressings on preventing air leakage when applying negative pressure wound therapy to the perineum, buttocks, and sacrococcygeal region

Wang,

Li,

et al. 2024

Wound Repair Regeneration

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“…To check the effectiveness of silver nanoparticle dressings, Asgari and his team [ 89 ] conducted a study in which they explored their effectivity in the treatment of pressure ulcers with spinal cord injuries. 70 patients suffering from spinal cord injury were enrolled in the study and then divided into two equal groups, one was receiving a hydrocolloid dressing and the other an AgNPs-based dressing.…”

Section: Clinical Application Of Wound Dressings Containing Silver An...mentioning

confidence: 99%

Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing—From Experimental Studies to Clinical Practice

Rybka

Mazurek

Konop

2022

Life

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Impaired wound healing affects hundreds of million people around the world; therefore, chronic wounds are a major problem not only for the patient, but also for already overloaded healthcare systems. Chronic wounds are always very susceptible to infections. Billions of dollars are spent to discover new antibiotics as quickly as possible; however, bacterial resistance against antibiotics is rising even faster. For this reason, a complete shift of the antibacterial treatment paradigm is necessary. The development of technology has allowed us to rediscover well-known agents presenting antimicrobial properties with a better outcome. In this context, silver nanoparticles are a promising candidate for use in such therapy. Silver has many useful properties that can be used in the treatment of chronic wounds, such as anti-bacterial, anti-inflammatory, and anti-oxidative properties. In the form of nanoparticles, silver agents can work even more effectively and can be more easily incorporated into various dressings. Silver-based dressings are already commercially available; however, innovative combinations are still being discovered and very promising results have been described. In this review article, the authors focused on describing experimental and clinical studies exploring dressings containing either silver or silver nanoparticles, the results of which have been published in recent years.

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Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Pathi,

Mishra,

Moharana

et al. 2024

Cureus

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Background: Infected wounds pose a special challenge for management, with an increased risk of wound chronicity, systemic infection, and the emergence of antibiotic resistance. Silver nanoparticles have multimodal effects on bacteria clearance and wound healing. This study aimed to document the efficacy of a topical silver nanoparticle-based cream on bacteria clearance and wound healing in infected wounds compared to Mupirocin.Methods: This open-label parallel randomized clinical trial allocated 86 participants with infected wounds (culture-positive) into Kadermin, silver nanoparticle-based cream arm (n=43) and Mupirocin arm (n=43) and documented the swab culture on day 5 and wound healing at day 28, along with periodic wound status using the Bates-Jensen Wound Assessment Tool. Patients received oral/systemic antibiotics and other medications for underlying diseases. The intention-to-treat principle was adopted for data analysis using the chi-square and Student t tests to document the differences between groups according to variable characteristics.Results: All participants completed the follow-up. On day 5, wound bacteria clearance was observed in 86% and 65.1% of the participants in the Kadermin and Mupirocin arms, respectively (p=0.023). At day 28, complete wound healing was observed in 81.4% and 37.2% of the participants in the Kadermin and Mupirocin arms, respectively (p≤0.001). No local or systemic adverse event or local reaction was observed in any of the participants. Conclusion: Kadermin, the silver nanoparticle-based cream, has better efficacy in achieving faster wound bacteria clearance and healing in infected wounds compared to Mupirocin. This may have relevance for its use as an antibiotic-sparing agent in wound management.

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Comparison of Hydrocolloid Dressings and Silver Nanoparticles in Treatment of Pressure Ulcers in Patients with Spinal Cord Injuries: A Randomized Clinical Trial

Cited by 3 publications

References 25 publications

Effect of hydrocolloid dressings on preventing air leakage when applying negative pressure wound therapy to the perineum, buttocks, and sacrococcygeal region

Effect of hydrocolloid dressings on preventing air leakage when applying negative pressure wound therapy to the perineum, buttocks, and sacrococcygeal region

Beneficial Effect of Wound Dressings Containing Silver and Silver Nanoparticles in Wound Healing—From Experimental Studies to Clinical Practice

Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

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