Comparison of histologic types of primary testicular germ cell tumors with their metastases

Bär, W.; Hedinger, Chr.

doi:10.1007/bf00427309

Cited by 48 publications

(6 citation statements)

References 13 publications

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“…Histological features that are helpful for establishing a diagnosis of a burned-out testicular germ cell tumor include scar formation, intratubular calcifications, lymphoplasmacytic infiltrate, hemosiderin-containing macrophages and testicular atrophy (9). Scrotal sonography has been reported to be a relatively useful diagnostic tool for burned-out tumors.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Metastatic Choriocarcinoma from a Burned-out Testicular Tumor

et al. 2016

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A 54-year-old man was referred to our hospital because of progressive dyspnea. Chest computed tomography showed multiple nodular shadows with a peripheral ground-glass halo. His clinical condition continued to deteriorate with the development of progressive respiratory failure requiring mechanical ventilation. A histological examination of a transbronchial lung biopsy revealed choriocarcinoma. The patient died within nine days of admission. A histological examination of the right testis during an autopsy revealed a burned-out testicular tumor consisting of a teratoma and a fibrous scar. We herein report a rare case of pulmonary multiple metastatic choriocarcinoma originating from a burned-out testicular tumor.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Metastatic Choriocarcinoma from a Burned-out Testicular Tumor

et al. 2016

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“…In an autopsy study, about 10% of patients who died of metastatic testicular germ cell tumors had such 'burnt-out' primary tumors. 130 Features that are helpful in establishing a diagnosis of a regressed testicular germ cell tumor include, apart from the scar formation, intratubular calcifications, IGCNU, a lymphoplasmacytic infiltrate, hemosiderin-containing macrophages, and testicular atrophy ( Figure 22). [130][131][132] In many cases, the scarred focus still has residual, hyalinized tubular outlines, which therefore should not be misconstrued as evidence for a non-neoplastic scarring process.…”

Section: Regression Of Primitive Germ Cell Tumorsmentioning

confidence: 99%

“…130 Features that are helpful in establishing a diagnosis of a regressed testicular germ cell tumor include, apart from the scar formation, intratubular calcifications, IGCNU, a lymphoplasmacytic infiltrate, hemosiderin-containing macrophages, and testicular atrophy ( Figure 22). [130][131][132] In many cases, the scarred focus still has residual, hyalinized tubular outlines, which therefore should not be misconstrued as evidence for a non-neoplastic scarring process. It is likely that such tubular remnants within scars reflect regression of intertubular growth of pre-existing germ cell tumor, a relatively frequent focal pattern in seminoma.…”

Section: Regression Of Primitive Germ Cell Tumorsmentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

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“…In a retrospective review of cases, there are areas of fibrosis, hemosiderophages, chronic inflammatory cells, and often microcalcifications associated with IGCN. 33 Chromosomal abnormalities typically associated with germ cell tumors have been identified in the teratomas with secondary malignant transformation, although the phenotype of these neoplasms is completely different from the germ cell line. Motzer performed cytogenetic studies in somatic tumors arising in germ cell tumors and found isochromosome 12p in 10 cases and deletion of chromosome 12p in one case.…”

Section: Discussionmentioning

confidence: 99%