Comparison of human amniotic membrane and collagen nerve wraps around sciatic nerve reverse autografts in a rat model

Wolfe, Erin M.; Mathis, Sydney A.; Muñoz, Natalia de la Olivo; Ovadia, Steven; Panthaki, Zubin J.

doi:10.1016/j.bbiosy.2022.100048

Cited by 3 publications

(2 citation statements)

References 40 publications

(78 reference statements)

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“…The pain from extra-neural scarring may itself result from several different mechanisms: impairment of epineural blood flow leading to nerve ischaemia, circumferential scarring causing mechanical compression of the nerve, and adhesions prohibiting gliding of the nerve leading to traction neuritis [9,10]. Traction neuritis may be further compounded if adjacent tendons or other neighbouring structures are injured, increasing the risk of adhesions to tendons or skin.…”

Section: Discussionmentioning

confidence: 99%

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The Double-Opposing Adipofascial Interposition Flap: A Novel Technique to Prevent Scar Tethering and Symptomatic Neuroma of the Superficial Radial Nerve After Trauma

Kulenkampff,

Choudhary,

O'Hara

et al. 2023

Cureus

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The superficial radial nerve (SRN) is vulnerable to injury following trauma with a high incidence of resultant nerve tether and neuroma formation. The SRN has an anatomical predisposition to neuroma formation, with research indicating that its propensity to neuroma development is out of proportion with its likelihood for injury. In addition, SRN neuromas have been described as one of the more painful and difficult neuromas to manage. Despite this, the published literature to date is chiefly focused on neuroma and scar tether treatment options rather than more impactful work on neuroma prevention, which can be safely delivered at the time of primary surgery. Treatment of established neuroma or nerve tether is notoriously difficult, and existing techniques have inconsistent outcomes, with patients often requiring multiple trips to the theatre. The authors present a novel technique for neuroma and scar tether prevention using an adipofascial flap accompanied by patient examples of our experience using this approach as an adjunct during the primary SRN repair, creating a gliding, interposing layer to prevent subsequent nerve traction pain and symptomatic neuroma.We identified five patients presenting with dorsal wrist injuries involving the SRN and one or more tendons. Patients' follow-up duration was a mean of 3.5 months (one to eight months). All follow-up patients showed no symptoms of a neuroma or nerve tether pain. All patients were discharged without re-referral or further surgery. Our patient sample demonstrates promising results using an adipofascial interposition flap as a prophylactic measure in traumatic injuries to reduce nerve tether pain and symptomatic neuroma formation in the SRN.

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Section: Discussionmentioning

confidence: 99%

“…Artificial and biological substitutes aim to use synthetic or collagen matrices to provide support and prevent external tethering. However, they are expensive, can inhibit neovascularisation, and potentially cause oedema and fibrosis [9,13]. Various autologous tissues have been studied as an adjunct to neurolysis.…”

Section: Discussionmentioning

confidence: 99%

The Double-Opposing Adipofascial Interposition Flap: A Novel Technique to Prevent Scar Tethering and Symptomatic Neuroma of the Superficial Radial Nerve After Trauma

Kulenkampff,

Choudhary,

O'Hara

et al. 2023

Cureus

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Amniotic Membrane‐Derived Multichannel Hydrogels for Neural Tissue Repair

Sousa,

Deus,

Monteiro

et al. 2024

Adv Healthcare Materials

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In the pursuit of advancing neural tissue regeneration, biomaterial scaffolds have emerged as promising candidates, offering potential solutions for nerve disruptions. Among these scaffolds, multichannel hydrogels, characterized by meticulously designed micrometer‐scale channels, stand out as instrumental tools for guiding axonal growth and facilitating cellular interactions. This study explores the innovative application of human amniotic membranes modified with methacryloyl domains (AMMA) in neural stem cell (NSC) culture. AMMA hydrogels, possessing a tailored softness resembling the physiological environment, are prepared in the format of multichannel scaffolds to simulate native‐like microarchitecture of nerve tracts. Preliminary experiments on AMMA hydrogel films showcase their potential for neural applications, demonstrating robust adhesion, proliferation, and differentiation of NSCs without the need for additional coatings. Transitioning into the 3D realm, the multichannel architecture fosters intricate neuronal networks guiding neurite extension longitudinally. Furthermore, the presence of synaptic vesicles within the cellular arrays suggests the establishment of functional synaptic connections, underscoring the physiological relevance of the developed neuronal networks. This work contributes to the ongoing efforts to find ethical, clinically translatable, and functionally relevant approaches for regenerative neuroscience.

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Comparative analysis of aligned and random amniotic membrane-derived cryogels for neural tissue repair

Sousa,

Deus,

Monteiro

et al. 2024

Biomater. Sci.

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Comparison of human amniotic membrane and collagen nerve wraps around sciatic nerve reverse autografts in a rat model

Cited by 3 publications

References 40 publications

The Double-Opposing Adipofascial Interposition Flap: A Novel Technique to Prevent Scar Tethering and Symptomatic Neuroma of the Superficial Radial Nerve After Trauma

The Double-Opposing Adipofascial Interposition Flap: A Novel Technique to Prevent Scar Tethering and Symptomatic Neuroma of the Superficial Radial Nerve After Trauma

Amniotic Membrane‐Derived Multichannel Hydrogels for Neural Tissue Repair

Comparative analysis of aligned and random amniotic membrane-derived cryogels for neural tissue repair

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