Comparison of HPV detection technologies: Hybrid capture 2, PreTect™ HPV-Proofer and analysis of HPV DNA viral load in HPV16, HPV18 and HPV33 E6/E7 mRNA positive specimens

Keegan, Helen; Inerney, Jamie Mc; Pilkington, Loretto; Grønn, Petter; Silva, Ivan; Karlsen, Frank; Bolger, Noel; Logan, Catriona; Furuberg, Liv; O’Leary, John; Martín, C

doi:10.1016/j.jviromet.2008.09.027

Cited by 40 publications

(44 citation statements)

References 29 publications

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“…That marker might be used to reduce the number of women referred to a more careful monitoring and follow-up regime, raising the specificity of assessment in women with atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesions (LSILs) (Varnai et al, 2008;Keegan et al, 2009;Brown and Trimble, 2012;Tornesello et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less

et al. 2016

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ABSTRACT. We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. Negative results of mRNA expression were in accordance with negative cytologies. In positive cases, the infection by a single HPV type was most common, with type 16 being most prevalent. The expression of mRNA was most prevalent in ASC-US and LSIL cytologies, compared with the negative cytology. The infection by a HPV type was more frequent in cases of positive expression, with HPV

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Section: Introductionmentioning

confidence: 99%

Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less

et al. 2016

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“…The sensitivity for moderate dysplasia or worse is lower, but the specificity is higher (Cattani et al, 2009a;Keegan et al, 2009;Lie et al, 2005;Szarewski et al, 2008). It is well-known that many cervical lesions with moderate or severe dysplasia will regress spontaneously.…”

mentioning

confidence: 99%

HPV mRNA test in women with minor cervical lesions: Experience of the University Hospital of North Norway

Sørbye

Fismen

Gutteberg

et al. 2010

Journal of Virological Methods

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“…HPV 33 was the second most common type in ASC-US and LSIL cytologies, and type 45 in negative cytologies; Sorbye et al, 2011, andKeegan et al, 2009, also found the type 33 as the second most prevalent type. No great prevalence of HPV 18 was seen in the three cytologies.…”

Section: Discussionmentioning

confidence: 86%

Expression of Messenger RNA of Oncoproteins E6 and E7 of Human Papilomavirus in Women with Negative Oncotic Cytologies, Epithelial Squamous Atypias of Undefined Significance and Low-Grade Intraepithelial Lesions

Casagrande¹,

Ribalta²,

Leite³

et al. 2015

OJOG

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Comparison of HPV detection technologies: Hybrid capture 2, PreTect™ HPV-Proofer and analysis of HPV DNA viral load in HPV16, HPV18 and HPV33 E6/E7 mRNA positive specimens

Cited by 40 publications

References 29 publications

Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less

Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less

HPV mRNA test in women with minor cervical lesions: Experience of the University Hospital of North Norway

Expression of Messenger RNA of Oncoproteins E6 and E7 of Human Papilomavirus in Women with Negative Oncotic Cytologies, Epithelial Squamous Atypias of Undefined Significance and Low-Grade Intraepithelial Lesions

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