Comparison of hematological inflammatory parameters in patients with exfoliative glaucoma and exfoliative syndrome

Abstract

Objective: To evaluate the neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), and systemic immune inflammation index (SII) in exfoliative glaucoma (XFG) patients with the aim of comparing the findings with those of healthy controls and exfoliative syndrome (XFS) patients. Methods:In this retrospective cross-sectional study included 134 participants, 22 XFG patients, 41 XFS patients and 71 healthy individuals were examined. Peripheral venous sample values including neutrophil, lymphocyte and platelet levels were recorded from the hospital database.Results: Among evaluated hematological parameters, although the NLR values of the subjects with XFG were greater than those of the subjects with XFS, when the relationship between the NLR, PLR and SII parameters of the XFG and XFS groups, adjusted for age and gender, was examined by logistic regression analysis, no significant difference was found between the groups. Multiple linear regressions of the association between the NLR, PLR and SII parameters and the ocular parameters of the XFG and XFS groups revealed no significant relationship between the blood parameters and ocular measurements. Neutrophil / lymphocyte ratio was found to be the most acceptable discriminant parameter when comparing XFG group with the XFS and control groups (AUC [area under curve]=0.678, AUC=0.663, respectively). Platelet / lymphocyte ratio was found to be the best discriminant parameter between the XFS and control groups (AUC=0.605). Conclusion:No significant difference was found between XFG and XFS groups in terms of NLR, PLR and SII parameters. Considering the fact that NLR has the best AUC when comparing XFG and XFS groups, it may be the most acceptable discriminant parameter between XFG and XFS.

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

“…We found six studies on KC [ 5 , 11 , 13 , 15 , 23 , 27 ], six studies on pterygium [ 12 , 16 , 17 , 19 , 22 , 35 ], four studies on DED [ 6 , 21 , 24 , 28 ], and four studies on iERM [ 7 , 8 , 10 , 30 ]. Also, the association between NLR and glaucoma was investigated in 12 studies [ 3 , 4 , 9 , 14 , 18 , 20 , 25 , 26 , 29 , 31 , 37 , 38 ], of which four were conducted among East Asian patients [ 20 , 29 , 31 , 38 ] and eight among Caucasian patients [ 3 , 4 , 9 , 14 , 18 , 25 , 26 , 37 ]. Among these ten studies, we found five studies on POAG [ 3 , 4 , 14 , 25 , 29 ], six studies on SOAG [ 3 , 9 , 18 , 26 , 37 , 38 ], two studies on PCAG [ 14 , 20 ], and one study on SCAG [ 31 ].…”

“…The association between NLR and glaucoma was investigated in 12 studies [ 3 , 4 , 9 , 14 , 18 , 20 , 25 , 26 , 29 , 31 , 37 , 38 ] including 1568 glaucoma patients and 1737 healthy controls. NLR levels were significantly higher in glaucoma patients compared with controls (SMD =0.56; 95% CI =0.25-0.87, P < 0.001) ( Figure 7 ).…”

“…In subgroup analysis according to ethnicity, there were four studies including East Asian patients [ 20 , 29 , 31 , 38 ], consisting of 1111 patients and 1234 controls, and eight studies including Caucasian patients [ 3 , 4 , 9 , 14 , 18 , 25 , 26 , 37 ] including 457 patients and 483 controls. The pooled results showed that the NLR levels in Caucasian patients with glaucoma were significantly more than healthy controls (SMD =0.80, 95% CI =022-1.39, P value<0.001).…”

“…In the next step, we categorized studies in four groups according to the type of patients' glaucoma and conducted the second subgroup intending to comparing glaucoma patients and healthy controls in each group. There were five studies on primary open-angle glaucoma [ 3 , 4 , 14 , 25 , 29 ] including 595 patients and 547 controls, six studies on secondary open-angle glaucoma [ 3 , 9 , 18 , 26 , 37 , 38 ] comprising 186 patients and 376 controls, two studies on primary closed angle glaucoma [ 14 , 20 ] with 793 patients and 870 controls, and one study on secondary closed angle glaucoma [ 31 ] with 59 patients and 84 controls. NLR was significantly higher in patients with SOAG (SMD =1.35, 95% CI =0.41-2.28, P = 0.005) and significantly lower in patients with SCAG (SMD = -0.58, 95% CI = -0.9 - -0.24, P = 0.42), compared to healthy controls.…”

“…This disorder is often linked with high intraocular pressure (IOP), which is an established risk factor for disease development and permanent blindness [ 36 ]. In the literature focused on glaucoma, the relative importance of NLR has been subject to debate, because some studies reported significant differences in NLR levels between glaucoma patients and healthy control patients [ 3 , 4 , 9 , 14 , 18 , 20 , 25 , 26 , 29 , 31 , 37 , 38 ].…”