Comparison of high-performance liquid chromatography and capillary zone electrophoresis in penciclovir biodegradation kinetic studies

Development and validation of a new reversed-phase ion pairing liquid chromatographic method with fluorescence detection for penciclovir analysis in plasma and aqueous humor

“…triethylamine) in the mobile phase has been used to increase their retention in reversed phase chromatography [9]. Penciclovir has also been analysed with capillary electrophoresis (CE) coupled with an UV detection [13]. However, in spite of its high selectivity, efficiency and fast separation time, this technique suffers from low sensitivity.…”

Validated spectrometric determination of penciclovir and entecavir in bulk and in pharmaceutical preparations

“…4,5 A detailed survey of analytical literature of PCV revealed several methods based on various techniques, HPLC using UV 6,7 fluorescence [8][9][10][11] and mass spectrometry 12,13 as detectors and capillary zone electrophoresis. 14 Besides, different analytical methods for the determination of ETV have been reported, including UV-spectrophotometry, 15,16 HPLC using UV [17][18][19] and mass spectrometry [20][21][22][23][24] as detectors, and capillary zone electrophoresis. 25 Accordingly, the literature revealed that there is no reported spectrofluorimetric method for the determination of PCV or ETV although they have native fluorescence which represents a direct method for the determination of the two drugs.…”

Simultaneous determination of aciclovir, ganciclovir, and penciclovir in human plasma by high-performance liquid chromatography with fluorescence detection

“…Hence, this complicates analysis and requires using a highly selective analytical method. Some analytical methods have been proposed for individual measurement of ACV [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], GCV [38][39][40][41][42][43][44][45], and PCV [46][47][48]. Other techniques have been developed for simultaneous determination of ACV and GCV [49][50][51], valacyclovir and ACV [52], or valganciclovir, and GCV [53], through high-performance liquid chromatography (HPLC) in biological fluids.…”