Comparison of hemodynamic and neuroendocrine changes during total intravenous anesthesia and inhalation anesthesia

Özkan, Sezai; Cingözbay, Bekir Yılmaz; Usyilmaz, Serdar; Çankir, Zeki; Cebeci, Bekir Sıtkı; Gökben, Merih

doi:10.1016/s0011-393x(01)80023-0

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…These findings differ from a previous study, which concluded that haemodynamic and neuroendocrine responses to surgical stress were better controlled with TIVA compared with inhalation anaesthesia. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown a benefit of total intravenous anaesthesia (TIVA) over inhalational anaesthesia in non HIPEC surgeries. [ 6 ] Numerous studies have investigated the influence of anaesthetic techniques on the immune function and their biological effect on malignant tumours. [ 7 ] However, no prospective studies have evaluated the effects of anaesthesia techniques during HIPEC.…”

Section: Introductionmentioning

confidence: 99%

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A pilot randomised clinical trial comparing desflurane anaesthesia vs total intravenous anaesthesia, for changes in haemodynamic, inflammatory and coagulation parameters in patients undergoing hyperthermic intraperitoneal chemotherapy

et al. 2020

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Background and Aims: Cytoreduction and hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) cause numerous pathophysiological changes. The objective of this study was to compare the effect of two anaesthetic techniques on haemodynamic changes, inflammatory and coagulation parameters during this procedure. Methods: Twenty-one consenting adults undergoing CRS+HIPEC procedure, were block randomised to receive desflurane (V, n = 9) or TIVA (T, n = 12). After epidural catheter placement and intravenous induction of anaesthesia in both groups with fentanyl, propofol and rocuronium, anaesthesia was maintained with propofol or with desflurane, based on group allocation. Haemodynamic and temperature changes were assessed intra-operatively and variance was analysed. Inflammatory and coagulation markers were measured and compared at five time-points in the peri-operative period. Categorical variables were analysed using Chi square or Fisher exact test. Continuous variables were compared using t -test or Wilcoxon rank sum test. Results: Changes in core body temperature and haemodynamic variables during the hyperthermic intraperitoneal chemotherapy (HIPEC) phase were comparable between the two groups; except mean variance of mean arterial pressure, which was significantly higher ( P = 0.0056) in group V (receiving desflurane) (58.98 ± 36.74) than TIVA group (27.51 ± 14.22). Inflammatory markers in both groups were comparable at five defined time points in the peri-operative period. On post-hoc analysis, pairwise comparisons with baseline, between levels of inflammatory markers within each group showed increased post-operative inflammation in group V. Mean prothrombin time was comparable. Conclusion: Desflurane group suffered greater mean arterial pressure (MAP) instability during the HIPEC phase. Inflammation in both groups was highest during the first 24 h after surgery. Prolonged inflammation was noted in patients receiving desflurane.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%