Comparison of HER2 status of breast cancer between Chinese women in China and Chinese-American women in the US

Yang, Yi; Qian, Xiao Long; Fu, Li

doi:10.1111/tbj.12921

Cited by 1 publication

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References 6 publications

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“…Approximately 1.68 million women are diagnosed with BC worldwide each year and it ranks as the leading cause of cancer-associated cases of mortality in women (1). Although China is a country with a lower incidence of BC, incidence and mortality still ranks the highest for BC in female malignant cancer types (2–4). BC is a heterogeneous disease that exhibits high sensitivity to chemotherapeutic treatment; approximately 50% of patients with advanced breast cancer benefit from combined chemotherapy, whereas the other half experience only the adverse effects from chemotherapy drugs (5).…”

Section: Introductionmentioning

confidence: 99%

Sperm‑associated antigen 5 is a potential biomarker for poor prognosis in breast cancer

et al. 2018

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Sperm-associated antigen 5 (SPAG5) is currently considered to serve a role in promoting tumor cell growth and is overexpressed in several types of human cancer. However, to the best of our knowledge, the association of SPAG5 with molecular subtypes of patients with breast cancer (BC) remains to be fully investigated. Reverse transcription-quantitative polymerase chain reaction and immunohistochemistry on tissue microarrays were used in the current study to detect the expression levels of SPAG5 mRNA and protein, respectively, in BC. The association between SPAG5 mRNA and protein levels, and clinical characteristics and prognostic information were investigated. SPAG5 mRNA and protein levels were identified to be higher in BC tissues compared with matched adjacent nontumor tissues. High expression level of SPAG5 protein was associated with tumor size, histological grade, estrogen receptor expression, Ki-67 expression, lymph node status, tumor-node-metastasis (TNM) stage and the triple-negative BC subtype. In addition, high expression level of SPAG5 protein was associated with a poor prognosis in patients with BC. In summary, the current study suggests that SPAG5 is a novel and useful prognostic biomarker in BC.

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