Comparison of histopathologic risk factors in enucleated eyes with retinoblastoma treated with chemoreduction versus no therapy

Taçyıldız, Nurdan; Özdemir, Haşan; Yavuz, Günay Yapıcı; Ünal, Emel; Ergun, Hikmet Nese; Erden, Esra; Dinçaslan, Handan; Heper, Aylın Okçu; Günduz, Kaan

doi:10.1200/jco.2008.26.15_suppl.10039

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of scleral invasion is unusual for uveal schwannomas: Of the 52 cases in the COPLOW collection, only six (11.5%) present scleral invasion in the sections sampled. Scleral invasion is recognized as a negative prognostic indicator and a histologic metric for metastatic risk in human retinoblastomas and melanomas . Intraocular schwannomas in humans are rare, and none have been reported to metastasize.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic uveal schwannoma of blue‐eyed dogs

Duke

Brudenall²,

Scott

et al. 2013

Veterinary Ophthalmology

View full text Add to dashboard Cite

A formalin-fixed left, blue eye, from a 9-year-old, spayed female beagle dog was submitted to the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) for light microscopic evaluation. The history included glaucoma and an abnormal appearance for 6 months and then the development of a uveal mass. The histologic diagnosis was a spindle cell tumor of blue-eyed dogs (SCTBED). In June of 2012, the dog was euthanized due to ailing health, and there was radiographic and postmortem examination evidence of neoplastic metastasis. This is the first reported case of this primary ocular neoplasm metastasizing, and we propose to rename SCTBED as a uveal schwannoma of blue-eyed dogs.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Scleral invasion is recognized as a negative prognostic indicator and a histologic metric for metastatic risk in human retinoblastomas and melanomas. 7,8 Intraocular schwannomas in humans are rare, and none have been reported to metastasize. The cell of origin is immunohistochemically confirmed in these cases by vimentin and S100 positivity.…”

Section: Discussionmentioning

confidence: 99%