Comparison of gut microbiota compositions and corresponding genetic and metabolic features between guttate and plaque psoriasis by metagenomic sequencing

Wang, Xiaoxu; Liu, Xin; Xiao, Shiju; Zhang, Zongfeng; Wu, Lingjun; Cheng, Yung‐Chi; Tan, Yong; Zhang, Guangzhong; Jiang, Chunyan

doi:10.1016/j.micpath.2022.105560

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…Our results for psoriasis were consistent with previous findings, suggesting that E. fissicatena is more abundant in patients with this disease 20 . Li et al 21 .…”

Section: Discussionsupporting

confidence: 93%

“…19 Our results for psoriasis were consistent with previous findings, suggesting that E. fissicatena is more abundant in patients with this disease. 20 Li et al 21 observed notable associations of LPS and myeloperoxidase (MPO) with pathogenic bacteria such as E. fissicatena. Suppression of the LPS-induced p65 Nuclear factor-κB (NF-κB) signalling cascade has substantial anti-inflammatory effects.…”

Section: F I G U R E 2 All Results Of Mendelian Randomization (Mr) An...mentioning

confidence: 99%

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Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Gu,

Zhang,

Zhao

et al. 2024

Aust J Dermatology

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BackgroundNumerous inflammatory skin diseases are associated with the gut microbiota. Studies of the association between gut microbiota and inflammatory skin diseases have yielded conflicting results owing to confounding factors, and the causal relationship between them remains undetermined.MethodsTwo‐sample Mendelian randomization (MR) was used to examine the association between gut microbiota and four common inflammatory skin diseases: acne, psoriasis, urticaria and atopic dermatitis. The summary statistics of the gut microbiota from the largest available genome‐wide association study meta‐analysis (n = 13,266) conducted by the MiBioGen consortium along with the summary statistics of the four diseases were obtained from the FinnGen consortium. Causal relationships were assessed using the inverse variance weighted (IVW), weighted median, MR‐Egger and maximum likelihood methods, and several sensitivity analyses were performed to ensure the accuracy of the results. Finally, reverse and multivariable MR analyses were performed to verify the robustness of the results.ResultsWe found causal associations of Bacteroidaceae [odds ratio (OR), 2.25; 95% confidence interval (CI), 1.48–3.42; pivw = 0.0001], Allisonella (OR, 1.42; 95% CI, 1.18–1.70; pivw = 0.0002) and Bacteroides (OR, 2.25; 95% CI, 1.48–3.42; pivw = 0.0001) with acne, the Eubacterium fissicatena group with psoriasis (OR, 1.22; 95% CI, 1.10–1.35; pivw = 0.0002) and Intestinibacter with urticaria (OR, 1.28; 95% CI, 1.13–1.45; pivw = 0.0001). These results were corrected for a false discovery rate. Sensitivity analyses were performed to validate the robustness of the associations and reverse MR confirmed that the results were not influenced by the reverse effect.ConclusionOur study revealed that some gut microbiota are risk factors for inflammatory skin diseases, providing new information on potential therapeutic targets. Additionally, a possible association with the gut–skin axis was confirmed. Further research is required to elucidate the mechanisms underlying these relationships.

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“…Our results for psoriasis were consistent with previous findings, suggesting that E. fissicatena is more abundant in patients with this disease 20 . Li et al 21 .…”

Section: Discussionsupporting

confidence: 93%

Section: F I G U R E 2 All Results Of Mendelian Randomization (Mr) An...mentioning

confidence: 99%

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Gu,

Zhang,

Zhao

et al. 2024

Aust J Dermatology

View full text Add to dashboard Cite

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“…Additionally, pathway analysis elucidates that the glutamate metabolic pathway exhibits a significant interrelation with metabolites prevalent in GP. It can be inferred that l-glutamate acts as a crucial biomarker during the latter phases of the GP inflammatory reaction, influencing the interplay between DC and T cells ( 112 ). As such, glutamine metabolism emerges as a fundamental regulatory conduit for the energizing of γδ T and Th17 cells, putting forward the notion that it might offer a viable therapeutic target for ailments driven by these cells.…”

Section: Regulation Of Amino Acid Metabolism On T Cell In Psoriasismentioning

confidence: 99%

Metabolic influences on T cell in psoriasis: a literature review

Su,

Zhao,

Zhang

et al. 2023

Front. Immunol.

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Psoriasis is a systemic inflammatory disease that frequently coexists with various other conditions, such as essential hypertension, diabetes, metabolic syndrome, and inflammatory bowel disease. The association between these diseases may be attributed to shared inflammatory pathways and abnormal immunomodulatory mechanisms. Furthermore, metabolites also play a regulatory role in the function of different immune cells involved in psoriasis pathogenesis, particularly T lymphocytes. In this review, we have summarized the current research progress on T cell metabolism in psoriasis, encompassing the regulation of metabolites in glucose metabolism, lipid metabolism, amino acid metabolism, and other pathways within T cells affected by psoriasis. We will also explore the interaction and mechanism between psoriatic metabolites and immune cells. Moreover, we further discussed the research progress of metabolomics in psoriasis to gain a deeper understanding of its pathogenesis and identify potential new therapeutic targets through identification of metabolic biomarkers associated with this condition.

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Operation of air conditioners affects the microbial pathogenic potential in bedrooms: A metagenomics and culture-dependent study

Liu,

Shen,

Gan

et al. 2023

Building and Environment

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Comparison of gut microbiota compositions and corresponding genetic and metabolic features between guttate and plaque psoriasis by metagenomic sequencing

Cited by 3 publications

References 42 publications

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization study

Metabolic influences on T cell in psoriasis: a literature review

Operation of air conditioners affects the microbial pathogenic potential in bedrooms: A metagenomics and culture-dependent study

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