Comparison of High-sensitivity C-reactive Protein Level  between Chronic Kidney Disease Stages

Thaha, Mochammad; Imro'ati, Tri Asih; Wardana, Aditia; Widodo, Widodo; Pranawa, Pranawa; Irwanadi, Chandra

doi:10.20473/bhsj.v1i1.8226

Cited by 5 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was explained with the small sample of 72 subjects. 31 The latest research by a group of Chinese authors showed that long-term exposure to high CRP values was associated with an increased risk of developing CKD. 32 NLR is a cheap, routinely used, and repeatable test, and many studies have found that it can be an indicator of systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Klapuh-Bukvić

Serdarevic

Uncanin

et al. 2022

Journal of Interdisciplinary Medicine

View full text Add to dashboard Cite

Background: Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD). Aim: To determine the values of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with different stages of CKD and to examine how they change depending on the progression of renal damage. Materials and methods: A cross-sectional descriptive comparative study included 157 subjects at different stages of CKD which was assessed based on glomerular filtration rate (GFR) calculated according to the MDRD equation. CRP was analyzed by an immunoturbidimetric method. NLR and PLR were calculated by a mathematical calculation after a blood count was performed. Results: The present study showed an increase in serum creatinine, CRP, and NLR values with progression of renal failure. There was a statistically significant difference in the creatinine and CRP concentrations between groups with different stages of CKD (p <0.001 for all comparisons). A significant positive correlation was found between NLR and CRP, while negative, significant correlations were observed between NLR and eGFR as well as between PLR and eGFR. There was a slight increase in PLR value with the progression of renal impairment, but the correlation between PLR and CRP was not significant. Conclusion: These results suggest that NLR, together with CRP, may serve as an indicator of systemic low-grade inflammation progression in patients with CKD. Larger prospective studies are required to observe the possibility of using NLR as a surrogate marker for CRP in patients with CKD.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Klapuh-Bukvić

Serdarevic

Uncanin

et al. 2022

Journal of Interdisciplinary Medicine

View full text Add to dashboard Cite

show abstract

“…Progressive renal impairment is associated with worsening systemic inflammation and elevated levels of C-Reactive Protein (CRP) detected along with other acute-phase proteins. Monitoring CRP levels in CKD patients, especially in the late stage, has been implemented because CRP is an inflammatory marker which has a stable condition and does not 5,6 show significant circadian variability.…”

Section: Metana Puspitasari MI Diah Pramudianti Yuwono Hadisupartomentioning

confidence: 99%

Relationship between High Sensitivity C-Reactive Protein and Total Testosterone Levels in Male Patients with Stage V Chronic Kidney Disease

Puspitasari¹,

Pramudianti²,

Hadisuparto³

2022

Indonesian J. Clin. Pathol. Med. Lab.

View full text Add to dashboard Cite

The incidence of decreased total testosterone level increases in stage V CKD patients. Decreased total testosterone levels is influenced by uremia and hemodialysis bioincompatibility through an increase in the inflammatory mediator hs-CRP. Obesity and age are risk factors of CKD incidence which can directly affect testosterone level. This study aimed to analyze the relationship between hs-CRP, serum urea, age, obesity, and hemodialysis duration with decreased total testosterone levels in stage V CKD patients. This observational study with cross-sectional approach was performed are 60 stage V CKD patients treated in Dr. Moewardi General Hospital, Surakarta on November 2020. The data were analyzed with 2x2 table test, followed by multivariate analysis using logistic regression. The examinations of total testosterone and hsRP used ECLIA and immunoturbidimetric assay, respectively. This study obtained 21 (37%) study who experienced a decreased total testosterone level (<3ng/mL). hs-CRP level [PR 3.656 (95% CI: 1.202-11,124; p=0.020)]; obesity [PR 4.156 (95% CI: 1.272-13.581; p=0.015)] and urea [PR 4.474 (95% CI: 1.273-15.728; p=0.015)] significantly associated with decreased total testosterone level of <3 ng/ml. Meanwhile age was not statistically significant (p=0.694) and hemodialysis duration obtained PR <1 and CI 95% < 1 (p=0.018). Therefore in patients with stage V, hs-CRP levels â‰¥ 0.65 mg/dl, serum urea â‰¥ 120 mg/dL, and obesity correlate with decreased total testosterone level while age is not associated with decreased total testosterone level. The hemodialysis duration is not a risk factor of decreased total testosterone.

show abstract

“…Hematological investigations, especially full blood counts, are good indicators in health and disease states, helping to understand the real disease presentation juxtaposed to the features in the patients (George et al, 2015). This study showed decrease in Hb, PCV and RBC in HD patients compared with diabetic patients and control; this decrease is due to hematuria and gastrointestinal blood loss or due to a decrease in the production of erythropoietin by the kidney, leading to decreased production of RBC in the bone marrow, and anemia that causes hypoxia; Hypoxia will increase hepsidin that causes functional iron deficiency through inhibition of iron absorption in the intestine and inhibition of Fe distribution in blood circulation as more is stored in macrophages or spleen (Abd Rabo et al,2016, Thaha et al, 2018.…”

Section: Human High Sensitivity C-reactive Protein (Hs-crp) Level In Four Study Groupsmentioning

confidence: 99%

Correlation of Chemerin with some Immunological Parameters in Type II Diabetes Mellitus Patients on Hemodialysis in Ramadi General Hospital

2021

JJBS

View full text Add to dashboard Cite

Diseases of kidney are among the most important causes of death in many countries. The major causes of chronic kidney disease include diabetes mellitus and chronic hypertension. This study was designed to evaluate some hematological and inflammation aspects in 95 patients, divided into (35) hemodialysis patients with diabetes, (35) hemodialysis patients without diabetes and (25) diabetes patients, and who attended at Ramadi General Hospital, in addition to (25) samples as control subject. Chemerin, Interleukin-18 (IL-18) and high sensitive C-reactive protein (hs-CRP) were established by ELISA. The results showed serum chemerin, interleukin-18 and hs-CRP were significantly higher in HD patients with diabetes (230.13±78.26 ng/ml at P=0.034, 677.23±99.14 pg/mL at P=0.026, and 15.77±2mg/L at P=0.048), respectively compared with control (110±20.42ng/ml, 143.68±35.78pg/mL, and 4.64±1.27mg/L), respectively. The results showed the significant and positive correlations between chemerin and hs-CRP or chemerin and IL-18 (r=0.149 at P=0.004 or r=0.123 at P=0.0325 in control), (r=0.165 at P=0.007 or r =0.190 at P=0.024 in diabetic patients), (r=0. 237 at P=0.0036 or r =0.263 at P= 0.038 in HD patients with diabetic) and (r=0. 0.235 at P = 0.0081or r=0.248 at P = 0.041in HD patients without diabetic) respectively. The mean of hemoglobin (Hb), Packed Cells Volume (PCV), Red Blood cells (RBC), White Blood Cells (WBC) and Lymphocytes were significantly decreased in HD patients without diabetes (8.55±0.63g/L (at p=0.0423), 27.63±1.31%(at p=0.028), 3.12±0.56 ˟10P 12 P \ L (at p=0.035), 6.7±0.53 ˟10P 9 P /L (at p=0.021) and 30.23±5.84%(at p= 0.046), respectively compared with control. The mean of Monocytes% (17.23±7.28% at p=0.031) and Granulocyte% (59.31±9.45 % at p=0.042) were significantly higher in HD patients with diabetes, while mean of Mononocytes% was significant lower in diabetic patients. This study suggests a significant role of chemerin, hs-CRP and IL-18 in the pathogenesis and progression of diabetic complications, and we can use these parameters for predicting the progression of diabetic nephropathy in the early stages of CKD.

show abstract

Comparison of High-sensitivity C-reactive Protein Level between Chronic Kidney Disease Stages

Cited by 5 publications

References 24 publications

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Relationship between High Sensitivity C-Reactive Protein and Total Testosterone Levels in Male Patients with Stage V Chronic Kidney Disease

Correlation of Chemerin with some Immunological Parameters in Type II Diabetes Mellitus Patients on Hemodialysis in Ramadi General Hospital

Contact Info

Product

Resources

About