Comparison of Hemolytic Properties of Different Shapes of Occlusion of Blood Sac in Occlusive‐type Pulsatile Blood Pump

Abstract

The occlusive-type pulsatile extracorporeal blood pump (T-PLS, Seoul National University, Seoul, Korea) received the Communauté Européenne mark of the European Directives (2003) and Korea Food and Drug Administration approval (2004) for short-term application as an extracorporeal life support system. The pump system was recently upgraded in the ameliorated actuator head for reducing hemolysis, rather than in the existing actuator head. In this study, the hemolytic performance of the new pump system (assessed as the degree of occlusiveness of the blood sac) was compared with the existing one. A roller pump, the Stockert S3 (Stockert Instrumente GmbH, Munchen, Germany), was selected as a control device. Five tests were conducted for each pump, with each of these tests lasting for 6 h. A pump flow of 3 L/min with 50 beats per minute was included in the hemolytic test conditions. The lowest hemolytic results were obtained by the new pump system yielding a normalized index of hemolysis of less than 0.005 g/100 L, and this result was one-fourth that of the roller pump, Stockert S3.

Optimal Moving Angle of Pusher Plate in Occlusive‐Type Pulsatile Blood Pump

“…A simulation was performed using the commercial package, LS‐DYNA (Livermore Software Technology Cooperation, Livermore, CA, USA) (4). In the previous article, the hemolysis results of two different pusher plates (fixed type, roller type) were compared (1). However, in this study, only one pusher plate, the roller type that showed better hemolysis results in a previous study, was used and blood flow analysis was not considered as hemolysis or flow pattern.…”

“…In a previous study, we presented an important parameter that affects hemolysis with occlusive pumps—the shape of the occlusion (folding pattern) of the blood sac (1). The Twin‐Pulse Life Support System (T‐PLS; Seoul National University and Korea University, Seoul, Korea) is a pulsatile extracorporeal life support system that was developed in Korea (2).…”

“…Since the T‐PLS was developed, hemolysis testing with different folding patterns of blood sac has been carried out. However, only two folding patterns which are extremely different were tested (1). As the degree of occlusiveness of the blood sac is increased by the angle of the pusher plate, hemolysis occurs as a result of the rupture of red blood cells.…”

“…This system has an angle of pusher plate movement (PPM) (Fig. 1), not a straight back‐and‐forth motion, which has been responsible for the better results of hemolysis with a roller‐type pusher plate (1). In this point of view, determining the optimal angle of the PPM of the roller for the lowest stress on the blood sac with appropriate sufficient pump output would play a vital role in improving this system.…”

Artificial Organs 2008: A Year in Review

“…Hyuk Choi et al. (4) of the Seoul National University, Seoul, Korea compared the hemolytic properties of different shapes of occlusion of the blood sac in an occlusive‐type pulsatile blood pump. The hemolytic performance was affected by the degree of the occlusiveness and was lower than the control roller pump.…”