Comparison of High-Frequency and MIST Ultrasound Therapy for the Healing of Venous Leg Ulcers

Beheshti, Akram; Shafigh, Younes; Parsa, Hossien; Zangivand, Amir Abdollah

doi:10.17219/acem/37353

Cited by 15 publications

(20 citation statements)

References 11 publications

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“…Similar studies have also been conducted by Beheshti et al [ 5 ]. Ninety patients with venous leg ulcers were divided equally into three groups.…”

Section: Discussionsupporting

confidence: 84%

“…A literature review shows that the mean percentage reduction of ulceration area was higher when noncreative low frequency ultrasound therapy was used than high frequency ultrasound therapy [ 4 , 5 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mean percentage reduction of the ulcer treated with noncreative low frequency ultrasound therapy ranged from 45% (after 4 weeks of treatment) to 73% (after 12 weeks of treatment) [ 2 , 6 ]. When high frequency ultrasound therapy was used, the mean percentage reduction of the area of ulceration was noted from 57% (after 7 weeks of treatment) to 67% (after 12 weeks of treatment) [ 4 , 5 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of ultrasound therapy and radial shock wave therapy in the treatment of venous leg ulcers – clinical, pilot study

Dolibog¹,

Dolibog²,

Franek³

et al. 2018

pdia

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IntroductionVenous insufficiency and venous leg ulcers each year affect more and more people, especially in developed countries. The challenge of our time is to find an effective method of treating venous leg ulcers, which will further shorten treatment time and reduce the cost of treatment.AimTo compare the effects of treating venous leg ulcers using ultrasound therapy, radial shock wave therapy and standard care.Material and methodsGroup A consisted of 17 patients. Patients were treated with ultrasound therapy US power density 0.5 W/cm2, pulsed wave with a duty cycle of 1/5, and 1 MHz frequency. Group B consisted of 17 patients. Patients were treated with the radial shock wave R-ESWT using surface energy density 0.17 mJ/mm2, 100 impulses/cm2, frequency of 5 Hz and a pressure of 0.2 MPa. Group C (control group) consisted of 17 patients. Patients in this group received standard care: gauze dressing saturated in 0.9% sodium chloride and elastic bandages changed daily for 4 weeks.ResultsUltrasound therapy with 1 MHz and energy power density 0.5 W/cm2 for 4 weeks resulted in an average reduction of 68% of the area of ulceration. We used for venous leg ulcers 4-week treatment with radial shock wave therapy resulting in a 38% mean percentage reduction of the ulceration area. Standard care reduces the area of ulceration by only 16%.ConclusionsThe use of ultrasound therapy for the treatment of venous leg ulcers is more effective than the use of radial shock wave therapy or standard care alone.

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“…Similar studies have also been conducted by Beheshti et al [ 5 ]. Ninety patients with venous leg ulcers were divided equally into three groups.…”

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of ultrasound therapy and radial shock wave therapy in the treatment of venous leg ulcers – clinical, pilot study

Dolibog¹,

Dolibog²,

Franek³

et al. 2018

pdia

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“…The same search, as previously described, allowed us to retrieve nine publications reporting on time to wound closure (either mean or median) varying from 5 to 6 weeks up to 1 year. 32,36,40,53,[57][58][59][60][61] The BioPhotonic System performed well when compared with other treatments in terms of closure rates and time to wound closure. Furthermore, its treatment regimen led to a high rate of compliance.…”

Section: Discussionmentioning

confidence: 99%

A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers

Nikolis¹,

Grimard²,

Pesant³

et al. 2016

CWCMR

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Purpose: To investigate the safety and efficacy of the BioPhotonic System developed by Klox Technologies in a case series of ten patients with venous leg ulcers. Patients and methods: Ten patients with chronic venous leg ulcers, having failed on at least one previous therapy, were enrolled into this case series. Results: Nine patients were evaluable for efficacy. A response (defined as decrease in wound surface area) was observed in seven patients (77.8%). Of these, four patients (44.4%) achieved wound closure on average 4 months (127.5 days) following the beginning of the treatment. Two patients did not respond to the investigational treatment. Quality of life improved over time throughout the study. Compliance was excellent, with 93.2% of visits completed as per protocol. Safety was unremarkable, with only four treatment-emergent-related adverse events, for which no specific intervention was required. Conclusion: The BioPhotonic System was shown to be safe and extremely well tolerated. It also demonstrated potential in terms of wound closure, wound surface area decrease, and wound bed preparation.

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“…The use of low-frequency ultrasound has been explored in 10 published randomized controlled trials (RCTs) [23][24][25][26][27][28][29][30][31][32] as well as numerous case reports and observational cohort series. The most widely used method, MIST Therapy System (Celleration Inc), delivers a noncontact low-frequency (NCLF, 40 kHz), low-intensity (0.2-0.6 W/cm 2 ) ultrasound energy to the wound bed through a fine mist of sterile saline delivered at a distance between 5 and 15 mm from the wound.…”

Section: Low-frequency Ultrasound Debridementmentioning

confidence: 99%

Ultrasound Devices to Treat Chronic Wounds: The Current Level of Evidence

Kotronis

Vas

2020

The International Journal of Lower Extremity Wounds

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Chronic wounds cause considerable morbidity and utilize significant health care resources. In addition to addressing wound etiology and treating infection, regular debridement is a key component of wound care with a proven ability to accelerate healing. In this regard, a significant innovation in wound care has been the development of ultrasound debridement technology. The purpose of this review is to evaluate the current evidence behind the technology with an emphasis on noncontact low-frequency (NCLF) ultrasound. A number of studies, especially those evaluating NCLF technology, have demonstrated the potential of ultrasound debridement to effectively remove devitalized tissue, control bioburden, alleviate pain, and expedite healing. However, most of the studies are underpowered, involve heterogeneous ulcer types, and demonstrate significant methodological limitations making comparison between studies difficult; there is a paucity of data on cost-effectiveness. Future clinical trials on ultrasound debridement technology must address the design issues prevalent in current studies, and report on clinically relevant endpoints before adoption into best-practice algorithms can be recommended.

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Comparison of High-Frequency and MIST Ultrasound Therapy for the Healing of Venous Leg Ulcers

Cited by 15 publications

References 11 publications

Comparison of ultrasound therapy and radial shock wave therapy in the treatment of venous leg ulcers – clinical, pilot study

Comparison of ultrasound therapy and radial shock wave therapy in the treatment of venous leg ulcers – clinical, pilot study

A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers

Ultrasound Devices to Treat Chronic Wounds: The Current Level of Evidence

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