Comparison of hepatic properties and transplantation of Thy-1<sup>+</sup>and Thy-1<sup>−</sup>cells isolated from embryonic day 14 rat fetal liver

Oertel, Michael; Menthena, Anuradha; Chen, Yuanqing; Shafritz, David A.

doi:10.1002/hep.21775

Cited by 30 publications

(17 citation statements)

References 53 publications

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“…34,35 Thy-1 ϩ mesenchymal cells were also identified in rat fetal liver 36 and it was reported that they support hepatic progenitor cell maturation in the mouse fetal liver. 37,38 Our studies show that Thy-1-expressing cells in rat liver are a heterogeneous population.…”

Section: Discussionmentioning

confidence: 96%

Thymus cell antigen-1-expressing cells in the oval cell compartment

et al. 2009

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O ver the years, substantial evidence has accumulated demonstrating the existence of adult hepatic progenitor cells, also termed oval cells (OCs). When the regenerative capacity of terminally differentiated hepatocytes is exhausted or blocked, these cells are activated to proliferate and differentiate into hepatocytes and cholangiocytes. OCs sprout from the putative stem cell niche (canals of Hering), forming tortuous pseudoducts and invading the liver lobule. 1-6 These pseudoducts are in close proximity to desmin-positive stellate cells. 7 Recently, we found a population of activated mesenchymal cells, thymus cell antigen-1 (Thy-1)-expressing cells, surrounding OCs. These cells partially overlapped with the desmin-positive cells and produce inductive signals (growth factors and cytokines) in the OC niche. 8,9 Thy-1 is a cell surface glycophosphatidylinositollinked glycoprotein with a molecular mass of 35 kDa and is an adhesion molecule of the immunoglobulin super-

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Section: Discussionmentioning

confidence: 96%

Thymus cell antigen-1-expressing cells in the oval cell compartment

et al. 2009

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“…The transplanted progenitor cells, which repopulated about 23.5% of the total hepatic cell mass and exhibited a greater proliferative activity and a lower rate of apoptotic death relative to host hepatocytes, shown a longterm liver replacement at 6 months after cell transplantation [201]. In regard with this, it has also been noticed that the Thy-1 − stem/progenitor cells expressing -fetoprotein, albumin, CK19, E-cadherin and CXCR4 isolated from embryonic day 14 rat fetal liver substantially repopulated normal adult rat liver and totally repopulated retrorsine-treated rat liver while the Thy-1 + /CD45 + /CXCR4 + subpopulation was only incorporated after severe hepatic injury [202]. This suggests then that fetal Thy-1 − liver progenitor cells may represent a most immature progenitor cell population than Thy-1 + counterpart with distinct regenerative properties [202].…”

Section: Hepatic Oval Cells and Their Therapeutic Applicationsmentioning

confidence: 87%

“…In regard with this, it has also been noticed that the Thy-1 − stem/progenitor cells expressing -fetoprotein, albumin, CK19, E-cadherin and CXCR4 isolated from embryonic day 14 rat fetal liver substantially repopulated normal adult rat liver and totally repopulated retrorsine-treated rat liver while the Thy-1 + /CD45 + /CXCR4 + subpopulation was only incorporated after severe hepatic injury [202]. This suggests then that fetal Thy-1 − liver progenitor cells may represent a most immature progenitor cell population than Thy-1 + counterpart with distinct regenerative properties [202]. In support with this, a recent study has revealed that Thy-1 expression was induced during transit-amplification process of the oval cell population while Thy-1 mRNA was undetectable in the -fetoprotein-expressing oval cells during liver regeneration after tissue injury in animal models and patients with liver failure [203].…”

Section: Hepatic Oval Cells and Their Therapeutic Applicationsmentioning

confidence: 94%

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

2008

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Recent progress in the field of the stem cell research has given new hopes to treat and even cure diverse degenerative disorders and incurable diseases in human. Particularly, the identification of a rare population of adult stem cells in the most tissues/organs in human has emerged as an attractive source of multipotent stem/progenitor cells for cell replacement-based therapies and tissue engineering in regenerative medicine. The tissue-resident adult stem/progenitor cells offer the possibility to stimulate their in vivo differentiation or to use their ex vivo expanded progenies for cell replacement-based therapies with multiple applications in human. Among the human diseases that could be treated by the stem cell-based therapies, there are hematopoietic and immune disorders, multiple degenerative disorders, such as Parkinson's and Alzeimeher's diseases, type 1 or 2 diabetes mellitus as well as eye, liver, lung, skin and cardiovascular disorders and aggressive and metastatic cancers. In addition, the genetically-modified adult stem/progenitor cells could also be used as delivery system for expressing the therapeutic molecules in specific damaged areas of different tissues. Recent advances in cancer stem/progenitor cell research also offer the possibility to targeting these undifferentiated and malignant cells that provide critical functions in cancer initiation and progression and disease relapse for treating the patients diagnosed with the advanced and metastatic cancers which remain incurable in the clinics with the current therapies.

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“…Hepatoblasts are considered a heterogeneous population with potential hierarchical organization and various degrees of differentiation (113). Therefore, many controversial issues including differentiation status and the repopulation capability of markerpositive hepatoblasts have been raised, even using robust stem cell markers (95,114,115). Similarly, liver CSCs are considered highly heterogeneous and may show distinct phenotypes in terms of tumorigenic/metastatic features and chemosensitivity when purified using different CSC markers (116).…”

Section: Shared Features Of Liver Development and Liver Cancer Develomentioning

confidence: 99%

Cancer stem cells in the development of liver cancer

Yamashita

Wang²

2013

J. Clin. Invest.

464

431

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Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor markers are useful for isolating a subset of liver cells with stem cell features, known as cancer stem cells (CSCs). These cells are responsible for tumor relapse, metastasis, and chemoresistance. Liver CSCs dictate a hierarchical organization that is shared in both organogenesis and tumorigenesis. An increased understanding of the molecular signaling events that regulate cellular hierarchy and stemness, and success in defining key CSC-specific genes, have opened up new avenues to accelerate the development of novel diagnostic and treatment strategies. This Review highlights recent advances in understanding the pathogenesis of liver CSCs and discusses unanswered questions about the concept of liver CSCs.

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Comparison of hepatic properties and transplantation of Thy-1⁺and Thy-1⁻cells isolated from embryonic day 14 rat fetal liver

Cited by 30 publications

References 53 publications

Thymus cell antigen-1-expressing cells in the oval cell compartment

Thymus cell antigen-1-expressing cells in the oval cell compartment

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

Cancer stem cells in the development of liver cancer

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Comparison of hepatic properties and transplantation of Thy-1+and Thy-1−cells isolated from embryonic day 14 rat fetal liver

Cited by 30 publications

References 53 publications

Thymus cell antigen-1-expressing cells in the oval cell compartment

Thymus cell antigen-1-expressing cells in the oval cell compartment

Recent Progress on Tissue-Resident Adult Stem Cell Biology and Their Therapeutic Implications

Cancer stem cells in the development of liver cancer

Contact Info

Product

Resources

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Comparison of hepatic properties and transplantation of Thy-1⁺and Thy-1⁻cells isolated from embryonic day 14 rat fetal liver