Comparison of honey and dextrose solution on post-operative peritoneal adhesion in rat model

Rahimi, Vafa Baradaran; Shirazinia, Reza; Fereydouni, Narges; Zamani, Parvin; Darroudi, Sousan; Sahebkar, Amirhosein; Askari, Vahid Reza

doi:10.1016/j.biopha.2017.05.114

Cited by 57 publications

(62 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress is considered one of the most important factors responsible for adhesion formation [27]. Therefore, in the present study, we evaluated the levels of NO and MDA as oxidative factors and GSH as an antioxidative agent.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

et al. 2020

Self Cite

View full text Add to dashboard Cite

Postoperative adhesions are regarded as the major complication following abdominal surgery. Rosmarinus officinalis has shown antioxidative and anti-inflammatory effects. Therefore, we aimed to assess the influence of 70% v/v hydro-ethanolic extract of the aerial parts of R. officinalis against postoperative abdominal adhesions in a rat model. Forty-eight male Wistar rats (190 ± 20 g) were divided into six groups of eight: group 1 = normal group, without any surgical procedures, group 2 = control group, group 3 = vehicle group, and groups 3, 4, and 5 = experimental groups receiving 2 mL of 4, 2, or 1% w/v R. officinalis treatment. Adhesion levels were macroscopically examined. Additionally, the levels of inflammatory cytokines (interleukin-6, interleukin-1β, and TNF-α), growth factors (transforming growth factor-β1, and vascular endothelial growth factor), oxidative (NO, nitric oxide and MDA, malondialdehyde), and antioxidative (GSH, glutathione) factors were evaluated. Our results revealed that the adhesion score, interleukin-6, interleukin-1β, TNF-α, transforming growth factor-β1, vascular endothelial growth factor, NO, and MDA levels were significantly increased in the vehicle group, while the GSH level was diminished. R. officinalis treatment notably ameliorated the adhesion score following postoperative abdominal adhesions compared with the vehicle group. Our results also revealed that R. officinalis markedly reduced inflammatory cytokines, oxidative factors, fibrosis, and angiogenesis biomarkers, whereas it increased the antioxidative factor. Therefore, R. officinalis may be a potential candidate for the management of postoperative peritoneal adhesion.

show abstract

Section: Discussionmentioning

confidence: 98%

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Arslan et al [7] found that blood MDA levels were higher in the adhesion group than in the control group. In another study, it was observed that in the comparison of the GSH level between the normal group and adhesion group, the decrease in the adhesion group was found to be at a significant level whereas the MDA level was found to be higher and more important in the adhesion group compared to the normal group [40]. In another study, the difference in MDA level between the control group and sham groups was found to be significant [6].…”

Section: Discussionmentioning

confidence: 90%

Surgery-Induced Changes in Erythrocyte and Plasma Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidants of Female Rats: Protective Role of Heparin and Pentoxifylline

Şimşek

Durmuş

Yıldız

et al. 2018

Acta Scientiae. Vet.

View full text Add to dashboard Cite

Background: Intra abdominal adhesions are a complication that occurs after many abdominal surgical procedures, especially gynecological operations. These complications occur by irritating the peritoneum due to such circumstances as infection or surgical trauma, and are considered a pathological part of the healing process of peritoneal injury. It manifests itself with symptoms such as pain, intestinal or urethral obstruction and abdominal abscesses. Oxidative stress due to adhesions plays an important role on adhesion formation. In addition to many researches done at the point of prevention of adhesion and decreasing stress parameters, in this study, it was planned to determine the effect of Heparin (H) and Pentoxifylline (PTX) on malondialdehyde (MDA) and some antioxidant values.Materials, Methods & Results: This study was performed on rats and thirty-seven female Sprague-Dawley rats were randomized into four groups. The first group was sham (Sh) group (n = 7) and laparotomy was performed and 2 mL of 0.9 % NaCl was applied. For all other rats (n = 30) the small intestine was withdrawn and the uterus was uncovered and the anti mesenteric surfaces of the left uterine horn and left abdominal wall were superficially tilted until slight bleeding was seen. Lesion areas have been covered. Two mL 0.9 % NaCl to control (C) group (n = 10), 500 IU heparin to group H, and 25 mg / kg Pentoxifylline to group PTX (n = 10) have been given and then the abdominal incision was closed. The adhesion score of group Sh was found to be more important than C and PTX groups (P < 0.05). The adhesion score of group C was determined to be more significant than group H (P < 0.05). In group Sh, erythrocyte reduced glutathione (GSH) levels were found to be more significant (P < 0.01) than C, H and PTX groups whereas it was found that group C was more significant than group H (P < 0.01). In group Sh, glutathione peroxidase (GSH-Px) activity was found to be more significant (P < 0.05) than H and PTX groups, while MDA level was found to be lower and more significant (P < 0.01) than group C. In addition, group C was found to be higher and more significant (P < 0.01) than group H. Plasma vitamin E levels in Sh, H and PTX groups were found to be higher and more significant (P < 0.01) than group C. It is also observed that MDA levels in group C are higher and more significant (P < 0.01) than all groups. Nitric oxide (NO) level in Sh group was found to be lower and more significant (P < 0.05) than the other groups whereas it is determined that NO level in H group is higher and more significant (P < 0.05) than group C. Activites of erythrocyte catalase (CAT) and superoxide dismutase (SOD), the levels of plasma vitamin A and β-carotene were not important in all groups.Discussion: Intra abdominal adhesions that occur due to operations performed in the abdominal region still remain as a major problem. This adhesion brings certain problems with itself. Various applications have been made to reduce these problems. In this study, it was observed that inhibition of heparin and pentoxifylline adhesions contributed to the reduction of MDA levels and the reduction of oxidative damage due to the increase in levels of Vitamin E, GSH, GSH-Px and NO levels. In conclusion, it is suggested that heparin and pentoxifylline should be used to prevent adhesions due to abdominal operations and to reduce oxidative damage.

show abstract

“…Inflammation is a set of processes causing by different types and levels of cytokines, growth factors, NO, and prostaglandins, which are produced by activated macrophages and other immune system cells (Askari, Baradaran Rahimi, et al, ; Askari, Rahimi, et al, ; Askari & Shafiee‐Nick, ; Kianmehr et al, ; Rahimi et al, ; Rahimi, Askari, Shirazinia, et al, ). In this section, the antiinflammatory effects of pomegranate and EA and their possible mechanisms have been discussed by details.…”

Section: Resultsmentioning

confidence: 99%

“…Inflammation is commonly characterized as a defensive and protective reaction of the body against various exogenous or endogenous stimuli, which aims to maintain the body health. On the other hand, chronic inflammation may cause inflammatory disorders and pain through the secretion of inflammatory mediators including prostaglandins, nitric oxide (NO), interferon gamma (IFN‐γ) and histamine (Askari et al, ; Askari, Alavinezhad, & Boskabady, ; Askari, Baradaran Rahimi, Rezaee, & Boskabady, ; Askari, Rezaee, Abnous, Iranshahi, & Boskabady, ; Askari & Shafiee‐Nick, ; Rahimi et al, ; Rahimi et al, ; Rahimi, Askari, & Mousavi, ).…”

Section: Introductionmentioning

confidence: 99%

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

Self Cite

123

View full text Add to dashboard Cite

Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T‐cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.

show abstract

Comparison of honey and dextrose solution on post-operative peritoneal adhesion in rat model

Cited by 57 publications

References 60 publications

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

Surgery-Induced Changes in Erythrocyte and Plasma Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidants of Female Rats: Protective Role of Heparin and Pentoxifylline

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Contact Info

Product

Resources

About