Comparison of Host Cytokine Response in Piglets Infected With Toxigenic and Non-toxigenic Staphylococcus hyicus

Li, Yan; Gou, Hongchao; Chu, Pinpin; Zhang, Kunli; Jiang, Zhi‐Yong; Cai, Rujian; Song, Sooyeon; Bian, Zhibiao; Li, Chunling

doi:10.3389/fvets.2021.639141

Cited by 2 publications

(3 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current analysis shows outstanding prediction accuracy, a significant improvement over Alizadeh Sani et al research work (13). The RNN-LSTM highest AUROC used in this investigation received (.99), outperforming Yu et al review study (15). Traditional procedures, such as angiography, cannot be replaced by this prediction system.…”

Section: Discussionmentioning

confidence: 60%

“…The inflammatory profile of mature patients with the disease of mouth, foot, and hand, joint in the Asia-Pacific area, was studied using cytokines by Ling-Hua Yu et al (15). Participants used a random forest to identify the (HFMD) illness collection from controls using 26 key cytokines as predictive characteristics (24).…”

Section: Literature Reviewmentioning

confidence: 99%

“…By targeting active receptors and generating downstream signals, they operate as messengers to other cells. Lymphokines, chemokines, interferons, and interleukins are examples of cytokines responding to environmental signals that initiate an anti-inflammatory or procascade response (14,15). Cytokines have been linked to the progression and development of coronary artery disease (9).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advanced detection of coronary artery disease via deep learning analysis of plasma cytokine data

Shoaib,

Junaid,

Husnain

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The 2017 World Health Organization Fact Sheet highlights that coronary artery disease is the leading cause of death globally, responsible for approximately 30% of all deaths. In this context, machine learning (ML) technology is crucial in identifying coronary artery disease, thereby saving lives. ML algorithms can potentially analyze complex patterns and correlations within medical data, enabling early detection and accurate diagnosis of CAD. By leveraging ML technology, healthcare professionals can make informed decisions and implement timely interventions, ultimately leading to improved outcomes and potentially reducing the mortality rate associated with coronary artery disease. Machine learning algorithms create non-invasive, quick, accurate, and economical diagnoses. As a result, machine learning algorithms can be employed to supplement existing approaches or as a forerunner to them. This study shows how to use the CNN classifier and RNN based on the LSTM classifier in deep learning to attain targeted “risk” CAD categorization utilizing an evolving set of 450 cytokine biomarkers that could be used as suggestive solid predictive variables for treatment. The two used classifiers are based on these “45” different cytokine prediction characteristics. The best Area Under the Receiver Operating Characteristic curve (AUROC) score achieved is (0.98) for a confidence interval (CI) of 95; the classifier RNN-LSTM used “450” cytokine biomarkers had a great (AUROC) score of 0.99 with a confidence interval of 0.95 the percentage 95, the CNN model containing cytokines received the second best AUROC score (0.92). The RNN-LSTM classifier considerably beats the CNN classifier regarding AUROC scores, as evidenced by a p-value smaller than 7.48 obtained via an independent t-test. As large-scale initiatives to achieve early, rapid, reliable, inexpensive, and accessible individual identification of CAD risk gain traction, robust machine learning algorithms can now augment older methods such as angiography. Incorporating 65 new sensitive cytokine biomarkers can increase early detection even more. Investigating the novel involvement of cytokines in CAD could lead to better risk detection, disease mechanism discovery, and new therapy options.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Literature Reviewmentioning

confidence: 99%