Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism

Bilgir, Oktay; Bilgir, Ferda; Topçuoğlu, Tuba; Çalan, Mehmet; Çalan, Özlem Gürsoy

doi:10.1007/s12020-013-9993-z

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Two studies evaluated CRP levels in SH subjects and both reported no change in CRP levels compared to euthyroid group [11,12]. Bilgir et al also evaluated CRP levels 3 months after treatment with propyl thiouracil and reported no significant change in CRP levels after using anti-thyroid drug [11]. In our study, we also found no significant change in CRP levels after carbimazole suggesting absence of inflammatory state in SH.…”

Section: Discussionsupporting

confidence: 49%

“…Only one study reported higher CRP in 250 hyperthyroid subjects compared to controls but the same study reported much higher CRP levels in hypothyroid subjects [10]. Two studies evaluated CRP levels in SH subjects and both reported no change in CRP levels compared to euthyroid group [11,12]. Bilgir et al also evaluated CRP levels 3 months after treatment with propyl thiouracil and reported no significant change in CRP levels after using anti-thyroid drug [11].…”

Section: Discussionmentioning

confidence: 99%

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The Role of Inflammation in Contributing to Vascular Risk in Subclinical Hyperthyroidism: Randomized Controlled Trial

et al. 2021

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Background: Subclinical hyperthyroidism (SH, defined by low or undetectable serum thyroid stimulating hormone and normal thyroid hormones) is associated with increased cardiovascular risk (CVR) such as atrial fibrillation. Few studies also showed an increased risk of vascular disease and mortality in SH. Inflammation has been shown to play a significant role in the pathogenesis of cardiovascular disease. Increased levels of C-reactive protein (CRP), lipoprotein associated phospholipase A2 (Lp-PLA2, an inflammatory marker which plays a critical role in atherosclerosis), neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) have been reported in conditions with increased cardiovascular risk. We aimed to ascertain whether abnormal CRP, Lp-PLA2, NLR and MLR contribute to an increased CVR in SH. Methods: CRP, Lp-PLA2, NLR and MLR in peripheral blood were measured in 30 SH subjects at baseline and after 6 months of treatment with either carbimazole or placebo in a randomized placebocontrolled design. Results: There was no significant difference in CRP, Lp-PLA2, NLR and MLR between carbimazole and placebo treated groups at 6 months. There was also no statistical difference in the above parameters if we compared the change or difference between two visits (visit 2 and visit 0 levels) in both groups. Conclusion: There is no evidence of chronic inflammation in our small cohort of SH subjects. Our finding needs to be confirmed in future studies with larger number of SH subjects.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

The Role of Inflammation in Contributing to Vascular Risk in Subclinical Hyperthyroidism: Randomized Controlled Trial

et al. 2021

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“…Fetuin-A (α-Heremans-Schmid glycoprotein) is a circulating glycoprotein secreted by the liver into the circulation. Links between fetuin-A and cardiovascular disease, insulin resistance, diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver have been reported ( 15 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism

Bilgir¹,

Bilgir²,

Çalan³

et al. 2015

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OBJECTIVE:The objective of this trial was to determine the levels of inflammatory markers, high-sensitivity C-reactive protein and fetuin-A pre- and post-levothyroxine treatment in cases of subclinical hypothyroidism.MATERIALS AND METHODS:A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for high-sensitivity C-reactive protein and fetuin-A, followed by the administration of 50 µg of levothyroxine in the patient group for 3 months. During the post-treatment stage, high-sensitivity C-reactive protein and fetuin-A levels in the patient group were re-assessed and compared with pre-treatment values.RESULTS:Pre-treatment levels of both high-sensitivity C-reactive protein and fetuin-A were observed to be higher in the patient group than in the control group. The decrease in high-sensitivity C-reactive protein levels during the post-treatment stage was not statistically significant. However, the decrease observed in post-treatment fetuin-A levels was found to be statistically significant.CONCLUSION:The decrease in fetuin-A levels in subclinical hypothyroidism cases indicates that levothyroxine treatment exerts anti-inflammatory and anti-apoptotic effects. Although the decrease in high-sensitivity C-reactive protein levels was statistically non-significant, it is predicted to reach significance with sustained treatment.

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“…While an increase in fibrinogen concentration was reported in several studies, Hp concentration, the ESR and CRP (a major acute phase reactant in humans) were not significantly different between hyperthyroid and euthyroid patients. [24][25][26][27][28] The same appears to be true for cats. As demonstrated here, hyperthyroidism induced an increase in AGP concentration and, to a lesser extent, in SAA and Hp concentrations.…”

Section: Discussionmentioning

confidence: 80%

Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats

Glück

Mohrs

Hazuchova

et al. 2021

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats. Methods Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Immediately before, and 12, 36, 72 h and 6 days after RIT, serum samples were obtained for determination of APP concentrations. Results Both SAA and AGP concentrations changed significantly after RIT. The concentration of AGP increased gradually after treatment with a maximum concentration at the end of the study period (median baseline 398 μg/ml; median 6 days post-RIT 562 μg/ml [ P = 0.001]). A relevant >two-fold increase in AGP was seen in 8/33 (24%) cats. SAA concentration increased significantly within 12 h (baseline 9.2 μg/ml; 12 h post-RIT 22.5 μg/ml [ P = 0.012]). In 7/33 (21%) cats, a clinically relevant >10-fold increase in SAA was observed. Hp concentration showed no significant change ( P = 0.12). Conclusions and relevance RIT induced a mild, mainly not clinically relevant acute phase reaction (APR). AGP and SAA were useful APPs to determine RIT-induced APR.

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Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism

Cited by 6 publications

References 31 publications

The Role of Inflammation in Contributing to Vascular Risk in Subclinical Hyperthyroidism: Randomized Controlled Trial

The Role of Inflammation in Contributing to Vascular Risk in Subclinical Hyperthyroidism: Randomized Controlled Trial

Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism

Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats

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