Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study

Ye, Fang; Wang, Zhiyi; Cao, Shuman; Liang, Guangcai; He, Danni; Lv, Zhitang; Wang, Liming; Xu, Pengfei; Zhang, Qi

doi:10.1016/j.synbio.2021.03.003

Cited by 35 publications

(42 citation statements)

References 39 publications

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“…Some potentially harmful microbiota, such as Clostridium (Wang et al, 2019), Sutterellaceae (De Angelis et al, 2013), and Enterobacteriaceae (Ding et al, 2020) were more abundant in children with ASD. Bacteroidetes (Strati et al, 2017), Firmicutes (Liu, Li, Sun, et al, 2019), and Prevotellaceae (Pulikkan et al, 2018) were decreased in the ASD group, while they were present at higher amounts in other studies (Rose et al, 2018; Ye et al, 2021; Zou et al, 2020). Several factors may account for the discrepancies, including methodological differences, the intrinsic heterogeneity of symptoms, ethnicity, lifestyle, countries, and living conditions, all of which could influence the microbiota (Vuong & Hsiao, 2017).…”

Section: Introductionmentioning

confidence: 89%

Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Xie

et al. 2022

Autism Research

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Autism spectrum disorder (ASD) is associated with altered gut microbiota. However, there has been little consensus on the altered bacterial species and studies have had small sample sizes. We aimed to identify the taxonomic composition and evaluate the changes in the fecal microbiota in Chinese children with ASD by using a relatively large sample size. We conducted a case–control study of 101 children with ASD and 103 healthy controls in China. Demographic information and fecal samples were collected, and the V3‐V4 hypervariable regions of the bacterial 16S ribosomal RNA (rRNA) gene were sequenced. The alpha and beta diversities between the two groups were significantly different. After correcting for multiple comparisons, at the phylum level the relative abundances of Actinobacteria and Proteobacteria in the case group were significantly higher than those in the control group. The relative abundance of the Escherichia‐Shigella genus in the case group was significantly higher than that of the control group, and the relative abundance of Blautia and unclassified_f__Lachnospiraceae in the control group were higher than that of the case group. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States analysis showed that children with ASD may have disturbed functional pathways, such as amino acid metabolism, cofactor and vitamin metabolism, and the AMP‐activated protein kinase signaling pathway. This study revealed the characteristics of the intestinal flora of Chinese children with ASD and provided further evidence of gut microbial dysbiosis in ASD. Lay Summary This study characterized the gut microbiota composition of 101 children with ASD and 103 healthy controls in China. The altered gut microbiota may contribute significantly to the risk of ASD, including significant increases in the relative abundances of Actinobacteria, Proteobacteria and Escherichia‐Shigella and significant decrease of Blautia and unclassified_f__Lachnospiraceae. This study provided further evidence of gut microbial dysbiosis in ASD.

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Section: Introductionmentioning

confidence: 89%

Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Xie

et al. 2022

Autism Research

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“…Children with autism spectrum disorder (ASD) show differential gut microbiome composition (Wang et al, 2011;Coury et al, 2012;Chaidez et al, 2014;Kheirouri et al, 2016). The microbiome in ASD shows a decrease in the abundance of Escherichia, Shigella, Veillonella, Akkermansia, Providencia, Dialister, Bifidobacterium, Streptococcus, Ruminococcaceae, Megasphaera, Eubacterium_coprostanol, Citrobacter, Ruminiclostridium, and Ruminiclostridium, while Eisenbergiella, Klebsiella, Faecalibacterium, and Blautia are significantly increased (Lau et al, 2021;Ye et al, 2021). Similarly, another research reveals that patients with ASD exhibit a lower Bacteroidetes/Firmicutes ratio (Kang et al, 2013).…”

Section: Microbiome Role In Autismmentioning

confidence: 99%

Recent Advances in Understanding the Structure and Function of the Human Microbiome

2022

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Trillions of microbes live within our bodies in a deep symbiotic relationship. Microbial populations vary across body sites, driven by differences in the environment, immunological factors, and interactions between microbial species. Major advances in genome sequencing enable a better understanding of microbiome composition. However, most of the microbial taxa and species of the human microbiome are still unknown. Without revealing the identity of these microbes as a first step, we cannot appreciate their role in human health and diseases. A shift in the microbial balance, termed dysbiosis, is linked to a broad range of diseases from simple colitis and indigestion to cancer and dementia. The last decade has witnessed an explosion in microbiome research that led to a better understanding of the microbiome structure and function. This understanding leads to potential opportunities to develop next-generation microbiome-based drugs and diagnostic biomarkers. However, our understanding is limited given the highly personalized nature of the microbiome and its complex and multidirectional interactions with the host. In this review, we discuss: (1) our current knowledge of microbiome structure and factors that shape the microbial composition, (2) recent associations between microbiome dysbiosis and diseases, and (3) opportunities of new microbiome-based therapeutics. We analyze common themes, promises, gaps, and challenges of the microbiome research.

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“…Several researchers suggest that changes in microbial diversity may be associated with autistic symptoms, but the results from thirty-one reviewed studies are not consistent. Lower alpha diversity in ASD patients was described in seven studies [26][27][28][29][30][31][32], while in nine cases, higher alpha diversity was found [33][34][35][36][37][38][39][40][41]. Another nine studies did not reveal any signi cant differences in alpha diversity between ASD patients and healthy controls [42][43][44][45][46][47][48][49][50].…”

Section: Gut Bacteria Pro Les In Children With Autism Spectrum Disordermentioning

confidence: 99%

Gut microbiota profiles in mental disorders and their association with behavior in children and adolescents.

Soltysova

Tomova

Ostatníková

2022

Preprint

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The aim of our work is to summarize the current state of knowledge on gut microbiota changes in children and adolescents with mental illnesses. To our knowledge, this is the first review comparing gut microbiota changes in various mental disorders in children and adolescents.To find the relevant articles, PubMed, Web of Science and Google Scholar databases were searched. Articles in English, presenting original data and comparing the composition of gut microbiota in child psychiatric patients with gut microbiota in healthy children and adolescents were selected. Finally, we identified 42 articles eligible for our purpose. Patients with autism spectrum disorders (ASD) were investigated in majority of them. Smaller number of studies evaluating the gut microbiota in children and adolescents with Attention-deficit hyperactivity disorder (ADHD), Rett syndrome, anorexia nervosa, major depressive disorder and tic disorders were found. Main findings of research are discussed in our review, focusing on association between the gut microbiota and behavioral manifestations. To conclude, gut microbiota in children and adolescent with mental disorders is evidently different from control. Most pronounced changes are seen in children with autism spectrum disorders. These changes might be associated with often present gastrointestinal manifestations but, in general, also play a pathogenetic role in behavioral disorders. Based on research findings we assume, that there is a perspective of use of gut microbiota correction in order to improve clinical symptoms in psychiatry.

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Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study

Cited by 35 publications

References 39 publications

Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Alteration of the fecal microbiota in Chinese children with autism spectrum disorder

Recent Advances in Understanding the Structure and Function of the Human Microbiome

Gut microbiota profiles in mental disorders and their association with behavior in children and adolescents.

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